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108 results about "Copper nanoclusters" patented technology
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Double-fluorescence-emission copper nano-cluster/carbon dot colorimetric probe, preparation method and application in trace water detection
InactiveCN108489951AEasy to prepareShort timeFluorescence/phosphorescenceNanoclustersEnvironmental chemistry
The invention relates to an in-situ preparation method of a copper nano-cluster / carbon dot (Cu NCs / CDs) double-fluorescence-emission colorimetric probe based on AIEE, and application thereof in detecting trace water in an organic solvent, which belong to the technical field of colorimetric sensing. The method comprises three steps of synthesizing blue-fluorescence carbon dots (CDs), carrying out surface modification on the CDs, and preparing the double-fluorescence-emission Cu NCs / CDs probe. The double-fluorescence-emission probe Cu NCs / CDs obtained by the method shows a double-fluorescence-emission effect with 450nm blue light and 596nm red light in a visible region under the 365nm ultraviolet excitation. By utilizing different responses of double fluorescence on different water contentsin the organic solvent, different composite fluorescence color changes are displayed, so that double-fluorescence-emission test paper can be used for colorimetric detection on trace water in the organic solvent through naked eyes, the detection limit can be lowered to 0.02 percent (v / v), and convenience is provided for detecting the trace water in environmental protection, food safety and organicreaction.
Owner:JILIN UNIV
Method for preparing ratio fluorescence dopamine probe based on carbon spot/copper nanocluster compound
ActiveCN106970061AHigh selectivityIncreased sensitivityFluorescence/phosphorescenceLinear relationshipBovine serum albumin
The invention belongs to technical field of crossing of nano-materials and biochemical sensing, and relates to a method for preparing a ratio fluorescence dopamine probe based on a carbon spot / copper nanocluster compound. The method comprises the following steps: firstly, preparing carbon spots emitted by blue fluorescence to perform aminophenylboronic acid modification on the surface; then preparing bovine serum albumin-stabilized copper nanoclusters emitted by red fluorescence; mixing and reacting the carbon spots with the copper nanoclusters to prepare the carbon spot / copper nanocluster compound emitted by double fluorescence; then, adding dopamine to aqueous dispersion of the carbon spot / copper nanocluster compound; using a fluorescence spectrometer for measuring a fluorescence emission spectrum; fitting a linear relationship between ratio fluorescence peak intensity and dopamine coexistence concentration; and further, constructing the ratio fluorescence dopamine probe based on the carbon spot / copper nanocluster compound. The probe is simple in preparation process, low in preparation cost, high in sensitivity and selectivity, and capable of being developed into a novel ratio fluorescence probe applied to efficient detection of dopamine.
Owner:QINGDAO UNIV
Synthesis method for near-infrared fluorescent probe copper nano-cluster and application of synthesis method
InactiveCN104972135AGood water solubilityNo toxicityNanotechnologyBiological testingFluoProbesCell membrane
The invention discloses a synthesis method for a near-infrared fluorescent probe copper nano-cluster and a detection method for glycoprotein. The near-infrared fluorescent probe copper nano-cluster is synthesized through a one-pot method, aminophenylboronic acid is used for functionally transforming the synthesized copper nano-cluster, and the functionalized copper nano-cluster is obtained. Due to the specific action of boric acid groups on aminophenylboronic acid and cis diol in glycoprotein, the fluorescence intensity of the copper nano-cluster is quenched. A fluorescent probe can detect glycoprotein at high specificity and sensitivity. Glycoprotein widely exists in mucus, plasma, cytoplasm and cell membranes, is tightly related to living organisms, is an important physiological active material, and is tightly related to certain genetic diseases, and therefore important practical significance is provided for detecting glycoprotein.
