38results about How to "Convenient clinical administration" patented technology

The present invention relates to a fuliconazole injection. Said injection includes the following components; (by wt%) fuliconazole 0.01-20%, cyclodextrin or cyclodextrin derivative 0%-60%, water-soluble excipient 0-75%, solubilizer 0%-20% and the rest is injection water. Its preparation method includes the following steps: mixing the above-mentioned raw materials, using active carbon to remove impurity and heat source, filtering, fine filtering, filling, sterilizing, checking and putting in storage.

The invention provides enrofloxacin nano emulsion and a method for preparing the same and relates to a veterinary medicine preparation. The invention aims to provide the enrofloxacin nano emulsion which has the advantages of good solubility and palatability, strong medicinal effect and long medicament acting time and a method for preparing the same. The enrofloxacin nano emulsion is prepared from the following raw materials in part by weight: 0.1 to 16.0 parts of enrofloxacin medicinal materials, 28.0 to 32.0 parts of surface active agent, 0.2 to 21.5 parts of auxiliary surface active agent, 1.6 to 5.0 parts of oil, and 33.0 to 54.0 parts of distilled water. The enrofloxacin nano emulsion has the advantages of simple preparation method, low production cost and easy mass industrialized production.

The invention discloses a nimodipine micelle injection and a preparation method thereof. The nimodipine micelle injection is prepared by using active ingredients, i.e. nimodipine and phospholipid / bile salt. According to the nimodipine micelle injection disclosed by the invention, the solubility of the nimodipine is greatly increased, and no crystal precipitation exists when the nimodipine micelle injection is diluted; the biocompatibility of the phospholipid / bile salt is good, and organic solvents with great toxic side effects, such as ethyl alcohol, propylene glycol and the like, are not needed to for solubilizing so that the toxicity of the nimodipine micelle injection is lowered, the vascular stimulation is little, and the adverse reaction of the nimodipine micelle injection is reduced; and the nimodipine micelle injection can be directly used for intravenous injection and can also be used for instilling after the nimodipine micelle injection is diluted to various degrees, and thus, the clinical administration is greatly facilitated.

An injection of itraconzole is prepared from itraconazole, the medical auxiliary composed of cyclodextrin or its derivative, and water-soluble excipient, and water.

The invention discloses application of curcumin to preparation of drugs for treating cerebral ischemia / reperfusion injuries, belonging to the technical field of drug preparation. A cerebral ischemia / reperfusion injury model is prepared and curcumin-PVP (polyvinylpyrrolidone) solid dispersions are used for treating the disease model after being dissolved with the saline for injection. Results show that curcumin can obviously improve the injuries of vital organs such as distant livers and kidneys caused by cerebral tissue injuries and cerebral ischemia / reperfusion injuries and can control the expression levels of several factors related to apoptosis, inflammations and oxidation, control further aggravation of the injuries and protect the vital organs such as cerebral tissues and livers and kidneys.

The invention relates to ibuprofen injection and a preparation method thereof. The ibuprofen injection comprises 0.5 to 20 weight percent of ibuprofen, 10 to 60 weight percent of cyclodextrin or cyclodextrin derivatives, 1 to 40 weight percent of water soluble excipient and the balance of water, wherein ibuprofen serves as a main medicament; and the cyclodextrin or cyclodextrin derivatives and the water soluble excipient serve as medicinal auxiliary materials. In the invention, the cyclodextrin or cyclodextrin derivatives represented by hydroxypropyl-beta-cyclodextrin is used to make the ibuprofen, which used to be water insoluble, very water soluble. The stability of the medicament is improved. The clathrate compounds can be made into injection using water as a solvent or power for injection. Thus, it is very convenient to administrate the medicament in clinic and it is easy to control injection volume. Meanwhile, the drawback of the universal adoption of auxiliary materials and solvents for injection, which are very dangerous, such as organic solvents and cosolvents, of the conventional insoluble and soluble medicinal injection is overcome.

