57 results about "Drug excipient" patented technology

The invention provides the application of betulinic acid and salts thereof suitable for medical purpose in the preparation of a drug of a glycosidase inhibitor. The compound of the invention is the compound of lupeol type pentacyclic triterpene acid obtained by separating lagerstroemia plants. Pharmacological tests prove that the compound has obvious effect in inhibiting Alpha-glucosidase, the inhibitory activity of which exceeds acarbose 100% for initial therapy. Therefore, drug compositions made from the compound or the salts thereof suitable for medical purpose and drug excipients or carriers allowable for preparation can be applied to the preparation of drugs for preventing or treating Type II Diabetes, namely, noninsulin-dependent diabetes mellitus. The constitutional formula shown in formula (1) of the invention is shown as above.

The invention discloses an anti-cancer drug prepared by using a 3D printing technology, and a method. The method comprises: uniformly mixing an anti-cancer drug, a high polymer material, and a drug excipient, extruding obtained mixture through an extruding machine, to obtain a wire rod containing drug; using computer design software to design a structure model of the anti-cancer drug, storing the structure model in a file format which can be identified by a 3D printer, importing the file into the 3D printer, using hierarchical software to perform hierarchical processing; respectively importing the high polymer material and the obtained wire rod containing drug into the 3D printer, selecting the drug structure model, setting printing precision, velocity, and temperature, to obtain the 3D printed anti-cancer drug. The method is characterized in that the method is convenient and fast and is simple in operation, and the size and shape of a tablet can be designed according to variation of weather and climate. The method can make tablets in different sizes and shapes, and utilization rate of the drug can be effectively improved.

The invention relates to an antiviral influenza drug and a preparation method of the antiviral influenza drug. The drug comprises the following ingredient by weight: 8-12 parts of ephedra, 8-12 parts of cassia twig, 5-7 parts of processed licorice root, 8-12 parts of semen armeniacae amarae, 8-12 parts of ginger, 18-22 parts of Chinese-date and 18-22 parts of gypsum. The preparation method comprises the steps of soaking the cassia twig and the ginger, extracting to obtain volatile oil and liquid medicine for standby application; then mixing the drug dregs and other crude drugs, extracting to obtain liquid medicine, mixing the liquid medicines obtained from the above two steps, then concentrating, spraying and drying to obtain a drug extract; and finally, mixing the extract with a pharmaceutically acceptable carrier or a drug excipient according to proportion, pelletizing and drying, and adding the standby volatile oil to prepare the antiviral influenza drug. The antiviral influenza drug has obvious curative effect, can be used in large range, and is convenient to take, accurate in curative effect, controllable in quality, simple in manufacturing process flow, controllable in quality standard, energy-saving in energy resources, free from environment pollution, small in potential safety hazard, and suitable for industrial production.

The invention provides application of nestorone (16-methylene-17alpha-acetyloxy-19-norpregn-4-ene-3, 20-dione, nes) to preparation of neuroprotective drugs for improving and treating Parkinson's disease. The prepared drugs contain preparation-allowable drug excipients or carriers. The drugs can be made into the forms of liquid, particle, controlled release formulation, electuary, tablet or capsule. In terms of cells, the neuroprotective drugs and application thereof using nestorone to improve and treat Parkinson's disease are demonstrated, and the curative effect of the neuroprotective drugs compared with progesterone on improving and treating Parkinson's disease is better, and the toxic and side effects to nervous systems are low.

The invention relates to a new veterinary medicine preparation (sulfamonomethoxine suspension injection or sulfamonomethoxine sodium suspension injection) and a preparation method thereof; the new veterinary medicine preparation is prepared by taking sulfamonomethoxine or sulfamonomethoxine sodium as main drug and other excipients for assist. The percentage of the main ingredients in the suspension is as follows: 1%-50% (W / V) of sulfamonomethoxine or sulfamonomethoxine sodium and the rest of drug excipients; the excipients include a suspending agent and a disperse medium. The invention takes oil solvent as the disperse medium to prepare sulfamonomethoxine or sulfamonomethoxine sodium into a long-acting and sustained-release preparation; by adopting intramuscular injection for drug administration, the in vivo acting time of the drug can be significantly prolonged, the times of drug administration are reduced and the blood concentration of diseased livestock can keep stable. The new veterinary medicine preparation of the invention is safe, stable, effective and controllable in quality, thus being widely applicable to the treatment of bacterial infection and parasitic infestation in livestock.

The invention discloses an external medicine for treating autoimmune dermatosis and a preparation method and application thereof. The main ingredient of the external medicine is a NK cell stock solution, wherein the NK cell stock solution is obtained by performing multiplication culture on NK cells, the NK cell stock solution is mixed with different drug excipients, and an external liquid preparation or an external paste preparation can be prepared. Compared with the prior art, the external medicine contains anti-inflammatory and high-efficiency active factors, the active ingredients of the medicine can safely and effectively reach the lesions so as to eliminate the pathogenesis, and the effects of rapidly relieving pain and relieving symptoms can be achieved. After the medicine is used, a skin protection film can be formed, and injury repair is facilitated. The medicine has excellent effects on autoimmune dermatosis such as psoriasis, pityriasis rosea, erythema multiforme and the like, is convenient to use, does not have any toxic or side effect due to long-term use, and is also applicable to special crowds who are unsuitable to use other types of medicines and hormones, particularly people with skin allergy, infants, pregnant women and the like.

The invention relates to a composition having effects of whitening, removing spots and refreshing skin. The composition is obtained by uniformly mixing powder of ginkgetin extracted from ginkgo leaves, powder of sesamin extracted from sesame seed meal and powder of astragalosides extracted from radix astragali according to a mass ratio of (1-10): (1-10): (1-10). The composition and make-up preparations or drug excipients can be mixed into an external skin preparation such as cream, an emulsion, gel, paste and a subcutaneous injection. A pharmacological test research shows that the composition has effects of inhibiting skin tyrosinase activity and melanin generation. A clinical trial shows that the composition has obvious whitening, spot-removal and skin-refreshing effects on people having a medium yellow facial color and facial color spots, has an effective rate of 100%, is safe and has no side-effect.

The invention discloses a method for preparing nano cellulose by simultaneous assistance of ultrasonic waves and microwaves, belonging to the field of biomass nano materials. According to the nano material, liquid acid is taken as a catalyst, and the high-efficiency hydrolysis at the amorphous area of cellulose is promoted due to the simultaneous assistance of the ultrasonic waves and microwaves, so that the nano cellulose is rapidly prepared by plant fiber raw materials. The preparation method comprises the steps of acid hydrolysis of plant cellulose, centrifugal recovery of liquid acid and centrifugal separation of nano cellulose. According to the method, the mechanical dispersion action and ultrasonic cavitation effect of the ultrasonic waves, microwave uniform heating effect, catalytic action of the liquid acid and the synergistic effect of the ultrasonic waves and microwaves are utilized sufficiently, and the hydrolytic process of cellulose is enhanced, so that the high-efficiency and rapid preparation of the nano cellulose can be realized. The prepared nano cellulose material can be used for food additives, drug excipients, engineering material additives, specialty paper additives and the like.