Owner:TIANJIN NORMAL UNIVERSITY
Preparation method of quantum dot@Cu nano-cluster ratiometric fluorescent sensor and application thereof in Cu<2+> detection
InactiveCN104745194AFix interferenceHigh precisionFluorescence/phosphorescenceLuminescent compositionsFluoProbesFluorescent quenching
The invention discloses a preparation method of a quantum dot@Cu nano-cluster ratiometric fluorescent sensor and application thereof in Cu<2+> detection, belonging to the technical field of fluorescence sensing. According to the preparation method, CuNCs prepared by taking polyethyleneiminen as a template is coupled to the surface of silicon dioxide coated CdSe QDs to prepare CdSe QDs@CuNCs ratiometric fluorescent sensor having CdSe QDs and CuNCs double-fluorescence emission signals. When Cu<2+> exists in a solution, amino of polyethyleneimine and Cu<2+> are subjected to complexing to form a copper-amine complex, thereby avoiding the problem that CuNCs fluorescence quenching is caused but the fluorescence intensity of CdSe QDs is unchanged because electrons are transferred from amino to CuNCs. With the increase of Cu<2+> concentration, the intensity ratio of two fluorescence emission peaks of CdSe QDs and CuNCs is reduced gradually, thereby realizing sensitive fluorescent and visual detection on Cu<2+>.
Owner:NANCHANG UNIV
An electrochemical biosensor for detecting glutathione and a preparing method thereof
InactiveCN104267088ASensitive detectionQuick checkMaterial electrochemical variablesElectrochemical biosensorDouble strand
The invention relates to an electrochemical biosensor for detecting glutathione and a preparing method thereof. The biosensor is a three-electrode system sensor, wherein the counter electrode is a platinum electrode, the reference electrode is a saturated calomel electrode, and the working electrode is a gold electrode. The electrochemical biosensor and the method are characterized in that: the gold electrode is modified with double-stranded DNA capable of being adopted as a copper nanocluster synthesis template. According to the electrochemical biosensor and the preparing method, high-affinity bonding of the glutathione and a copper ion is utilized, synthesis of copper nanoclusters on surfaces of the electrodes is inhibited, and indirect detection of the glutathione is achieved by performing electrochemical quantitative characterization on the copper nanoclusters. The linear range of detection of the glutathione is 1-1000 nM, and the detection limit is about 0.42 nM. The electrochemical biosensor and the method have advantages of simple operation, low cost, using convenience, high selectivity, and the like, so that the electrochemical biosensor and the method have large potential application value in the fields of biochemical research, clinical analysis, and other fields.
Owner:SHANGHAI UNIV
Green synthetic method of fluorescence copper nano-cluster, and application of fluorescence copper nano-cluster
InactiveCN103820106AAvoid harmAvoid biotoxicityMaterial nanotechnologyFluorescence/phosphorescenceTumor targetTumor targeting
The invention discloses a green synthetic method of a fluorescence copper nano-cluster, and an application of the fluorescence copper nano-cluster. The synthetic method concretely comprises the following steps: incubating a certain concentration of a copper salt solution and different kinds of tumor cells, and carrying out in-situ synthesis to obtain a copper nano-cluster having an excellent fluorescence performance in order to realize the real time and high resolution fluorescence imaging of the tumor cells. The copper nano-cluster can realize the rapid real-time in-situ in-vivo tumor targeting fluorescence imaging on a tumor-hearing nude mouse model. The copper nano-cluster is prepared through direct biosynthesis of tumor cells and has a very good biocompatibility; and the method has the characteristics of environmental protection, no pollution to the environment, realization of rapid and accurate positioning and tumor targeting imaging analysis by the in-situ synthesis reaction, simplicity, easy implementation, accuracy and high efficiency.
Owner:SOUTHEAST UNIV
Method for preparing polymer protected fluorescent copper nanoclusters
ActiveCN104139188AImprove performanceLow priceNanotechnologyLuminescent compositionsPolymer solutionCupric nitrate
The invention discloses a method for preparing polymer protected fluorescent copper nanoclusters. The method is characterized by comprising the following steps of 1, dissolving a polymer solution and a 4-(2-hydroxyerhyl) piperazine-1-erhaesulfonic acid solution in a proper amount of pure water, and stirring to blend uniformly; 2, adding a cupric nitrate solution into the solution in the step 1, and continuously stirring; 3, adding a proper amount of methanol into the solution in the step 2 and heating at the temperature of between 50 and 90DEG C for 10 to 100 minutes to obtain a blue polymer protected fluorescent copper nanocluster solution. According to the method, a polymer is taken as a stabilizer, the methanol is taken as a reducing agent, 4-(2-hydroxyerhyl) piperazine-1-erhaesulfonic acid is taken as an auxiliary, cupric nitrate is taken as a Cu source, and reaction conditions are mild. The copper nanoclusters synthesized by the method have the advantages of low price, stable performance, no toxicity and the like, serve as a potential fluorescent label to be expectedly applied to the fields such as optical imaging, biomarkers and chemical sensors, and have wide application prospect in the fields such as environment analysis, biochemical analysis and food safety.