The invention discloses enrofloxacin sustained-release tablets for pets and a preparation process for the same. The enrofloxacin sustained-release tablets disclosed by the invention are stable in medicine release and safe in medication, as well as is composed of enrofloxacin, a sustained-release or controlled-release material, a filler, an adhesive, a lubricant and a flavouring agent. The enrofloxacin sustained-release tablets prepared by the preparation process disclosed by the invention have the characteristics of being convenient to administrate, lasting in action and stable in curative effect.

The invention belongs to the field of Chinese medicinal preparations for livestock, and specifically relates to a Chinese medicinal compound preparation for protecting liver and removing mildew and a preparation method of the Chinese medicinal compound preparation. The Chinese medicinal compound preparation comprises 10-20 parts of pseudo-ginseng, 10-20 parts of schisandra, 10-15 parts of silybum marianum, 10-20 parts of licorice, 10-15 parts of red-rooted salvia root, 20-30 parts of yeast cell wall, 5-10 parts of vitamin C and 2-5 parts of glucuronolactone. The Chinese medicinal compound preparation can be used for cleaning toxin inside the livestock while removing mildew, and can also improve the immunity of the body so as to strengthen the disease resistance; and all components are safe and non-residual, so the effect is significant.

The invention belongs to the field of feed additives, and mainly relates to a feed additive for improving intestinal environment, and a preparation method thereof. 100 Parts of the feed additive comprise, by weight, 30-50 parts of xylooligosaccharide, 10-20 parts of garlicin, 5-10 parts of lactic acid powder, 5-10 parts of enzyme production probiotics, 10-15 parts of vitamin C, and the balance of anhydrous sugar. All components mutually cooperate with each other and complement each other to promote propagation of beneficial microbes, such as bifidobacteria and lactic acid bacillus and restrict breeding of Escherichia coli and other harmful bacteria in order to make intestinal dysbacteriosis recover balance or be converted to a body benefiting balance state.

The invention discloses ciprofloxacin thermo-sensitive type in-situ gel composition and belongs to the field of veterinary drug preparations. The thermo-sensitive type in-situ gel composition comprises, by weight volume (g / ml), 5%-10% of ciprofloxacin, 20%-26% of poloxamer 407, 0.5%-10% of poloxamer 188, 0.01%-0.04% of edetic acid, 0.009%-0.03% of bacteriostatic agent, and 0.1%-0.2% of antioxidant. Solvent of the composition is acetic acid - sodium acetate buffer solution. The invention further discloses a preparing method of the composition. The ciprofloxacin thermo-sensitive type in-situ gel composition is liquid at room temperature, jelling temperature is close to body temperature, and therefore dosing is convenient and jelling speed is high, jelling strength and adhering function are good, the dosing can be achieved with accurate positioning, and loss of drug is reduced. Furthermore, the ciprofloxacin thermo-sensitive type in-situ gel composition and the preparing method thereof have controlled-releasing and long-acting functions, dosage is low, the number of times of dosing is small, harm caused by implants normally used is avoided, and pain of patients is relieved.

The invention discloses a lipoic acid mixed micelle which is prepared from lipoic acid, phospholipid and sodium lipoate, the components are simple, the drug loading capacity is high, and the obtained mixed micelle has relatively strong stability and can still keep the properties of the micelle after different dilution ratios and long-term storage. The invention further discloses a preparation method of the mixed micelle, and the preparation method is simple in process, high in repeatability and suitable for industrial production. The mixed micelle does not need to be solubilized by ethanol, propylene glycol and other organic solvents with large stimulation, and the obtained mixed micelle has no side effect in use, is safe and reliable, and has the advantages of wide raw material source and low cost. The invention further discloses application of the mixed micelle, the mixed micelle can be used for preparing cosmetics and preparing pharmaceutical compositions from the mixed micelle and pharmaceutically acceptable pharmaceutic adjuvants, the lipoic acid mixed micelle can be prepared into injections, oral preparations and skin coatings and can be used after being diluted to different degrees, and clinical administration is greatly facilitated.

