The invention discloses a preparation method of a pre-filled
dexmedetomidine hydrochloride injection. The preparation method of the pre-filled
dexmedetomidine hydrochloride injection comprises the following steps of: A, preparing 80% of prescribed
dose of water for injection, adding the prescribed
dose of
dexmedetomidine hydrochloride, stirring to dissolve for 5-8 minutes, then adding the water for injection to full
dose, carrying out
convection, and stirring and dissolving for 8-10 minutes; B, filtering a solution obtained by step A by virtue of a filter, and detecting an intermediate; and C, carrying out
nitrogen filling, prefilling, encapsulation and sterilization on a solution obtained by step B, thus the pre-filled
dexmedetomidine hydrochloride injection is obtained. The preparation method of the pre-filled
hydrochloric acid dexmedetomidine injection has the advantages that concept is skilful, operation is simple, the problem that the
dexmedetomidine hydrochloride injection is polluted in clinical application and inconvenient to use can be effectively solved, and
rapidity and safety of an operation process can be guaranteed.