36 results about "Dyclonine Hydrochloride" patented technology

The invention provides a preparation method of a compound double-layer sustained release emulsion for treating diseases of oral mucosa made from the following raw materials: borneol, calculus bovis artifactus, tindazole tinidazole, dyclonine hydrochloride, Tween-80, glycerol, saccharin sodium, sodium carboxymethyl cellulose (CMC-Na), polyvinyl alcohol PVA17-18 etc. The compound double-layer sustained release emulsion has heat-cleaning and detoxifying, swelling-dispersing and ache-relieving, bacteria-resisting and inflammation-diminishing, putridity-impelling and tissue regeneration-promoting, ulcer face and lesion place-effectively protecting and curing functions, shortens course of the disease, overcomes deficiencies of single-layer emulsion of Chinese medicine or western medicine, is durable with obvious curative effect. When a double-layer emulsion is compared with a single-layer emulsion, medicine is released from a single layer in the single-layer emulsion and from double layers in the double-layer emulsion, thus medicine locally contacts the lesion places, the medicine flowing outside is decreased and foreign odour of medicine in oral cavity is decreased. The compound double-layer sustained release emulsion is made by combining advantages of Chinese medicine and western medicine which are rationally matched, has low dosage, direct effect, convenient use, quick effect, low side effect, determined and good curative effect.

An oral patch for treating toothaches and oral lesions, including mouth ulcers (canker sores / aphthous ulcers) with water soluble topical anesthetics such as dyclonine hydrochloride. In one embodiment, the patch is made by depositing blobs of wet mixture including anesthetic, muco-adhesive hydrocolloids such as collagen, and bingers onto flat sheets. The blobs on the sheets are then dried with air convection, causing the blobs to shrink in height, forming tapered discs with rounded edges. A coating is sprayed onto one side to prevent release of the anesthetic on that side. The base sheets serve as packaging and a lid sheet may be adhered to the base sheet, such as by heat sealing with a hot platen pressing both sheets against an anvil. The platen or the anvil (or both) has recesses that prevent the discs from being pressed during sealing. The sealed package is then cut to size, such as by die cutting.

The invention discloses a mosquito-repelling, bacterium-inhibiting, and itch-relieving spraying agent, which comprises a mosquito-repelling essential oil composition, an essential oil clathrate, and a bacterium-inhibiting and itch-relieving composition; the ratio of mosquito-repelling essential oil composition to essential oil clathrate is 1:10-1:8, the essential oil clathrate covers the mosquito-repelling essential oil composition, the ratio of mosquito-repelling essential oil composition to bacterium-inhibiting and itch-relieving composition is 3:2-2:1; the mosquito-repelling essential oil composition comprises 0.01 to 10 parts of citronella oil, 0.01 to 10 parts of lavender oil, 0.01 to 10 parts of eucalyptus leaf oil, and 0.01 to 10 parts of menthol; the essential oil clathrate comprises 1 to 60 parts of beta-cyclodextrin; the bacterium-inhibiting and itch-relieving composition comprises 0.01 to 10 parts of thymol, 0.01 to 10 parts of alcohol extract of folium artemisiae argyi, and 0.01 to 10 parts of dyclonine hydrochloride. The essential clathrate covers the mosquito-repelling essential oil composition, thus a lasting mosquito-repelling effect can be achieved, and the bacterium-inhibiting and itch-relieving composition can quickly relieve the itch.

The invention discloses medical lubricant. The medial lubricant comprises the following components in percentage by weight: 0.02%-0.8% of organic silicon antifoaming agent, 0.2%-3% of dyclocaine hydrochloride, 0.1%-25% of glycerol, 0.1%-10% of xanthan gum and the balance of water. The medical lubricant can be used for realizing good lubricity, a good antifoaming effect and good water solubility; and moreover, the medical lubricant has the effects of a quick surface anesthetic effect and the like.