The invention discloses a nimodipine micelle injection and a preparation method thereof. The nimodipine micelle injection is prepared by using active ingredients, i.e. nimodipine and phospholipid / bile salt. According to the nimodipine micelle injection disclosed by the invention, the solubility of the nimodipine is greatly increased, and no crystal precipitation exists when the nimodipine micelle injection is diluted; the biocompatibility of the phospholipid / bile salt is good, and organic solvents with great toxic side effects, such as ethyl alcohol, propylene glycol and the like, are not needed to for solubilizing so that the toxicity of the nimodipine micelle injection is lowered, the vascular stimulation is little, and the adverse reaction of the nimodipine micelle injection is reduced; and the nimodipine micelle injection can be directly used for intravenous injection and can also be used for instilling after the nimodipine micelle injection is diluted to various degrees, and thus, the clinical administration is greatly facilitated.

The invention relates to a medicinal composition for treating complex infection and a preparation method thereof. The medicinal composition is characterized by comprising an active ingredient selected from one of glycopeptides antibacterial drugs of telavancin, dalbavancin, oritavancin, vancomycin, teicoplanin or a pharmaceutically acceptable salt thereof, and also comprising polyene and echinocandin type antifungal agents, and being prepared into a freeze-dried powder injection by adopting a conventional process. The medicinal composition provided by the invention realizes combined application of the antibacterial drugs and the antifungal agents, can simultaneously give play to an antibacterial infection effect and an antifungal infection effect, and is convenient for clinical use.

The invention discloses pimobendan sustained-release tablets for a pet and a preparation method thereof. The pimobendan sustained-release tablets disclosed by the invention are stable and safe to use and consist of a solid dispersion of pimobendan, a sustained-release material, a filling agent, an adhesive, a lubricant and a flavoring agent. The pimobendan sustained-release tablets disclosed by the invention have the characteristics of convenience in administration, lasting action and stable curative effect.

The invention relates to a new veterinary medicine preparation (sulfamonomethoxine suspension injection or sulfamonomethoxine sodium suspension injection) and a preparation method thereof; the new veterinary medicine preparation is prepared by taking sulfamonomethoxine or sulfamonomethoxine sodium as main drug and other excipients for assist. The percentage of the main ingredients in the suspension is as follows: 1%-50% (W / V) of sulfamonomethoxine or sulfamonomethoxine sodium and the rest of drug excipients; the excipients include a suspending agent and a disperse medium. The invention takes oil solvent as the disperse medium to prepare sulfamonomethoxine or sulfamonomethoxine sodium into a long-acting and sustained-release preparation; by adopting intramuscular injection for drug administration, the in vivo acting time of the drug can be significantly prolonged, the times of drug administration are reduced and the blood concentration of diseased livestock can keep stable. The new veterinary medicine preparation of the invention is safe, stable, effective and controllable in quality, thus being widely applicable to the treatment of bacterial infection and parasitic infestation in livestock.

The invention relates to the technical field of veterinary medicines, in particular to a preparation technology for compound solution of florfenicol and doxycycline. The preparation technology has the advantages that since the solution is prepared from doxycycline hydrochloride, stress reaction of livestock and poultry is reduced during dosing, contact area of medicine and the absorption part is enlarged, release of the medicine in an acid environment of the stomach is reduced by means of complexation of magnesium ions and the doxycycline hydrochloride, stimulus of the doxycycline hydrochloride to gastric mucosa is avoided effectively, the medicine is transferred to the absorption part of the small intestine directly, and clinical medicinal value of the doxycycline is increased; the florfenicol is added into a doxycycline hydrochloride solution, and the problem of solubility of the florfenicol is solved by the aid of different proportions of corresponding solvents and employing of solubilizing agents.

