Method for preparing compound double-layer sustained-release medicinal membrane for treating oral mucosal disease

Abstract

The invention provides a preparation method of a compound double-layer sustained release emulsion for treating diseases of oral mucosa made from the following raw materials: borneol, calculus bovis artifactus, tindazole tinidazole, dyclonine hydrochloride, Tween-80, glycerol, saccharin sodium, sodium carboxymethyl cellulose (CMC-Na), polyvinyl alcohol PVA17-18 etc. The compound double-layer sustained release emulsion has heat-cleaning and detoxifying, swelling-dispersing and ache-relieving, bacteria-resisting and inflammation-diminishing, putridity-impelling and tissue regeneration-promoting, ulcer face and lesion place-effectively protecting and curing functions, shortens course of the disease, overcomes deficiencies of single-layer emulsion of Chinese medicine or western medicine, is durable with obvious curative effect. When a double-layer emulsion is compared with a single-layer emulsion, medicine is released from a single layer in the single-layer emulsion and from double layers in the double-layer emulsion, thus medicine locally contacts the lesion places, the medicine flowing outside is decreased and foreign odour of medicine in oral cavity is decreased. The compound double-layer sustained release emulsion is made by combining advantages of Chinese medicine and western medicine which are rationally matched, has low dosage, direct effect, convenient use, quick effect, low side effect, determined and good curative effect.

Description

technical field [0001] The invention provides a preparation method of a sustained-release medicinal film, in particular a preparation method of a compound double-layer sustained-release medicinal film for treating oral mucosal diseases. Background technique [0002] Oral mucosal ulcer diseases are clinical frequently-occurring diseases, especially recurrent aphthous ulcer is the most common oral mucosal disease, and the prevalence rate is as high as about 20%. The disease recurs periodically, with obvious burning pain, which affects the patient's language, diet, and mood, and the burden of thought is heavy. Some patients have "cancer fear", which seriously affects the work, study and daily life of the patient. The etiology of the disease is complex, and there are obvious individual differences. There are many research reports on its pathogenic factors, but there is no unified conclusion yet. Since the etiology of recurrent aphthous ulcer is still unclear, although there ar...

AI Technical Summary

Problems solved by technology

[0008] There are certain differences in the prescriptions of various Chinese and Western medicines and compound medicine films used for the treatment of oral ulcers. They all have good curative effects for the treatment of various oral ulcers. For recurrent oral ulcers, the intermission period can be prolonged and the recurrence can be reduced, but they cannot be treated. The curative effect is still unsatisfactory