The invention relates to a mosquito-repelling and itching-relieving cream and discloses a mosquito-repelling and itching-relieving cream which is prepared from natural herbaceous plant extracts, antistine hydrochloride and dyclonine hydrochloride and has the effects of repelling mosquitos and relieving itching. The prescription of the mosquito-repelling and itching-relieving cream comprises the following main ingredients: a combination of any medicines, such as 1-25 percent of antistine hydrochloride, 0.2-15 percent of dyclonine hydrochloride and 6-8 percent of menthol, 3-5 percent of eucalyptus oil, as well as 3-5 percent of camphor and 0.2-0.6 percent of clove basil oil, and 60-80 percent of matrix. The matrix consists of the following components: 10 percent of anhydrous lanolin, 60 percent of albolene and 30 percent of cera alba. The mosquito-repelling and itching-relieving cream is an external preparation prepared from the pure natural herbaceous plant extracts, the antistine hydrochloride and the dyclonine hydrochloride, has the functions of repelling mosquitos and relieving items, refreshing spirit and restoring consciousness and protecting the skin from mosquito bite, has no any toxic and side effects to the body and is safe and reliable to use.

The invention belongs to the technical field of pharmaceutic preparation, and particularly relates to a thermo-sensitive type dyclonine hydrochloride gel. The gel is prepared from, by weight, 1%-5% of dyclonine hydrochloride, 1%-10% of thermo-sensitive gel substrate, 5%-10% of viscosity modifier, 0.1%-1% of pH modifier, 0.01%-0.1% of preservative, 0.1%-5% of flavoring agent, 2%-8% of medical defoamer and the balance water. The thermo-sensitive type dyclonine hydrochloride gel is a partial anaesthetic, and is used for laryngeal anesthesia and lubrication during upper gastrointestinal endoscopy; at room temperature, the preparation is in a liquid state, and when temperature rises to animal heat, the preparation can become gel in a cavity or a affected part; under the condition of equivalent dose volume, residence time and cover area ratio are increased drastically; the thermo-sensitive type dyclonine hydrochloride gel has the advantages of being strong in anesthesia, fast in efficacy exertion, good in bubble removing effect, appropriate in mouthfeel and the like, improves the compliance of patients, and is worth clinical application and popularization.

The invention discloses a paste film for treating oral ulcer and a preparation method thereof. The paste film comprises 5-8g of dyclonine hydrochloride, 5-10g of chlortetracycline hydrochloride, 3-5g of metronidazole, 0.1-0.3g of dexamethasone sodium phosphate, 30-60g of sodium alginate, 100-150ml of ethanol, 30-80ml of glycerin and the balance purified water, wherein the total volume of the above ingredients is 1000ml. The invention also provides a preparation method of the paste film. The preparation method comprises the following steps of 1, taking sodium alginate, soaking the sodium alginate in ethanol and grinding the moistened sodium alginate in a mortar, 2, taking dyclonine hydrochloride, dissolving the dyclonine hydrochloride by ethanol, and slowly adding the solution into the ground sodium alginate obtained by the step 1, 3, dissolving metronidazole and dexamethasone sodium phosphate in water, slowly adding the solution into the mixed solution obtained by the steps 1 and 2 and carrying out continuous grinding, 4, taking chlortetracycline hydrochloride, adding glycerinum into the chlortetracycline hydrochloride for moistening, slowly adding the mixture into the mixed solution obtained by the step 3 and carrying out continuous stirring to obtain a uniform mixture, and 5, preparing a film, carrying out drying and carrying out split charging. The paste film can be used for treating oral ulcer or oral inflammation and has effects of diminishing inflammation and relieving pain. The paste film can be pasted to an affected part. The preparation method has simple processes and substantial curative effects.

The invention relates to the field of antirust paint and particularly relates to polymer graphene oxide antirust paint which is prepared from the following raw materials in parts by weight: 10-26 parts of polyvinyl chloride grafted maleic anhydride emulsion, 32-40 parts of acrylic emulsion, 5-8 parts of succinic acid, 5-8 parts of epoxidized soybean oil, 2-4 parts of alkyl polyglycol ether, 2-4 parts of acetyl tri(2-ethyl hexa) citrate, 2-4 parts of isopropyl myristate, 5-8 parts of inositol hexaphosphate, 0.5-1 part of dyclonine hydrochloride, 2-3 parts of medical stone powder of 20-50 meshes, 1-2 parts of sodium fluosilicate and 4-8 parts of polymer graphene oxide. According to the antirust paint provided by the invention, by adding the graphene oxide, the bonding property of each raw material in the antirust paint is greatly improved, and anticorrosive and bactericidal effects are realized; and the added medical stone can enhance the adhesion of the antirust paint. The antirust paint has excellent high-temperature resistance, flame retardance, oil immersion resistance and acid-base corrosion resistance; and with high drying speed and remarkably strong impact resistance, the antirust paint does not fall easily when being impacted by a sharp object.