The invention provides a gastric retention long acting preparation and a preparation method thereof. The gastric retention long acting preparation comprises a gastric coated capsule shell and a medicine release unit, wherein the medicine release unit is folded into a geometric shape to be arranged in the gastric coated capsule shell and comprises a capillary member and a biology biodegradable connecting fitting, two ends of the capillary member are closed and one or more medicine release holes are formed in the wall of a pipe, and medicines are placed in the medicine release holes; and the biology biodegradable connecting fitting is used for enabling two ends of the capillary member to be connected. The preparation method is simple, the gastric retention long acting preparation is smooth in medicine release rate, and the medicine release holes of different numbers and different diameters are formed in the capillary member to regulate the medicine release rate and the medicine release time. The degradation time of the biology biodegradable connecting fitting is used for controlling the residence time of the preparation in the gaster.

The invention discloses ciprofloxacin thermo-sensitive type in-situ gel composition and belongs to the field of veterinary drug preparations. The thermo-sensitive type in-situ gel composition comprises, by weight volume (g / ml), 5%-10% of ciprofloxacin, 20%-26% of poloxamer 407, 0.5%-10% of poloxamer 188, 0.01%-0.04% of edetic acid, 0.009%-0.03% of bacteriostatic agent, and 0.1%-0.2% of antioxidant. Solvent of the composition is acetic acid - sodium acetate buffer solution. The invention further discloses a preparing method of the composition. The ciprofloxacin thermo-sensitive type in-situ gel composition is liquid at room temperature, jelling temperature is close to body temperature, and therefore dosing is convenient and jelling speed is high, jelling strength and adhering function are good, the dosing can be achieved with accurate positioning, and loss of drug is reduced. Furthermore, the ciprofloxacin thermo-sensitive type in-situ gel composition and the preparing method thereof have controlled-releasing and long-acting functions, dosage is low, the number of times of dosing is small, harm caused by implants normally used is avoided, and pain of patients is relieved.

The invention discloses a medicinal composition containing lentinan. The medicinal composition comprises, by weight, 0.5-5% of lentinan, 1-10% of yeast glucan, 2-10% of levamisole hydrochloride, 5-30% of licorice root extract, and the balance of anhydrous glucose. The invention also discloses a preparation method of the medicinal composition, and a use of the composition in enhancement of the immunity of animals. The medicinal composition which is processed through an ultrafine crushing technology has a high medicine absorption rate, substantially promotes the growth of animal immune organs and enhances the immunity of animal bodies; the medicinal composition has a substantial curative effect on viral disease induced immunosuppression and poor immunity, and substantially reduces the mortality of pathogenetic animals; the medicinal composition substantially increases the antibody tilter of vaccine immunized serum of the animals in order to substantially enhance the vaccine immunization effect; and the composition has the advantages of simple production steps, convenience in clinic use, and convenience in colony administration.

The present invention relates to a pharmaceutical composition, comprising liquid oil, at least one compound represented by the following formula I, and at least one pharmaceutically active ingredient. The pharmaceutical composition can be used in a sustained-release formulation system, so that the drug is in a semi-solid or solution form at room temperature, the semi-solid formulation can be directly used as a drug reservoir at the administration site, and the liquid formulation is in contact with the body fluid at the administration site. A phase transition occurs to form a drug depot, while improving drug safety and tolerability.

The invention relates to a novel veterinary preparation, namely sulfamonomethoxine suspension injection or sulfamonomethoxine sodium suspension injection, and a preparation method thereof. The preparation is prepared by using sulfamonomethoxine or sulfamonomethoxine sodium as a main drug and other auxiliary materials. The suspension injection comprises 1-45 percent (W / V) of the main component sulfamonomethoxine or sulfamonomethoxine sodium and medicinal auxiliary materials, wherein the auxiliary materials comprise a suspending agent, dispersion medium and an antioxidant. According to the preparation method, a long-acting sustained-release preparation is prepared from sulfamonomethoxine or sulfamonomethoxine sodium by using an oily solvent as a dispersion medium, is administrated in an intramuscular injection mode, can be used for remarkably prolonging the time of drug action in a body and reducing the number of administration times, and provides a stable plasma concentration to ill livestock. The suspension injection is safe, stable, effective and controllable in quality, and can be widely applied to livestock bacterial infection and parasitic infection.