Owner:WUUHAN NUOWEIKAI BIOLOGICAL MATERIAL CO LTD +1
Preparation method and application of copper nano-cluster solution
InactiveCN105505382AStrong reductionGood water solubilityFluorescence/phosphorescenceLuminescent compositionsCopperDetection limit
The invention discloses a preparation method and an application of a copper nano-cluster solution. Polyethyleneimine is used as a template, and hydrazine hydrate is used as a reducing agent, so as to synthesize into a copper nano-cluster with stronger fluorescent property; the fluorescence of the material is quenched by trace Au (III) ions, and accordingly a new method for measuring the Au (III) ions is established. The preparation method has the advantages that the operation is simple, the detection limit is low, and the Au (III) can be quickly and accurately detected; the copper nano-cluster solution is used as a probe, the Au (III) is detected by fluorescence spectrophotometry, and a new concept is provided for the detection of Au (III).
Owner:ANHUI NORMAL UNIV
Preparation method of paracetamol ratio fluorescence sensor based on copper nanocluster/carbon dot/arginine compound
ActiveCN109164083AImprove anti-interference abilityEasy to operateOrganic active ingredientsNanomedicineInterference resistanceHydrogen
The invention specifically relates to a preparation method of a paracetamol ratio fluorescence sensor based on a copper nanocluster / carbon dot / arginine compound. The preparation method comprises the following steps: combining red fluorescent copper nanoclusters CuNCs with blue fluorescent carbon dots CDs by action of electrostatic adsorption and hydrogen bonds, and adding arginine to form a CuNCs / CDs / arginine compound, wherein blue fluorescence of CDs is weakened by adding arginine and then paracetamol is added, arginine and CDs are separated as the paracetamol is specifically combined with arginine, blue fluorescence of CDs is recovered and arginine and paracetamol do not cause remarkable change of fluorescence of CuNCs; responded to fluorescence of CDs, fitting a linear relationship between the fluorescent peak intensity ratio of CDs / CuNCs and concentration of paracetamol to establish the paracetamol ratio fluorescence sensor. Compared with the prior art, the method is simple to operate, high in interference resistance of ratio signals, good in accuracy and high in sensitivity and selectivity, and can be used as a novel ratio fluorescence sensor to detect paracetamol effectively.
Owner:QINGDAO UNIV
Fluorescence enhanced two-color visual narcotic detection probe and preparation method thereof
ActiveCN110609024AThe synthesis method is simpleRich sourcesMaterial nanotechnologyNanosensorsCopper nanoclustersMonoclonal antibody
The invention discloses a fluorescence enhanced two-color visual narcotic detection probe and a preparation method thereof. The fluorescence enhanced two-color visual narcotic detection probe is composed of a polydopamine nanosphere and two copper nanoclusters emitting fluorescent lights in different colors under the action of a single exciting light, and a methylamphetamine monoclonal antibody and a ketamine monoclonal antibody are respectively modified on the surfaces of the two copper nanoclusters. The detection probe disclosed by the invention is simple in preparation method, low in cost,easy to use, high in sensitivity and strong in reliability and can realize synchronous visual detection on multiple narcotics.