The invention discloses a novel method for synthesizing dyclonine hydrochloride, which uses phenol as a starting material and produces the dyclonine hydrochloride by etherification, acetylation and condensation reaction. The method has the advantages of readily-available raw materials, mild reaction conditions, convenient operation, high yield, good product quality and low cost.

The invention provides an oral ulcer film. 1000-1500 parts of oral ulcer film comprise, by weight, 3-10 parts of hexadecylpyridinium chloride, 3-10 parts of clotrimazole, 3-10 parts of dyclonine hydrochloride, 3-10 parts of lidocaine, 3-15 parts of chitosan, 0.005-0.015 part of betamethasone sodium phosphate, 15-25 parts of polyvinyl alcohol, 25-50 parts of sodium alginate, 100-150 parts of ethyl alcohol and the balance distilled water. The invention further provides a method for preparing the oral ulcer film. The oral ulcer film and the method have the advantages that the oral ulcer film is high in adhesive ability, medicines can be directly applied to ulcer positions, can directly reach focuses and can quickly act, direct effects can be realized, inflammation can be quickly diminished, pain can be quickly relieved, and the ulcer positions can be quickly healed; the oral ulcer film cannot be easily washed away by saliva and can resist elimination effects of the saliva and swallowing to a certain extent, and accordingly the action time of the medicines in lesion regions can be prolonged; the medicines cannot easily reach positions except for the focuses, and accordingly negative influence on internal environments of oral cavities can be prevented; the oral ulcer film is stable in efficacy and convenient to carry and has unique treatment merits.

The present invention discloses an oral preparation of dyclonine hydrochloride for the endoscope examination in upper gastrointestinal tract, which has the effects of anaesthetization and lubrication, and especially an oral preparation comprising dyclonine hydrochloride that has the advantages of avoiding the foam in the body cavity, preventing vomit, and offering a clear view. The preparation of the present invention comprises, as main ingredients, 0.2%-3% weight percent of dyclonine hydrochloride, 1%-12% weight percent of polyvinyl alcohol, 1%-10% volume percent of glycerin, 1%-10% volume percent of a defoaming agent, and a balance of a pharmaceutically acceptable adjuvant. The viscosity of the preparation is in a range of 30 to 300 mpa·s and the pH value is in a range of 2.0 to 8.0.

The invention discloses a medicament for external use for aphtha, which is prepared by mixing 15 to 20g of asparagus juice and 0.25 to 0.5g of dyclonine hydrochloride and then naturally drying the mixture. 0.5g of vitamin E and 4 to 6g of glycerol are added to dispel the specific bitterness of aloe. Medicaments adopted by the invention are all medicaments for oral administration without side effect; and the medicament fully utilizes the functions of sterilization, ulcer resistance and cytothesis of the aloe and the dyclonine hydrochloride, and has the characteristics of remarkable analgesic effect and short healing time.

The invention discloses a mosquito repellent and antipruritic sunscreen cream formula, which comprises the following raw materials in parts by weight: 2-ethylhexyl palmitate 40-44 parts, polydimethylsiloxane 12-16 parts, reactive berry polyphenol 20-24 parts, hydroxyphenyl propyl ester 12-16 parts, hyaluronic acid 14-18 parts, daclonine hydrochloride 16-20 parts, camphor 5-9 parts, peppermint oil12-16 parts, leaves of eucalyptus citriodora 8-12 parts, callicarpa nudiflora 12-16 parts, thymol 13-17 parts, wormwood oil 4-8 parts; wild chrysanthemum 14-18 parts, cnidium monnieri 9-13 parts and an appropriate amount of water. Based on the original 2-ethylhexyl palmitate, polydimethylsiloxane, reactive berry polyphenol, hydroxyphenyl propyl ester, hyaluronic acid and water, the dacronine hydrochloride, camphor, peppermint oil, leaves of eucalyptus citriodora, callicarpa nudiflora, thymol, wormwood oil, wild chrysanthemum and cnidium monnieri are added, which can prevent mosquito bites andrelieve itching, so that sunscreen has mosquito repellent and antipruritic effects.

