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Manidipine hydrochloride tablets and preparation method thereof

A technology of manidipine hydrochloride and manidipine hydrochloride, which is applied in the direction of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as unfavorable absorption and degradation, and achieve improved dissolution rate, good stability, and preparation The effect of simple method

Inactive Publication Date: 2015-03-25
XUCHANG HENGSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, as a dihydropyridine calcium antagonist, manidipine hydrochloride has photostability, and there is a possibility of degradation under light conditions.
At the same time, it is also a poorly soluble drug, which is not conducive to being absorbed by the human body in clinical practice.

Method used

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  • Manidipine hydrochloride tablets and preparation method thereof
  • Manidipine hydrochloride tablets and preparation method thereof
  • Manidipine hydrochloride tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: manidipine hydrochloride tablet (specification 20mg)

[0028] prescription:

[0029]

[0030] The above tablets are prepared according to the following method: first disperse manidipine hydrochloride, half the amount of colloidal silicon dioxide and crospovidone in water; then add the remaining colloidal silicon dioxide, starch , microcrystalline cellulose, erythritol and riboflavin, mixed evenly, and granulated by wet method; the wet granule material was dried and sieved; magnesium stearate was added to the sieved dry granules and mixed evenly ; Finally, the resulting mixture is compressed into manidipine hydrochloride tablets.

Embodiment 2

[0031] Embodiment 2: manidipine hydrochloride tablet (specification 10mg)

[0032] prescription:

[0033]

[0034] The above tablets are prepared according to the following method: first disperse manidipine hydrochloride, half the amount of colloidal silicon dioxide and crospovidone in water; then add the remaining colloidal silicon dioxide, starch , microcrystalline cellulose, lactose monohydrate and riboflavin, mix well, and use wet granulation; dry the wet granule material and sieve; add magnesium stearate to the sieved dry granule and mix uniform; finally the resulting mixture is compressed into manidipine hydrochloride tablets.

Embodiment 3

[0035] Embodiment 3: the preparation of manidipine hydrochloride tablet (specification 5mg)

[0036] prescription:

[0037]

[0038] The above tablet was prepared according to the following method:

[0039] First disperse manidipine hydrochloride, half of the amount of colloidal silicon dioxide and crospovidone in water; then add the remaining colloidal silicon dioxide, starch, microcrystalline cellulose, lactose to the formed suspension Hydrate and riboflavin, mixed uniformly, and wet granulated; the wet granulated material was dried and sieved; magnesium stearate was added to the sieved dry granules and mixed uniformly; Nidipine tablet.

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PUM

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Abstract

The present invention discloses manidipine hydrochloride tablets and a preparation method thereof, wherein manidipine hydrochloride is adopted as the active component, an effective amount of colloidal silica is adopted as the drug excipient for improving the dissolution rate, and riboflavin for improving the stability is adopted as the stabilizer. According to the present invention, the light instability and the insolubility of the manidipine hydrochloride are overcome so as to improve the stability and the dissolution rate of the manidipine hydrochloride tablets.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a manidipine hydrochloride tablet for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is one of the most common cardiovascular diseases in the world today. There are many types of drugs currently used to treat hypertension, such as: diuretic antihypertensive drugs, central antihypertensive drugs, vasodilators, β-receptor blockers Drugs, α-receptor blockers, calcium channel blockers (CCB), angiotensin-converting enzyme inhibitors (ACEI), AngII receptor antagonists, etc. [0003] Manidipine hydrochloride is a third-generation dihydropyridine L-type, T-type calcium ion dual channel antagonist, used for the treatment of mild to moderate hypertension, it can inhibit the smooth muscle cell voltage-dependent calcium ion influx, causing systemic Blood vessels dilate, thereby lowering blood pressure. It has the follo...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/496A61K47/04A61K47/22A61P9/12
Inventor 蚩晓娜吕亚军徐安娜谷志勇郭培
Owner XUCHANG HENGSHENG PHARMA
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