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Preparation method of Sihuang heart-clearing concentrated pills

A technology of concentrated pills and rhubarb, which is applied in the direction of medical preparations containing active ingredients, pill delivery, and pharmaceutical formulations, can solve the problems of slow release of active ingredients, low bioavailability, and inapplicability to diabetic patients, so as to avoid honey. The effect of using and expanding the scope of application

Active Publication Date: 2019-08-16
沈阳清宫药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the problem that honey is used as a binder in the preparation method of Sihuang Qingxin Pills in the prior art, so that it cannot be applied to diabetic patients, and the preparation of crude drug powder leads to slow release of active ingredients and low bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A preparation method of Sihuang Qingxin Concentrated Pills, the specific preparation process is as follows:

[0036] Feed with 500 times the prescription amount. Crush the rhubarb into 5-10mm coarse particles, cut the licorice into small pieces of 1-3cm, crush the gardenia, put it into a 6T straight extraction tank, add 4024kg of drinking water, soak for 0.5h, turn on the steam heating, wait After the liquid boils, add Scutellaria baicalensis medicinal material, keep boiling slightly for 2 hours, turn off the steam, and filter the liquid medicine for later use; then add 3018 kg of drinking water, turn on the steam for heating, keep boiling slightly for 1.5 hours, turn off the steam, and filter the liquid medicine. Combine the above medicinal liquids, pour them into a 2000-type double-effect concentrator, control the vacuum degree of the first effect at 0.035-0.045MPa, and the temperature at 78-83°C; The specific gravity is 1.12.

[0037] Cut Cortex Phellodendron into ...

Embodiment 2

[0052] A preparation method of Sihuang Qingxin Concentrated Pills, the specific process is:

[0053] Feed with 500 times the prescription amount. Crush the rhubarb into 5-10mm coarse particles, cut the licorice into small pieces of 1-3cm, crush the gardenia, put it into a 6T straight extraction tank, add 4024kg of drinking water, soak for 0.5h, turn on the steam heating, wait After the liquid boils, add Scutellaria baicalensis medicinal material, keep boiling slightly for 2 hours, turn off the steam, and filter the liquid medicine for later use; then add 3018 kg of drinking water, turn on the steam for heating, keep boiling slightly for 1.5 hours, turn off the steam, and filter the liquid medicine. Combine the above medicinal liquids, pour them into a 2000-type double-effect concentrator, control the vacuum degree of the first effect at 0.035-0.045MPa, and the temperature at 78-83°C; The specific gravity is 1.32.

[0054] Cut Cortex Phellodendron into 2-5mm filaments, put it...

Embodiment 3

[0064] A preparation method of Sihuang Qingxin Concentrated Pills, the specific process is:

[0065] Feed with 500 times the prescription amount. Crush the rhubarb into 5-10mm coarse particles, cut the licorice into small pieces of 1-3cm, crush the gardenia, put it into a 6T straight extraction tank, add 2921kg of drinking water, soak for 2 hours, turn on steam heating, wait for the liquid After boiling, add Scutellaria baicalensis medicinal materials, keep boiling slightly for 1.5 hours, turn off the steam, and filter the medicinal solution for later use; then add 3018kg of drinking water, turn on the steam heating, keep slightly boiling for 0.5h, turn off the steam, and filter the medicinal solution; then add 3018kg of drinking water , turn on the steam to heat, keep boiling slightly for 1h, turn off the steam, and filter the liquid medicine. Combine the above medicinal liquids, put them into the 2000 type double-effect concentrator, control the first-effect vacuum degree a...

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Abstract

The invention discloses a preparation method of Sihuang heart-clearing concentrated pills, and solves the problems that Sihuang heart-clearing concentrated pills in the prior art cannot be suitable for diabetic patients because honey is used as an adhesive in a preparation method of the Sihuang heart-clearing concentrated pills and effective ingredients are released slowly and the bioavailabilityis low because raw drug powder is used for preparation. The concentrated pills are prepared by extracting and concentrating a part of medicinal materials in a prescription and adding the remaining part of medicinal powder through a plastic molding or generic processing method. The method no longer uses honey as a drug excipient, so that the medicine increases the applicable population; meanwhile,the release speed and the bioavailability of the concentrated pills are obviously higher than those of large honey pills in the prior art.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a preparation method of Sihuang Qingxin Concentrated Pills. Background technique [0002] Sihuang Qingxin Pill is a brown to tan large honeyed pill. It has the functions of clearing away heat, detoxifying, and refreshing. . The specific composition and preparation method of Sihuang Qingxin Pills are recorded in the "National Standards Compilation of Chinese Patent Medicine Meridians, Limbs and Brain System, Page Number: GJN─246", Standard Number: WS-10014(ZD-0014)-2002. [0003] The specific prescription of Sihuang Qingxin pills is: artificial bezoar 15g, Phellodendron 402g, Scutellaria baicalensis 402g, rhubarb 201g, talc 201g, licorice 201g, cinnabar 80g, gardenia 135g, gypsum 268g, borneol 28g. The specific production method is to grind artificial bezoar and borneol into fine powder, fly cinnabar water into a very fine powder, and crush the rest of the medicinal materials...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/20A61P1/10A61P29/00A61K31/045A61K33/06A61K33/12A61K33/28A61K35/413
CPCA61K9/20A61K31/045A61K33/06A61K33/12A61K33/28A61K35/413A61K36/484A61K36/539A61K36/708A61K36/744A61K36/756A61K2236/331A61K2236/333A61K2236/39A61P1/10A61P29/00A61K2300/00
Inventor 刘锦杨金敏王永建
Owner 沈阳清宫药业集团有限公司
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