Preparation method and application of Nepeta bracteatatotal flavonoids

A technology for total flavonoids of Nepeta buds and total flavonoids is applied in the field of extraction and preparation of total flavonoids from Nepeta buds. Progress, good repeatability, no environmental pollution effect

Inactive Publication Date: 2017-02-22
XINJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, no literature has been found on the preparation method, pharmacological activity and medicinal use of the total flavonoids of Schizonepetae

Method used

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  • Preparation method and application of Nepeta bracteatatotal flavonoids
  • Preparation method and application of Nepeta bracteatatotal flavonoids
  • Preparation method and application of Nepeta bracteatatotal flavonoids

Examples

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Effect test

Embodiment 1

[0014] The Schizonepetae medicinal material that selects is dried whole herb, and uses after being pulverized through a 20-mesh sieve; the Schizonepeta sieve sifted is placed in a 10L round-bottomed flask, and the volume percentage concentration is 60% ethanol / water to extract, Ethanol / water is 6 times the weight of the medicinal material of Schizonepetae, heated in a water bath to 70°C, extracted once under reflux, the extraction time is 2h, the extract is filtered, and the filtrate is concentrated under reduced pressure to 1.0 g crude drug / mL to obtain Schizonepeta schizonepeta Extract solution: dilute the extract of Nepeta schizonepeta with 1 times the amount of water, let it stand for 12 h, remove insoluble substances by suction filtration, and concentrate the filtrate to 1.0 g crude drug / mL; The macroporous adsorption resin was used for adsorption. The weight ratio of Schizonepeta macroporous and macroporous adsorption resin was 1:1, the concentration of flavonoids in the ...

Embodiment 2

[0016] The Schizonepetae medicinal material that selects is dried whole grass, uses after being crushed through a 20-mesh sieve; the Schizonepeta sieve sifted is placed in a 10L round-bottomed flask, and the volume percentage concentration is 70% ethanol / water to extract, Ethanol / water is 8 times the weight of Nepeta schizonepeta medicinal material, heated to 80°C in a water bath, refluxed and extracted 3 times for 1 hour, the extract was filtered, and the filtrate was concentrated under reduced pressure to 0.25 g of crude drug / mL to obtain Vitex sphaerae mustard extract. Dilute the extract of Schizonepetae with 3 times the amount of water, let it stand for 18 hours, remove the insoluble substances by suction filtration, and concentrate the filtrate to 0.25 g crude drug / mL; extract the Schizonepeta schizonepeta through the macropores of AB-8 The resin was used for adsorption. The weight ratio of Schizonepeta maculatum and macroporous adsorption resin was 1:4, the concentration...

Embodiment 3

[0018] The Schizonepetae medicinal material that selects is dry whole grass, uses after being pulverized through 20 mesh sieves; The Schizonepeta Schizonepetae that sieves is placed in the 10L round bottom flask, adopts volume percentage concentration to be that 75% ethanol / water extracts, Ethanol / water is 10 times the weight of the herb Nepeta chinensis, heated to 60°C in a water bath, extracted twice under reflux for 3 hours, filtered the extract, and concentrated the filtrate to 0.5 g crude drug / mL under reduced pressure to obtain Vitex sphaerae mustard extract. Dilute the extract of Schizonepetae with 2 times the amount of water, let it stand for 24 hours, remove the insoluble matter by suction filtration, and concentrate the filtrate to 0.5 g crude drug / mL; extract the Schizonepeta extract, and absorb it through the macropores of HPD-600 The resin was used for adsorption. The weight ratio of Schizonepeta maculatum and macroporous adsorption resin was 1:6, the concentratio...

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Abstract

The invention provides a preparation method and application of Nepeta bracteata total flavonoids. The method comprises the steps of conducting extraction with hydrous ethanol to the Uygur Nepeta bracteata, conducting macroporous resin enrichment to acquire the Nepeta bracteata total flavonoids. The total flavonoids content accounts for no less than 68% of the Nepeta bracteata total flavonoids extracts. The Nepeta bracteata total flavonoids have the functions of anti-inflammation, anti-coughing, phlegm elimination and asthma relief. The preparation with Nepeta bracteata total flavonoids as the main material, and with the incorporation of a variety of additional drug excipients, can be used for the therapy of influenza, pneumonia, bronchitis and asthma. The preparation method has the advantages of being simple and safe, being good in repeatability, and having no pollution, thus being suitable for large scale production.

Description

technical field [0001] The invention relates to the extraction of Chinese medicinal materials, and the method is especially suitable for the extraction and preparation of the total flavonoids of Schizonepetae. Background technique [0002] Nepeta bracteata Benth is the dry whole herb of Nepeta bracteata Benth, a plant of the Labiatae family. It is a commonly used medicinal material in Uyghur medicine. The classic medical book "Alicanon" has a history of more than 800 years, "Yihe Tiyalati Baidiyi" has a history of more than 650 years, and "Maikesan Aidiwei" has a history of more than 500 years. It is recorded in classical medical books that Schizonepeta schipeta produces dryness and heat, warms the lungs and relieves asthma, dispels cold and relieves cough, dries dampness and phlegm, sweats and detoxifies, reduces inflammation and swelling, and is mainly used to treat damp-cold and mucous respiratory diseases. It is used in Uighur medicine and folk for cold asthma, cough an...

Claims

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Application Information

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IPC IPC(8): A61K36/538A61P11/00A61P11/06
CPCA61K36/538A61K2236/333A61K2236/39A61K2236/55
Inventor 阿不都热依木·玉苏甫麦合苏木·艾克木
Owner XINJIANG MEDICAL UNIV
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