The invention provides a preparation method of a compound double-layer sustained release emulsion for treating diseases of oral mucosa made from the following raw materials: borneol, calculus bovis artifactus, tindazole tinidazole, dyclonine hydrochloride, Tween-80, glycerol, saccharin sodium, sodium carboxymethyl cellulose (CMC-Na), polyvinyl alcohol PVA17-18 etc. The compound double-layer sustained release emulsion has heat-cleaning and detoxifying, swelling-dispersing and ache-relieving, bacteria-resisting and inflammation-diminishing, putridity-impelling and tissue regeneration-promoting,ulcer face and lesion place-effectively protecting and curing functions, shortens course of the disease, overcomes deficiencies of single-layer emulsion of Chinese medicine or western medicine, is durable with obvious curative effect. When a double-layer emulsion is compared with a single-layer emulsion, medicine is released from a single layer in the single-layer emulsion and from double layers in the double-layer emulsion, thus medicine locally contacts the lesion places, the medicine flowing outside is decreased and foreign odor of medicine in oral cavity is decreased. The compound double-layer sustained release emulsion is made by combining advantages of Chinese medicine and western medicine which are rationally matched, has low dosage, direct effect, convenient use, quick effect, low side effect, determined and good curative effect.

The invention relates to a medicine for treating white lesions of vulva and a preparation method thereof. The medicine for treating white lesions of vulva is prepared from cortex dictamni, nystatin, dyclonine hydrochloride, dexamethasone, borneol, phenergan, chloromycetin powder and hydrophilic cream base II by virtue of special preparation steps. The medicine for treating white lesions of vulva is capable of treating both symptoms and root causes and small in toxic and side effects, provides a novel thought and novel method for treating the white lesions of vulva, and has wide clinical application value.

The invention discloses a dyclonine hydrochloride synthesizing method and belongs to the field of chemical synthesis. The dyclonine hydrochloride synthesizing method reacting p-hydroxyacetophenone with n-butyl bromide in an alkali system and under the condition of phase transfer catalysts to synthesize p-butoxyacetophenone; performing Mannich reaction on the p-butoxyacetophenone, paraformaldehyde and piperidine hydrochloride under acidic conditions to synthesize crude dyclonine hydrochloride, and performing a refining process to obtain pure dyclonine hydrochloride. The purity of the refined pure dyclonine hydrochloride can reach up to 99.7%. The dyclonine hydrochloride synthesizing method is simple in operation and applicable to industrial production.

The invention discloses a drug composition, and a preparation method and application thereof, and relates to the field of veterinary drugs. The drug composition comprises a solvent, wherein the solvent is prepared from the following components: 0.02 to 0.2 g / L of dyclonine hydrochloride, 0.05 to 0.2 g / L of terbinafine hydrochloride, and 0.01 to 0.1 g / L of matrine, and the solvent is an aqueous solution of glycerol. When used for treating auditory meatus inflammation of dogs and cats, the drug composition has the advantages of high efficacy, short treatment period and small damage. Furthermore,the invention relates to the preparation method of the drug composition and application of the drug composition in preparation of a drug for treating the auditory meatus inflammation of the dogs andcats.

The invention provides a soak solution for esparto grasses and a preparation method of the soak solution. The soak solution is prepared from the following raw materials in parts by weight: 0.5-1 part of triclosan, 1-2 parts of chitosan, 2-3 parts of dyclonine hydrochloride, 4-6 parts of xanthan gum, 0.8-1.5 parts of beta-sitosterol fatty acid ester, 2-3 parts of gamma-aminobutyric acid, 1-2 parts of linalool, 0.2-0.25 part of 2,7-dyhydroxyl-4-masmafin-2-O-glucoside, 0.4-0.8 part of physcion, 5-10 parts of a plant extracting solution, and 200-240 parts of deionized water. By the soak solution, the toughness of the esparto grasses can be improved, residual bacteria and worm eggs in the esparto grasses can be killed fully, but faint scent and color of the grasses are not damaged, the strength of the grasses is greatly improved, and therefore, the service life of a broom manufactured by the esparto grasses can be prolonged by 1-2 years.