Owner:ANHUI UNIVERSITY
Copper nanoclusters synthesized by applying DNA nanoribbon template method, synthesis method and application of copper nanoclusters
ActiveCN110640158AOrderly rowsFluorescence intensity does not decayMaterial nanotechnologyMicrobiological testing/measurementBiologic AssaysDNA nanotechnology
The invention relates to the technical field of DNA nanotechnology, in particular to copper nanoclusters synthesized by applying a DNA nanoribbon template method, a synthesis method and application ofthe copper nanoclusters. According to the copper nanoclusters synthesized by applying the DNA nanoribbon template method, the synthesis method and the application of the copper nanoclusters, a DNA nanoribbon is synthesized by adopting a DNA origami technique, and the DNA nanoribbon is taken as a template to synthesize the copper nanoclusters; and the copper nano-clusters synthesized by applying the DNA nanoribbon template method are arranged more orderly, stable in fluorescence intensity, high in heat resistance, more excellent in performance, and are expected to show greater potential in theaspect of non-label fluorescence biological assay.
Owner:NORTHWEST UNIV
Preparation method of green fluorescent copper nanoclusters by one-step synthesis
InactiveCN109128217ASynthesis is simple and convenientShorten the timeNanotechnologyLuminescent compositionsCopper nanoclustersNanometre
The invention provides a preparation method of green fluorescent copper nanoclusters by one-step synthesis, aiming at the defects in the prior art. The fluorescent peak position of the synthesized copper nanoclusters synthesized by the method is about 530 nanometers, and the copper nanoclusters are definitely green fluorescent. Copper nanoclusters were synthesized by a "bottom-up" method using reduced copper ions directly and prepared by the one-step synthesis.
Owner:YUNNAN UNIV
Method for synthesizing blue fluorescent copper nanocluster by utilizing 6-mercapto-beta cyclodextrin
InactiveCN110079297AThe synthesis method is simpleLuminescent compositionsSynthesis methodsCopper nanoclusters
The invention discloses a method for synthesizing a blue fluorescent copper nanocluster by utilizing 6-mercapto-beta cyclodextrin, and belongs to the technical field of fluorescent copper nanoclusters. The method provided by the invention comprises the following steps: adding mono(6-mercapto-6-deoxy)-beta-cyclodextrin into copper sulfate under room temperature conditions, and reacting at a stirring rate of 500-600 rmp until the solution is colorless to obtain a solution A; adding a sodium hydroxide solution into the solution A to obtain a reaction system, and reacting at a stirring rate of 500-600 rmp until the reaction system is colorless to obtain a solution B; and placing the solution B at 55-85 DEGC and reacting for 60-270 min to obtain a dark brown solution, thereby obtaining the bluefluorescent copper nanocluster CuNCs@6-SH-CD. According to the method provided by the invention, the copper nanocluster is synthesized by utilizing mercapto-beta cyclodextrin as a reducing agent anda coating agent; and the synthesis method is simple.
Owner:YUNNAN UNIV
Fluorescent copper nanocluster and preparation method and application thereof
ActiveCN111687408AImprove stabilityEasy to operateTransportation and packagingMetal-working apparatusPyrrolidinonesPhotochemistry
The invention discloses a fluorescent copper nanocluster and a preparation method and application thereof, and belongs to the technical field of food detection. According to the fluorescent copper nanocluster, polyvinylpyrrolidone is used as a protective agent, copper salt is used as a metal precursor, 2-mercaptobenzothiazole is used as a stabilizer, ascorbic acid is used as a reducing agent, water-soluble orange fluorescent copper nanoclusters (CuNCs) with good stability are successfully prepared by a sonochemical reduction method, and the fluorescence intensity of the fluorescent copper nanoclusters has a good linear relationship with the ethanol concentration (5% to 90%); the fluorescent copper nanoclusters can detect the ethanol content in alcoholic drinks through the change of fluorescence intensity, and can be applied to the ethanol detection test paper to visualize the ethanol detection; and the preparation method has the advantages of environmental protection, time saving, sensitivity and non-toxic, and has a wide range of copper sources, and the application of the fluorescent copper nanoclusters to food safety detection is shown.