The invention relates to a traditional Chinese medicine microcapsule for preventing and treating recessive mastitis of dairy cows and a preparation method of the traditional Chinese medicine microcapsule. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 25-30 parts of lonicerae flos, 25-36 parts of edible tulip, 60-80 parts of wild buckwheat rhizome, 80-120 parts of oldenlandia diffusa, 15-25 parts of dandelion and 45-60 parts of radix angelicae sinensis. The traditional Chinese medicine microcapsule hasa remarkable effect on treating recessive mastitis of the dairy cows, the medicine stability can be improved by adopting a micro-capsule coating technology, and the stability of a clinical curative effect is ensured; bad smell of traditional Chinese medicine is covered, and palatability is improved; and the rumen bypass loss is reduced, the bioavailability is improved, the medicine dosage is low,and adverse reactions are few.

The invention relates to a fluoroquinolone antibiotic capsule for pets and a preparation method thereof, belonging to the technical field of pet medicine. The capsules of the present invention are composed of capsule contents and capsule shells. The content of the capsule includes a pill core and a coating liquid, wherein the components in the pill core and their weight percentages are: 60.0-90.0% of fluoroquinolone antibiotics, 1.0-5.0% of adhesive, 5.0-39.0% of filler, The weight percent composition of the coating liquid is: coating powder 97.0-99.8%, lubricant 0.1-2.0%, stabilizer 0.1-2.0%. The invention is mainly applied to the prevention and treatment of gram-positive bacteria, negative bacteria, mycoplasma and mycoplasma in pet dogs and cats, and has the advantages of broad-spectrum sterilization, good palatability, rapid action, remarkable curative effect, convenient use and the like.

The invention belongs to the technical field of processing and biotransformation of traditional Chinese veterinary medicines, and in particular relates to a fermented traditional Chinese medicine preparation for promoting estrus in sows and a preparation method thereof. The traditional Chinese medicine fermentation preparation for promoting estrus in sows includes the following raw materials in parts by weight: 3-13 parts of Eucommia ulmoides, 3-13 parts of Ligustrum lucidum, 8-18 parts of Angelica sinensis, 3-13 parts of Codonopsis pilosula, 8-18 parts of Motherwort 3-13 parts of Chuanxiong, 3-13 parts of Astragalus, 3-13 parts of soybean, 3-13 parts of Cuscuta, 3-13 parts of bile acid, 1-7 parts of vitamin E, 1-7 parts of Candida utilis, 1-7 parts of lactic acid bacteria, 5-20 parts of glucose. The traditional Chinese medicine preparation of the invention has high bioavailability, can significantly improve sow estrus, and can effectively treat sow non-estrus at the same time.

The invention belongs to the technical field of pharmaceutical preparations, and discloses a soluble hiruzenone hydrobromide powder and a preparation method thereof. It is made of the following raw materials in weight percent: 0.6-2% hemosanone hydrobromide, 2.0-30.0% emulsifier, 1.0-20.0% co-emulsifier, and 50.0-90.0% soluble solid adsorption material. Preparation method: Mix hiruzenone hydrobromide, emulsifier and co-emulsifier uniformly at 40-70°C, pass through colloid mill treatment, and cool to room temperature to obtain hiradhenone hydrobromide self-emulsifying concentrate; water-soluble solid After the adsorption material is pulverized, it is uniformly mixed with the hydrobromide self-emulsifying concentrate to obtain a semi-solid; the semi-solid is dried and pulverized to obtain a hydrobromide soluble powder. The hydrobromide soluble powder prepared by the present invention has water solubility, not only solves the problem of clinical drinking water administration, but also has advantages and is more convenient than the liquid hydrobromide solution in terms of packaging, carrying, and transportation. It has a good application prospect for treating coccidiosis.