The invention discloses a process for synthesizing dyclonine hydrochloride. The process comprises the following steps: by taking phenol as a start raw material, firstly, synthesizing phenate butyl with n-butyl bromide; secondly, under the catalysis action of chloride, reacting the phenate butyl with 3-chloropropionyl chloride so as to obtain 3-chlorine-4'-butoxy propiophenone; and further reacting 3-chlorine-4'-butoxy propiophenone with piperidine hydrochloride under the action of triethylamine, thereby obtaining the dyclonine hydrochloride. As an organic solvent is adopted as a solvent, the process is short in reaction time, low in temperature, small in impurity and high in yield, meanwhile the process is simple, no distillation is needed, high-purity phenate butyl is prepared directly, no toxic acetic anhydride is used, and industrial large-scale production is facilitated.

The invention relates to a new application and a use method of dyclonine hydrochloride mucilage, in particular to a new application of dyclonine hydrochloride mucilage in full urethra ultrasonic examination. According to the novel application and the using method of the dyclonine hydrochloride mucilage, the dyclonine hydrochloride mucilage filled urethra ultrasonic examination can provide urethrostenosis information in detail and make correct estimation on the scar tissue range, and the dyclonine hydrochloride mucilage is high in viscosity, can be used for surface anesthesia, improves the examination comfort of a patient, and has a good application prospect. The clinical value is positive. Along with the development of an ultrasonic technology, the hardness of urethral mucosa can be evaluated by utilizing elastic ultrasound, so that the real situation of urethral stricture can be more accurately judged.

The application discloses a method for detecting the content of dyclonine hydrochloride mucilage or related substances through a high performance liquid chromatography. According to the method, when the content of the dyclonine hydrochloride mucilage is detected, a linear correlation coefficient R2 between the concentration and a peak area in a concentration range equivalent to 10-200% of the concentration of a test sample is greater than 0.9990, the repeatability is good, the quantification limit of the dyclonine hydrochloride is 0.0510 microgram / ml, the average recovery rate is 98-101%, andthe RSD is less than 2.0%. During detection of related impurities, the separation degree between the impurity I and the dyclonine hydrochloride peak is 29.6, the quantitative limit concentration of the impurity I is 1.734 microgram / ml; the linear equation of the impurity I is as follows: A=2*10<7> C-220161, the correlation coefficient is 0.9993, the peak area RSD of the impurity I is 0.6%, the average recovery rate is 97.9%, the RSD is 3.5%, and the detection limit is 0.0041 microgram / ml.

An exterior-applied medicine for treating recurrent aphtha is prepared from aloe juice, dyclocaine hydrochloride, hydroxypropyl cellulose powder, VE and glycerine through proportional mixing, spreading on glass, slicing and natural drying. Its advantages are high antalgic effect and quick healing.

The invention relates to the field of pastes, aims to solve the problem of high requirements on adhesion and air permeability of an adhesive layer when the adhesive layer of a plaster is coated on ointment, and provides a plaster for treating arthralgia. The plaster comprises a stripping layer, an ointment layer and a backing layer which are sequentially adsorbed, the inner side of the backing layer is divided into a middle part and a periphery; wherein the ointment layer is attached to the middle part, a circle of adhesive ring is arranged on the periphery of the backing layer, the adhesive ring has viscosity and can be attached to the skin, the stripping layer is attached to the adhesive ring and opposite to the backing layer to clamp the adhesive ring and the ointment layer between theadhesive ring and the ointment layer to play a role in protection, and during use, the stripping layer is stripped off, and the ointment layer comprises indometacin, dyclonine hydrochloride and menthol. The adhesive layer is arranged on the periphery of the ointment layer by a circle, the adhesive ring and the ointment layer do not interfere with each other, and the adhesion between the adhesive ring and the ointment layer does not need to be considered; the ointment layer is in direct contact with the skin without passing through the adhesive ring, so that the human body can better absorb theointment layer, and the permeability of effective components of the ointment in the adhesive ring does not need to be considered.