Owner:TAIYUAN NORMAL UNIV
Preparation of copper nanoclusters by using nucleosides as stabilizers and method using copper nanoclusters for identifying nucleosides
ActiveCN106978165AQuick identificationEasy to prepareNanotechnologyFluorescence/phosphorescenceSolubilityFluorescence spectra
The invention discloses preparation of copper nanoclusters by using nucleosides as stabilizers and a method using the copper nanoclusters for identifying the nucleosides, the preparation comprises the preparation of the copper nanoclusters by using three nucleosides (adenosine, cytidine and guanosine) as the stabilizers and use of a chemometric mode identification method for fast identifying the three nucleosides. The prepared nanoclusters stabilized by the nucleosides have good fluorescence properties, good water solubility, good light stability and biocompatibility and the like. The fluorescence spectra of the copper nanoclusters prepared based on the three nucleosides are different, by combination of the chemometric mode identification method, simultaneous identification of the three nucleosides can be achieved, and the identification method is accurate, rapid, sensitive and low in cost. The copper nanoclusters can also be used in the field of biosensing and cell imaging, and by combination of the chemometric mode identification method, the simultaneous identification of similar performance substances in the environment, food and medical fields can be achieved.
Owner:NANCHANG UNIV
Ratiometric fluorescent probe, and preparation method and application thereof
ActiveCN110591696AImprove accuracyIncrease credibilityFluorescence/phosphorescenceLuminescent compositionsCopper nanoclustersGraphene
The invention relates to a ratiometric fluorescent probe, and a preparation method and application thereof. According to the invention, firstly, a fluorescent probe layer taking fluorescent graphene oxide and copper nanoclusters as raw materials is prepared, and a probe carrier is printed or coated with the fluorescent probe layer to obtain the ratiometric fluorescent probe; the concentration value of an aniline drug sample can be obtained by detecting an RGB value of the aniline drug on the surface of the ratiometric fluorescent probe and substituting the RGB value into a standard curve. According to the invention, drug detection is based on a specific combination reaction of special amino groups of the aniline drug and surface carboxyl groups of the copper nanoclusters, and detection sensitivity and accuracy are high.
Owner:ANHUI UNIVERSITY
Preparation method and application of immunosensor constructed based on copper nanocluster-resonance energy transfer system
ActiveCN110530949AControl ECL StrengthHigh sensitivityBiological testingMaterial electrochemical variablesLuminous intensityBovine serum albumin
The invention discloses a preparation method and application of an immunosensor constructed based on copper nano-cluster-resonance energy transfer system, and belongs to the field of nano-material andresonance energy transfer FRET. According to the method, copper nanoclusters Cu NCs coated by bovine serum albumin (BSA) serve as an energy donor, and gold nanoparticles Au NPs are grown in situ on the surface of the Cu NCs by utilizing L-ascorbic acid to serve as an energy receptor, and a Cu NCs-Au NPs three-dimensional resonance structure is obtained. Energy is transmitted between the donor-receptor pair through a dipole-dipole non-radiation action mode; the transmission rate is inversely proportional to the six power of the distance; and ECL emission of the Cu NCs is remarkably quenched and the luminous intensity is controlled within a reasonable range by virtue of high-ratio overlapping of spectra and ultra-short pairing distance between the two. The invention provides a new ECL-FRETenergy transfer model for trace detection of biomarkers, and provides a brand-new thought for mechanism exploration of a quenching type ECL sensing system.
Owner:UNIV OF JINAN
Preparation method and application for green fluorescent copper nanoclusters
ActiveCN110125432AHigh sensitivityReduce pollutionTransportation and packagingMetal-working apparatusSolubilityBiocompatibility Testing
The invention provides a preparation method and application for fluorescent copper nanoclusters. The preparation method of the fluorescent copper nanoclusters comprises the following steps of uniformly mixing 1 part of a copper nitrate solution with the concentration being 0.05-0.2mol / L and 5-20 parts of a histidine aqueous solution with the concentration being 0.05-0.2mol / L at a room temperatureby volume parts, putting a mixture in a 300-700W microwave oven for heating for 10-20 min, and dissolving a reaction product with water to obtain a green fluorescent copper nanocluster aqueous solution. The preparation process disclosed by the invention is simple and rapid and has the advantages of cheap and available raw materials, excellent fluorescence performance, good biocompatibility and thelike; and the prepared copper nanocluster aqueous solution is good in water solubility and stability and high in fluorescence intensity, is non-toxic and can be applied to detection of pH sensing andpicric acid.
