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Method for preparing polymer protected fluorescent copper nanoclusters

A nanocluster and polymer technology, applied in nanotechnology, chemical instruments and methods, luminescent materials, etc., can solve the problems of less research on Cu nanoclusters, easy oxidation, large size of Cu nanoparticles, etc. Stable performance and mild reaction conditions

Active Publication Date: 2014-11-12
WUUHAN NUOWEIKAI BIOLOGICAL MATERIAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the current research on transition metal nanoclusters at the subnanometer scale mainly focuses on the noble metals Au and Ag, while relatively few studies on Cu nanoclusters in the same family (IB)
However, Cu nanoparticles obtained by traditional methods are larger in size and easier to oxidize.

Method used

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  • Method for preparing polymer protected fluorescent copper nanoclusters
  • Method for preparing polymer protected fluorescent copper nanoclusters

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A method for preparing polymer-protected fluorescent copper nanoclusters, comprising the steps of:

[0019] (1) Dissolve 500 μL of polyethyleneimine (PEI) solution with a concentration of 0.1 g / mL and 300 μL of 4-hydroxyethylpiperazineethanesulfonic acid (HEPES) solution with a concentration of 10 mmol / l in 2020 μL of pure water , stir for 5min;

[0020] (2) Add 150 μL of copper nitrate solution with a concentration of 100 mmol / l to the solution in step (1), and stir for 20 min;

[0021] (3) Add 30 μL of formaldehyde to the solution in step (2) under magnetic stirring, and heat at 50° C. for 20 min to obtain a blue solution, which is a polymer-protected fluorescent copper nanocluster. The electron microscope patterns of the polymer-protected fluorescent copper nanoclusters are as follows: figure 1 As shown, the fluorescence spectrum is as figure 2 shown.

Embodiment 2

[0023] A method for preparing polymer-protected fluorescent copper nanoclusters, comprising the steps of:

[0024] (1) 800 μL of chitosan solution with a concentration of 0.1 g / mL and 500 μL of 10 mmol / l 4-hydroxyethylpiperazineethanesulfonic acid (HEPES) solution were dissolved in 1390 μL of pure water and stirred for 20 min;

[0025] (2) Add 300 μL of 100 mmol / l copper nitrate solution to the solution in step (1), and stir for 5 min;

[0026] (3) Add 10 μL of formaldehyde to the solution in step (2) under magnetic stirring, and heat at 70° C. for 50 min to obtain a blue solution, which is a polymer-protected fluorescent copper nanocluster.

Embodiment 3

[0028] A method for preparing polymer-protected fluorescent copper nanoclusters, comprising the steps of:

[0029] (1) Dissolve 300 μL of lysine solution with a concentration of 0.1 g / mL and 600 μL of 4-hydroxyethylpiperazineethanesulfonic acid (HEPES) solution with a concentration of 10 mmol / l in 1980 μL of pure water, and stir for 10 min;

[0030] (2) Add 100 μL of copper nitrate solution with a concentration of 100 mmol / l to the solution in step (1), and stir for 15 min;

[0031] (3) Add 20 μL of formaldehyde to the solution in step (2) under magnetic stirring, and heat at 80° C. for 80 min to obtain a blue solution, which is a polymer-protected fluorescent copper nanocluster.

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Abstract

The invention discloses a method for preparing polymer protected fluorescent copper nanoclusters. The method is characterized by comprising the following steps of 1, dissolving a polymer solution and a 4-(2-hydroxyerhyl) piperazine-1-erhaesulfonic acid solution in a proper amount of pure water, and stirring to blend uniformly; 2, adding a cupric nitrate solution into the solution in the step 1, and continuously stirring; 3, adding a proper amount of methanol into the solution in the step 2 and heating at the temperature of between 50 and 90DEG C for 10 to 100 minutes to obtain a blue polymer protected fluorescent copper nanocluster solution. According to the method, a polymer is taken as a stabilizer, the methanol is taken as a reducing agent, 4-(2-hydroxyerhyl) piperazine-1-erhaesulfonic acid is taken as an auxiliary, cupric nitrate is taken as a Cu source, and reaction conditions are mild. The copper nanoclusters synthesized by the method have the advantages of low price, stable performance, no toxicity and the like, serve as a potential fluorescent label to be expectedly applied to the fields such as optical imaging, biomarkers and chemical sensors, and have wide application prospect in the fields such as environment analysis, biochemical analysis and food safety.

Description

technical field [0001] The invention belongs to the field of nanometer material preparation, and relates to a new method for preparing highly stable polymer-protected fluorescent copper nanoclusters. Background technique [0002] Clusters are relatively stable aggregates composed of several to thousands of atoms, molecules, and ions through physical and chemical binding forces, and their spatial dimensions range from several angstroms to hundreds of angstroms. Because nanoclusters have a large proportion of surface atoms, there are significant differences between the environment of this part of atoms and the atoms inside the cluster, making nanoclusters have a series of physical properties different from single atoms, molecules, and bulk solid materials. And chemical properties, such as the extremely high specific surface makes it have exceptionally high chemical activity and catalytic performance, the quantum size effect and nonlinear effect of light, the geometric size eff...

Claims

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Application Information

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IPC IPC(8): B22F9/24B82Y40/00C09K11/58C09K11/02
Inventor 宋功武王仁宗何瑜刘裕钟亚平葛伊利朱晶晶
Owner WUUHAN NUOWEIKAI BIOLOGICAL MATERIAL CO LTD
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