Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicinal composition for treating complex infection and preparation method of medicinal composition

A combined infection and composition technology, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems of inconvenient clinical use, long treatment time, and pain of administration

Inactive Publication Date: 2015-09-09
SHENZHEN JYMED TECH
View PDF4 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no clinical preparation for the treatment of combined infection. The antibacterial infection and antifungal infection programs are administered separately. The repeated and alternate use of the two types of drugs makes the administration cumbersome and the treatment time is long, which brings inconvenience to clinical use. Also bring the misery of administration to the patient, therefore, urgently need a kind of pharmaceutical composition that can bring into play the effect of antibacterial infection and antifungal infection simultaneously, facilitate clinical use, improve patient's adaptability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition for treating complex infection and preparation method of medicinal composition
  • Medicinal composition for treating complex infection and preparation method of medicinal composition
  • Medicinal composition for treating complex infection and preparation method of medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Telavancin hydrochloride 250g (calculated as telavancin), anidulungin 50g, mannitol 300g, hydrochloric acid buffer in proper amount.

[0012] The preparation process is as follows: accurately weigh the prescribed amount of telavancin hydrochloride and anidifungin, add an appropriate amount of water for injection to dissolve; add the prescribed amount of mannitol and hydrochloric acid buffer to the above solution in sequence, and adjust the pH to 5.0 , and then use a 0.1μm ultrafiltration membrane to remove the heat source, the filtrate is sterilized and filtered through a 0.22μm microporous membrane, add water for injection to make up to 15L, and then divide it into 1000 bottles, freeze-dry, press the stopper, roll the cap, and pass the inspection Labeled and packaged to obtain the powder for injection of the composition.

[0013] Investigate the therapeutic effect of the pharmaceutical composition lyophilized powder preparation prepared in Example 1 and the commerciall...

Embodiment 2

[0023] Vancomycin hydrochloride 100g (calculated as telavancin), amphotericin B 125g, mannitol 300g, appropriate amount of hydrochloric acid buffer.

[0024] The preparation process is as follows: accurately weigh the prescribed amount of vancomycin hydrochloride and amphotericin B, add an appropriate amount of water for injection to dissolve; add the prescribed amount of mannitol and hydrochloric acid buffer to the above solution in turn, adjust the pH to 5.0, Finally, use a 0.1 μm ultrafiltration membrane to remove the heat source, and the filtrate is sterilized and filtered through a 0.22 μm microporous membrane, and then added water for injection to make up to 25L, then divided into 1000 bottles, freeze-dried, plugged, and capped, and pasted after passing the inspection Sign the package to get the powder for injection of the composition.

[0025] Investigate the therapeutic effect of the pharmaceutical composition lyophilized powder preparation prepared in Example 2 and th...

Embodiment 3

[0035] Dalbavancin hydrochloride 500g (calculated as dalbavancin), caspofungin acetate 250mg (calculated as caspofungin), lactose 150g, mannitol 150g, appropriate amount of tartrate buffer.

[0036] The preparation process is as follows: accurately weigh the prescribed amount of dalbavancin hydrochloride and caspofungin acetate, add an appropriate amount of water for injection to dissolve; sequentially add the prescribed amount of mannitol, lactose, and tartrate buffer to the above solution, adjust pH to 5.2, then use 0.1μm ultrafiltration membrane to remove heat source, the filtrate is sterilized and filtered through 0.22μm microporous membrane, add water for injection to make up to 25L, then divide into 1000 bottles, freeze-dry, press stopper, roll cap, After passing the inspection, the powder for injection of the composition is obtained by labeling and packaging.

[0037]Investigate the therapeutic effect of the pharmaceutical composition freeze-dried powder preparation pre...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a medicinal composition for treating complex infection and a preparation method thereof. The medicinal composition is characterized by comprising an active ingredient selected from one of glycopeptides antibacterial drugs of telavancin, dalbavancin, oritavancin, vancomycin, teicoplanin or a pharmaceutically acceptable salt thereof, and also comprising polyene and echinocandin type antifungal agents, and being prepared into a freeze-dried powder injection by adopting a conventional process. The medicinal composition provided by the invention realizes combined application of the antibacterial drugs and the antifungal agents, can simultaneously give play to an antibacterial infection effect and an antifungal infection effect, and is convenient for clinical use.

Description

Technical field: [0001] The invention belongs to the technical field of medicine preparation, and specifically relates to a composition containing glycopeptide antibacterial medicines and antifungal medicines and a preparation method thereof. Background technique: [0002] With the wide application of antibiotics, antineoplastic drugs, immunosuppressants and traumatic diagnosis and treatment techniques and the increase in the incidence of immunodeficiency syndrome, the number of patients with bacterial and fungal co-infection is increasing. For example, patients with hematological tumors, diabetes, and AIDS often have bacterial and fungal infections. Pathogens are often Candida albicans, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus enterica, etc., and most of them are multi-drug resistant bacteria. Treatment is very tricky, causing the disease to worsen and the mortality rate to increase. [0003] Glycopeptide antimicrobials vancomycin and teicoplanin a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K38/12A61K38/14A61K31/7048A61P31/10A61P31/04
CPCA61K38/14
Inventor 支钦李新宇张建松舒遂智马洪季黄秋霞
Owner SHENZHEN JYMED TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com