Owner:SHANXI UNIV
Ratio-type Ca<2+> fluorescent probe, and synthetic method and application thereof
InactiveCN107057689AHigh selectivityFix interferenceOrganic compound preparationAmino-carboxyl compound preparationAnti jammingCopper
The invention discloses a ratio-type Ca<2+> fluorescent probe and a synthetic method thereof, and belongs to the technical fields of fluorescent imaging and biosensing. The synthetic method comprises the following steps: synthesizing a novel Ca<2+> ligand having two aldehyde functional groups, and then modifying the Ca<2+> ligand, thus obtaining a template molecule; synthesizing fluorescent CuNCs (Copper Nano Clusters) on the basis that the template molecule is prepared, and then coupling with reference fluorescent molecules, thus constructing and obtaining the ratio-type Ca<2+> fluorescent probe in specific response with Ca<2+>. The ratio-type Ca<2+> fluorescent probe has two transmitting signals of the CuNCs and a reference probe, and is capable of correcting interference of environment and eliminating fluctuation of exciting light intensity. The invention also discloses the application of the ratio-type Ca<2+> fluorescent probe in cell imaging and biosensing. The synthetic method disclosed by the invention is simple and convenient, and the ratio-type Ca<2+> fluorescent probe prepared by the invention is high in selectivity and anti-jamming capability.
Owner:EAST CHINA NORMAL UNIV
Preparation method of imprinted electroluminescent sensor for enrofloxacin detection
ActiveCN111257397ALow costLarge specific surface areaMaterial nanotechnologyChemiluminescene/bioluminescenceElectrolytic agentEthylic acid
The invention provides a preparation method of an imprinted electroluminescent sensor for enrofloxacin detection. The electrochemical sensor is prepared on the basis of copper nanoclusters (CuNCs). Anacetic acid buffer solution containing enrofloxacin (ENRO) and o-phenylenediamine (OPD) is used as an electrolyte, a CuNCs / ENRO-OPD modified glassy carbon electrode is used as a working electrode, anAg / AgCl electrode is used as a reference electrode, and a platinum wire electrode is used as an auxiliary electrode to form a three-electrode system. A cyclic voltammetry is adopted, the polymerization potential is 0-0.8 V, and a CuNCs / ENRO-OPD thin film is obtained; eluting is performed with an eluent to obtain an enrofloxacin molecularly imprinted polymer film; and then electrochemical luminescence measurement is carried out, and then quantitative measurement of ENRO is performed. The method is utilized for detecting enrofloxacin and has the advantages of low detection limit, high sensitivity, good selectivity, good stability and the like and can realize detection of enrofloxacin in different animal husbandry samples under optimized experimental conditions.
Owner:YANTAI UNIV
Method for rapid synthesis of high fluorescence copper nanoclusters using polymer film as carrier
InactiveCN108971511AIncrease growth rateSave energyMaterial nanotechnologyTransportation and packagingNanoreactorCopper nitrate
The invention belongs to the technical field of preparation of luminescent nanometer materials and provides a method for rapid synthesis of high fluorescence copper nanoclusters using a polymer film as a carrier. The method includes 1), weighing a certain amount of chitosan, dropping glacial acetic acid to dissolve the chitosan completely, and configuring a chitosan solution with the mass percentage concentration of 1.5%-2.5%; 2), under room temperature, adding a glutathione solution and a cuprous nitrate trihydrate solution to the chitosan solution obtained in the step 1) and evenly stirringa mixed solution obtained, wherein the molar ratio of glutathione to copper nitrate trihydrate is 0.5:1-10:1; 3), allowing the mixed solution obtained in the step 2) to react for 5-7 hours in a blastbellow at the temperature of 35-45DEG C. With the method, the high fluorescence copper nanoclusters can be rapidly synthesized, the chitosan film serving as a good nanoreactor can protect the copper nanoclusters, energy loss from non-radiative transitions is reduced, and fluorescence strength is thereby improved.