The invention discloses a veterinary drug composition containing traditional Chinese medicine components and a preparation method of the veterinary drug composition, and relates to the technical field of veterinary drug compositions.The veterinary drug composition is mainly prepared from the following raw materials: glucose oxidase, glutathione, pyrantel, decoquinate, astragalus membranaceus, honeysuckle, fructus forsythiae, pseudo-ginseng, salvia miltiorrhiza, angelica sinensis, houttuynia cordata, polyporus umbellatus, ligusticum wallichii, codonopsis pilosula, enzyme-producing probiotics and mannitol. According to the veterinary drug composition containing the traditional Chinese medicine components, various specific types of components are adopted and matched according to specific dosage, the novel veterinary drug composition containing the traditional Chinese medicine components is finally formed, all the components are matched and coordinated, the body balance can be adjusted, and the veterinary drug composition is suitable for enhancing the disease resistance and immunity of livestock. The veterinary drug composition can significantly improve the organism immunity of livestock and poultry and enhance the disease resistance; and the veterinary drug composition has a good inhibition effect on viral diseases, and reduces the death rate of livestock and poultry remarkably.

The invention relates to a traditional Chinese medicine perfusate for treating female endometritis and a preparation method thereof. The traditional Chinese medicine composition of the invention is composed of purslane, rehmannia glutinosa, Guiwei, achyranthes bidentata, Pollen Pollen, Cortex Moutan and Corydalis Corydalis, and auxiliary materials include pH regulator, osmotic pressure regulator and preservative. The composition of the drug in the raw material of the present invention is formed through systematic compatibility research, and has obvious and outstanding synergistic effects. The preparation method thereof can significantly improve the activity of the drug, reduce toxic and side effects, have high bioavailability of the drug, and facilitate clinical administration, etc. .

The invention discloses a compound preparation for cleaning toxins in pig bodies and a preparation method of the compound preparation, wherein the compound preparation comprises the components in parts by weight: 1-2 parts of selenium yeast, 1-2 parts of chromium picolinate, 10-20 parts of glutamine, 10-20 parts of arginine, 10-20 parts of guanidinoacetic acid, 10-20 parts of aflatoxin B1 clastic enzyme for feeds, 10-20 parts of saccharomyces cerevisiae culture, 10-20 parts of acanthopanax and 10-20 parts of astragalus membranaceus. According to the formula, the immunity and production performance of pigs can be improved by cleaning toxins in the pigs, the toxins in the pigs are cleaned according to the physiological characteristics of the pigs, and the compound preparation is prepared by selecting green raw materials, is safe and effective, and is free of residues and drug resistance.

The invention belongs to the technical field of traditional Chinese veterinary medicine processing and biotransformation, and particularly relates to a traditional Chinese medicine fermentation preparation for promoting sow oestrus and a preparation method thereof. The traditional Chinese medicine fermentation preparation for promoting sow oestrus comprises the following raw materials in parts by weight: 3-13 parts of eucommia ulmoides, 3-13 parts of glossy privet fruit, 8-18 parts of angelica sinensis, 3-13 parts of codonopsis pilosula, 8-18 parts of motherwort, 3-13 parts of ligusticum wallichii, 3-13 parts of astragalus membranaceus, 3-13 parts of soybeans, 3-13 parts of semen cuscutae, 3-13 parts of bile acid, 1-7 parts of vitamin E, 1-7 parts of candida utilis, 1-7 parts of lactic acid bacteria and 5-20 parts of glucose. The traditional Chinese medicine preparation disclosed by the invention is high in bioavailability, has a remarkable improvement effect on sow oestrus, and can be used for effectively treating non-oestrus of sows.