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Chinese medicinal composition preparation and preparation method thereof and quality control method

A quality control method and composition technology, applied in the direction of drug combination, pharmaceutical formula, non-central analgesic, etc.

Active Publication Date: 2010-06-23
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the prior art is effectively controlling the process and quality of the composition, there are still many defects, which need to be further improved.

Method used

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  • Chinese medicinal composition preparation and preparation method thereof and quality control method
  • Chinese medicinal composition preparation and preparation method thereof and quality control method
  • Chinese medicinal composition preparation and preparation method thereof and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0317] Embodiment 1 sugar-free granule

[0318] Honeysuckle extract 30g, Scutellaria baicalensis extract 12g, dextrin 126.8g, stevia 1.18g

[0319] Take honeysuckle, add water to decoct twice, add 8 times of water for the first time and decoct for 2 hours, add 6 times of water for the second time and decoct for 2 hours, combine the decoction, filter, add lime milk to the filtrate to adjust the pH value to 10~ 12. Stand still, filter out the precipitate, add appropriate amount of water, adjust the pH value to 6-7 with sulfuric acid, stir well, filter, and concentrate the filtrate to a thick paste to obtain the honeysuckle extract; take Scutellaria baicalensis, add it to boiling water and decoct 2 times, 1 hour each time, combine the decoction liquid, filter, add sulfuric acid to the filtrate to adjust the pH value to 2, let it stand, filter and collect the precipitate, wash with ethanol in an appropriate amount, and dry to obtain the Scutellaria baicalensis extract; the honeysu...

Embodiment 2

[0320] Embodiment 2 powder

[0321] Honeysuckle extract 20g, Scutellaria baicalensis extract 25g, dextrin 65g, stevia 1.8g

[0322] Take honeysuckle, add water to decoct 3 times, add 6 times of water for the first time and decoct for 3 hours, add 4 times of water for the second time and decoct for 3 hours, combine the decoction, filter, add lime milk to the filtrate to adjust the pH value to 11, Stand still, filter the precipitate, add appropriate amount of water, adjust the pH value to 6.5 with sulfuric acid, stir well, filter, and concentrate the filtrate to a thick paste to obtain the honeysuckle extract; take Scutellaria baicalensis, add it to boiling water and decoct once, After 1.5 hours, combine the decoction liquid, filter, add sulfuric acid to the filtrate to adjust the pH value to 1, let it stand, filter and collect the precipitate, wash with an appropriate amount of ethanol, and dry to obtain the Scutellaria baicalensis extract; , dextrin, and stevia are mixed in p...

Embodiment 3

[0323] Embodiment 3 capsules

[0324] Honeysuckle extract 30g, Scutellaria baicalensis extract 12g, dextrin 126.8g, stevia 1.18g

[0325] Add conventional excipients, and make clinically or pharmaceutically acceptable capsules according to conventional processes.

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Abstract

The invention discloses a Chinese medicinal composition preparation and a preparation method and a quality control method thereof, particularly discloses a Chinese medicinal composition preparation with effects of clearing away heat and toxic material and diminishing inflammation and a preparation method and a quality control method thereof. The Chinese medicinal composition preparation comprises the following raw materials by weight portion: 10 to 50 portions of extract of honeysuckle flower; 5 to 30 portions of extract of baical skullcap root; 60 to 180 portions of dextrin; and 0.5 to 2.0 portions of steviosin. The Chinese medicinal composition sugar-free granules replace the conventional sucrose and starch in the conventional process with dextrin and steviosin so as to not only have the characteristics of the common granules, but also have the advantages of good stability of the medicament, dosage reduction of the drug excipient, image improvement of the Chinese medicinal preparation, curative effect strengthening and the like. The invention also discloses a method for measuring the content of chlorogenic acid and the content of baicalin and testing microbial limit. The experiments prove that the testing specificity is good, the stability is high, the repeatability is good, and the precision is high.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition preparation, a preparation method and a quality control method, in particular to a heat-clearing, detoxifying and anti-inflammatory Chinese medicine composition preparation, a preparation method and a quality control method. Background technique [0002] Inflammation refers to a basic pathological process that occurs in living tissues with vascular system to the stimulation of various damage factors, mainly in defense response. The local vascular response is a major feature of the inflammatory process and a central link in the defense response. The local manifestations of inflammation are redness, swelling, heat, pain and dysfunction, and also accompanied by systemic reactions such as fever and changes in peripheral white blood cell count. [0003] Honeysuckle and Scutellaria baicalensis, as traditional Chinese medicines for clearing away heat, detoxification and anti-inflammation, ar...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K47/40A61K9/16G01N30/02A61P29/00
CPCY02A50/30
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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