Owner:DALIAN UNIV OF TECH
High-quantum-yield copper nanocluster fluorescent nanoflowers and preparation method and application thereof in LEDs
ActiveCN113025316AAchieve launchNovel structureSolid-state devicesSemiconductor/solid-state device manufacturingQuantum yieldLuminous intensity
Owner:SHANDONG UNIV
Heparin detection method for copper nano-cluster based on denatured bovine serum protein as template
InactiveCN108982432ASimple methodSynthetic method is simpleFluorescence/phosphorescencePhosphoric acidStandard curve
The invention discloses a heparin detection method for a copper nano-cluster based on a denatured bovine serum protein as template. The method comprises the following steps: forming a heparin detection system with a phosphoric acid buffer aqueous solution, a copper nano-cluster dispersion system and a to-be-tested sample; detecting fluorescence intensity change before and after adding the to-be-tested sample; and comparing with a standard curve to obtain the content of heparin in the to-be-tested sample. The method synthesizes the copper nano-cluster by taking the denatured bovine serum protein as the template by means of a one-pot method. The synthesized material is uniform in particle size, good in fluorescence property and stable in property, and the light-emitting position is near 642.04 nm and belongs to a near infrared area, so that interference of autofluorescence is avoided. The method can detect the heparin content directly and quickly, is wide in detection linear range and low in detection limit and has a very good application prospect in the fields of biological system detection, clinical applications and the like.
Owner:TIANJIN NORMAL UNIVERSITY
Method for synthesizing copper nano-clusters modified by silane in one step and application of copper nano-clusters modified by silane in detecting trace water-content in organic solvent
ActiveCN107363266ASpecial aggregation-induced luminescent propertiesLow toxicityMaterial nanotechnologyTransportation and packagingOrganic solventFluorescence
The invention discloses a method for synthesizing copper nano-clusters modified by silane in one step and application of the copper nano-clusters modified by the silane in detecting trace water-content in an organic solvent. The preparation method for the synthesizing copper nano-clusters modified by silane comprises the step that copper salt is placed in anhydrous acetonitrile, then the silane substituted by mercapto groups is added, stirring is conducted for 20-40 min under a sealed room-temperature condition, and the copper nano-clusters modified by the silane are obtained. Ultrasensitive detection of trace water in the organic solvent is achieved through the open pattern of a fluorescence signal. The method for synthesizing the copper nano-clusters modified by the silane in one step and the application of the copper nano-clusters modified by the silane in detecting the trace water-content in the organic solvent has the characteristics that the operating cost is low, preparation process equipment is simple, the reaction condition is gentle, the reaction speed is high, and popularization is easy.
Owner:ZHEJIANG NORMAL UNIVERSITY
Preparation method of polyvinylpyrrolidone-copper nanoclusters, product and application
InactiveCN111715890ANo aggregationHas fluorescent propertiesTransportation and packagingMetal-working apparatusCopper nanoclustersPyrrolidinones
The invention discloses a preparation method of polyvinylpyrrolidone-copper nanoclusters. The polyvinylpyrrolidone-copper nanoclusters are prepared from a copper ion solution, a protecting agent, a stabilizer and a reducing agent by a phonochemical reduction method. The preparation method of the polyvinylpyrrolidone-copper nanoclusters is convenient and environmental-friendly and the polyvinylpyrrolidone-copper nanoclusters are excellent in fluorescence characteristic and good in biocompatibility and double sensitive response to pH and temperature. The copper nanoclusters prepared by the method can be used as a fluorescent nano thermometer or a novel pH fluorescent test paper.