The invention discloses medical lubricant. The medial lubricant comprises the following components in percentage by weight: 0.02%-0.8% of organic silicon antifoaming agent, 0.2%-3% of dyclocaine hydrochloride, 0.1%-25% of glycerol, 0.1%-10% of xanthan gum and the balance of water. The medical lubricant can be used for realizing good lubricity, a good antifoaming effect and good water solubility; and moreover, the medical lubricant has the effects of a quick surface anesthetic effect and the like.

The invention relates to a medicament prepared by Chinese drugs and western medicines and used for treating acne by beautifying gel. The raw materials contain clindamycin hydrochloride, ciprofloxacin,dyclonine hydrochloride, 95 percent ethanol, fresh aloe, glycerin, carboxymethyl cellulose and water for injection. The medicament of the invention fully develops the effective ingredients of the Chinese and the western medicines, all the ingredients are mutually increased in efficacies and complemented. The invention is used for treating acne, with obvious effect and evident curative effect.

The invention discloses a brand new synthesis method of dyclonine hydrochloride. According to the method, p-bromoacetophenone is taken as a starting material, and dyclonine hydrochloride is produced through Mannich reaction and C-O cross-linking reaction. Compared with the prior art, the method has the advantages of easily available starting materials, controllable reaction temperature, higher purity, shortened time, increased yield and the like, avoids the use of high-toxicity reagents such as acetyl chloride, 3-chloropropionyl chloride and the like, and is more beneficial to drug safety and industrial mass production.

The invention discloses a mosquito-repelling, bacterium-inhibiting, and itch-relieving spraying agent, which comprises a mosquito-repelling essential oil composition, an essential oil clathrate, and a bacterium-inhibiting and itch-relieving composition; the ratio of mosquito-repelling essential oil composition to essential oil clathrate is 1:10-1:8, the essential oil clathrate covers the mosquito-repelling essential oil composition, the ratio of mosquito-repelling essential oil composition to bacterium-inhibiting and itch-relieving composition is 3:2-2:1; the mosquito-repelling essential oil composition comprises 0.01 to 10 parts of citronella oil, 0.01 to 10 parts of lavender oil, 0.01 to 10 parts of eucalyptus leaf oil, and 0.01 to 10 parts of menthol; the essential oil clathrate comprises 1 to 60 parts of beta-cyclodextrin; the bacterium-inhibiting and itch-relieving composition comprises 0.01 to 10 parts of thymol, 0.01 to 10 parts of alcohol extract of folium artemisiae argyi, and 0.01 to 10 parts of dyclonine hydrochloride. The essential clathrate covers the mosquito-repelling essential oil composition, thus a lasting mosquito-repelling effect can be achieved, and the bacterium-inhibiting and itch-relieving composition can quickly relieve the itch.

The invention relates to the field of medical supplies and in particular relates to a compound indometacin and dyclonine paste with a waterproof performance and a preparation method of the compound indometacin and dyclonine paste. The compound indometacin and dyclonine paste sequentially includes a waterproof layer, a base cloth layer and a plaster layer, wherein the waterproof layer includes a first waterproof layer and a second waterproof layer, two sides of the base cloth layer are distributed with the first waterproof layer and the second waterproof layer, the second waterproof layer is located between the base cloth layer and the plaster layer, the waterproof layer is a superhydrophobic surface layer, the plaster layer is a traditional Chinese medicine coating layer, and the base cloth layer is a non-woven fabric. Calculated by 100%, the paste includes the components in parts by mass: 2-3 parts of indometacin, 0.1-0.3 part of dyclonine hydrochloride, 7-9 parts of camphor, 3-5 parts of menthol, 29-31 parts of zinc oxide, 22-24 parts of rosin, 3-5 parts of wool fat, 3-5 parts of dimethyl sulfoxide and the balance of rubber. The compound indometacin and dyclonine paste is relatively strong in surface hydrophobicity, not easily attached by dirty marks and relatively strong in air pollution prevention capability.