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Chinese medicinal herb for treating tristimania and preparation method thereof

A technology for depression and traditional Chinese medicine preparations, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, can solve the problems of obvious long-term side effects and limited depression effects of Chinese patent medicines, and achieves improved bioavailability, The effect of rational drug prescription and significant curative effect

Active Publication Date: 2012-06-27
SHENZHEN HUIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned chemically synthesized drugs have significant antidepressant effects, they have obvious side effects after long-term use, while the existing Chinese patent medicines have limited antidepressant effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Ghana grain 1100g, Hypericum perforatum 1100g, Angelica 600g, Hawthorn 600g, Curcuma 500g, Acanthopanax 500g, Chuanxiong 300g, Rehmannia glutinosa 300g

[0044] Take the above medicinal materials, add 35kg of normal water to soak for 1 hour, heat (70°C) for 2 hours, filter, and the filtrate is set aside, add 25kg of normal water to the medicinal residue, heat (70°C) for 2 hours, filter, and combine the two batches of filtrate, Heat and concentrate in vacuum (0.098MPa) to a relative density of 1.15 (60°C), add 75% ethanol to ethanol content of 35% (w / w), let stand for 8 hours, filter, and concentrate the filtrate in vacuum (0.15MPa) (70°C) Recover ethanol, continue heating to a relative density of 1.28 (60°C) to obtain an extract, crush the extract, add an appropriate amount of soft material made of starch and absolute ethanol, pass through a 40-mesh sieve, dry at 60°C, and pass the granules through a 60-mesh Sieve, add appropriate amount of talcum powder, magnesium stea...

Embodiment 2

[0046] Ghana grain 1200g, Hypericum perforatum 1000g, Angelica 750g, Hawthorn 450g, Curcuma 550g, Acanthopanax 450g, Chuanxiong 200g, Rehmannia glutinosa 400g

[0047]Take the above medicinal materials, add 35kg of normal water to soak for 8 hours, heat (70°C) for 2 hours, filter, and the filtrate is set aside, add 25kg of normal water to the medicinal residues, heat (70°C) for 2 hours, filter, and combine the two batches of filtrate, Heat and concentrate in vacuum (0.098MPa) to a relative density of 1.15 (60°C), add 75% ethanol to ethanol content of 35% (w / w), let stand for 8 hours, filter, add appropriate amount of aspartame and potassium sorbate, Stir evenly, filter, add deionized water to the filtrate to 10000ml, pack separately, and obtain the traditional Chinese medicine oral liquid of the present invention.

Embodiment 3

[0049] Ghana grain 1400g, Hypericum perforatum 800g, Angelica 500g, Hawthorn 700g, Curcuma 400g, Acanthopanax 600g, Chuanxiong 250g, Rehmannia glutinosa 350g

[0050] Take the above medicinal materials, add 35kg of normal water to soak for 1 hour, heat (70°C) for 2 hours, filter, and the filtrate is set aside, add 25kg of normal water to the medicinal residue, heat (70°C) for 2 hours, filter, and combine the two batches of filtrate, Heat (70°C) in vacuum (0.098MPa) and concentrate to a relative density of 1.15 (60°C), add 75% ethanol to an alcohol content of 35% (w / w), let stand for 8 hours, filter, and vacuum the filtrate (0.15MPa) Concentrate (70°C) to recover ethanol, spray dry to obtain dry granules, add appropriate amount of lactose, appropriate amount of talcum powder, mix evenly, fill into capsules, and obtain the traditional Chinese medicine capsule of the present invention.

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PUM

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Abstract

The invention provides a Chinese medicinal herb for treating a tristimania and preparation method thereof. The Chinese medicinal herb is prepared to an oral preparation by the following steps of: taking Ghananian grains, hypericum perforatum, angelica sinensis, hawthorn, radix curcumae, acanthopanax senticosus, ligusticum wallichii and rehmannia as raw materials, extracting and concentrating the raw materials and adding a proper amount of drug excipient. According to the principle of the Chinese medicinal herbs, the Chinese medicinal herb disclosed by the invention is screened through tests for many years. The raw material drugs in a prescription are selected, the preparation process is optimized, and the Chinese medicinal herb disclosed by the invention has obvious restraining, remission and treatment effects on the depressive symptoms of a patient suffering from tristimania without any side effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine for treating depression and a preparation method thereof. Background technique [0002] Depression is an affective mental disorder, and it is a syndrome characterized by significant and persistent low mood, mainly manifested as social passivity, decreased aggressiveness, and life evacuation. Depression seriously affects people's quality of life, leading to a decline in work efficiency, and negative suicide behaviors may occur in severe patients. With the rapid development of modern society and the increase of people's mental stress, the incidence of depression has increased year by year, and it has become an epidemic in the 21st century, and the incidence has a tendency to increase year by year. The World Health Organization pointed out in the "2001 World Health Report" that depression has become the fourth largest disease in the world, and by 2020 it may become the second largest disease after i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P25/24
Inventor 刘洋孔徐生李冬丁国华欧荔枝付莹孔翔雷江凌
Owner SHENZHEN HUIMIN PHARMA
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