Owner:TAIYUAN NORMAL UNIV
High-fluorescence copper nanocluster-cerium (III) fluorescent probe as well as preparation method and application thereof
ActiveCN111521589AHigh selectivityAvoid interferenceFluorescence/phosphorescenceFluoProbesCopper nanoclusters
The invention discloses a high-fluorescence copper nanocluster-cerium (III) fluorescent probe as well as a preparation method and application thereof, and belongs to the technical field of fluorescence sensing. Based on the phenomenon that hydrogen peroxide can enable fluorescence of the copper nano-cluster-cerium (III) fluorescent probe to be subjected to linear quenching, the copper nano-cluster-cerium (III) fluorescent probe is used for constructing a hydrogen peroxide and glucose fluorescent sensor. The method for enhancing the fluorescence characteristic of the glutathione-stabilized copper nanocluster by adopting the metal cation cerium (III) is simple to operate and remarkable in fluorescence enhancement degree, has the characteristics of high response speed and wide linear range when being used for detecting hydrogen peroxide and glucose, and can realize visual detection of hydrogen peroxide and glucose.
Owner:WENZHOU MEDICAL UNIV
Integrated fluorescent test paper for detecting mercaptoacetic acid in real time and application
ActiveCN111157506AShort time spentThe synthesis method is simpleFluorescence/phosphorescenceCopper nanoclustersEngineering
The invention discloses integrated fluorescent test paper for detecting mercaptoacetic acid in real time and application. A filter paper strip is soaked in a 3.8 mM copper nano-cluster solution. The test paper can be used as fluorescent test paper for real-time, rapid and visual detection of sulfur-containing pollutant thioglycolic acid (TGA) in the environment. The test paper is prepared by uniformly infiltrating a filter paper strip with a certain shape into a copper nano-cluster solution synthesized by taking glutathione as a protective agent, drying and shaping. The copper nano-cluster fluorescent test paper has excellent fluorescent performance, fluorescence of the copper nano-cluster fluorescent test paper can be effectively quenched by mercaptoacetic acid, real-time rapid analysis and detection of mercaptoacetic acid in an actual environment sample can be realized, and the fluorescent test paper has extremely high application value and market prospect.
Owner:TIANJIN NORMAL UNIVERSITY
SARS-CoV-2 delta variant detection method based on primer design and copper nanoclusters
ActiveCN113913561AStrong specificityIncrease the number of AT basesMicrobiological testing/measurementAgainst vector-borne diseasesCopper nanoclustersEngineering
The invention discloses an SARS-CoV-2 delta variant detection method based on a primer design and copper nanoclusters. According to the method, a DPO primer and an AT primer are combined to successfully distinguish the SARS-CoV-2 delta variant with deletion of a single basic group from the SARS-CoV-2 wild strain. Moreover, PCR products of the DPO primer and the AT primer can be used as a generation template of the CuNCs, and visual detection of the SARS-CoV-2 delta variant is realized under ultraviolet irradiation. According to the method, the DPO primer and the AT primer are combined and amplified by virtue of a PCR instrument under conventional experimental conditions, so that the SARS-CoV-2 delta variant detection has the advantages of specificity, high sensitivity and visualization.
Owner:CHINA AGRI UNIV
Preparation method of graphene oxide fluorescence-enhanced functional nucleic acid hydrogel
ActiveCN112439370AImprove production efficiencyShort timeMicrobiological testing/measurementGel preparationCopper nanoclustersNucleic acid sequencing
The invention discloses a preparation method of graphene oxide fluorescence-enhanced functional nucleic acid hydrogel. According to the method, the efficiency of preparing the DNA hydrogel is improvedthrough a hyperbranched rolling cycle amplification (HRCA) technology, and meanwhile, a functional nucleic acid sequence is designed in a template sequence of an HRCA reaction, so a template capableof forming a fluorescent metal nano-cluster such as a copper nano-cluster (CuNCs) is provided for the prepared hydrogel; and moreover, a graphene oxide (GO) nanomaterial is introduced into a preparation system, so the influence of an HRCA reaction system on CuNCs fluorescence is reduced, and the fluorescence intensity of CuNCs is remarkably enhanced. By adding GO and forming CuNCs, the compactnessand viscoelasticity of a hydrogel network are improved, and meanwhile, a new morphology is provided for a microstructure based on nanoflowers. According to the invention, the GO fluorescence-enhancedfunctional nucleic acid hydrogel with enhanced fluorescence and strong universality is rapidly prepared, and has very good application prospects in the aspects of molecular detection, biological imaging and the like.
Owner:CHINA AGRI UNIV
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