The invention relates to the technical field of medicine analysis, and particularly provides a method of quickly analyzing illegal addition of a sildenafil analogue in yang-reinforcing health care products and a method of screening quick detection conditions for the sildenafil analogue. The method, through molecular docking, generally considers the intensity of interactions between a ligand (micro-molecules) and an acceptor (bio-macro-molecules), thereby finding compounds which have potential pharmacological activity and may be added as an illegal additive; furthermore, with combination of density functional theory, a theoretical Raman peak position is calculated, and theoretical shared peaks, which are obtained after data handling, are deeply developed; the results are used as an evidence for quickly determining illegally added sildenafil compounds in the health care products in on-site detection. The method is free of an artificially synthesized reference substance, has wide application range and low experiment cost, has simple operation, is quick, is suitable for on-site quick detection, and supplies stronger evidence to identification for the illegally added derivatives in the health care foods.