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Preparation method of polyvinylpyrrolidone-copper nanoclusters, product and application

A polyvinylpyrrolidone, copper nanotechnology, applied in nanotechnology, nano-optics, nanotechnology and other directions, can solve the problem of scarcity of bifunctional fluorescent copper nanoclusters, and achieve rapid reaction, short reaction time, and shortened reaction time. Effect

Inactive Publication Date: 2020-09-29
TAIYUAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, bifunctional fluorescent copper nanoclusters capable of detecting pH and temperature are still scarce.

Method used

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  • Preparation method of polyvinylpyrrolidone-copper nanoclusters, product and application
  • Preparation method of polyvinylpyrrolidone-copper nanoclusters, product and application
  • Preparation method of polyvinylpyrrolidone-copper nanoclusters, product and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Preparation of polyvinylpyrrolidone-copper nanoclusters

[0056] Pipette 2.0 mL of copper nitrate solution with a concentration of 1.0 mM, 4.0 mL of a solution of polyvinylpyrrolidone with a concentration of 0.069 mM, 6.0 mL of a solution of 2-mercaptobenzothiazole with a concentration of 0.1 mM, and 4.0 mL of a solution of ascorbic acid with a concentration of 0.1 mM Take it into a 25.0mL clean and dry glass reactor, mix it with ultrapure water at a constant volume, adjust the pH of the mixed solution to 10, place it in an ultrasonic cleaner with a power of 70W, and react at 10°C for 20min. The reaction solution was purified by dialysis with a 3500 dialysis bag to obtain a colorless aqueous solution of polyvinylpyrrolidone-copper nanocluster fluorescent probe, which was stored in a refrigerator at 4°C in the dark. The prepared fluorescent copper nanocluster solution is colorless under visible light, and produces strong orange fluorescence under 365nm ultraviolet light ...

Embodiment 2

[0058] Change the reaction conditions and the amount of raw materials for preparing copper nanoclusters, and judge the impact of the amount of PVP, MBT, VC, reaction temperature, time, power and pH on polyvinylpyrrolidone-copper nanoclusters (such as figure 2 Shown), and determine the optimal reaction conditions and dosage.

Embodiment 3

[0060] pH responsiveness test of polyvinylpyrrolidone-copper nanoclusters

[0061] Pipette 1.0mL of different pH (1.0-14.0) solutions into 2.0mL EP tubes, dilute to the mark with polyvinylpyrrolidone-copper nanoclusters; mL of EP tube diluted with ultrapure water to the mark as a control. Measure the fluorescence intensity of all solutions at excitation wavelength of 322nm and emission wavelength of 582nm.

[0062] image 3 It shows that the fluorescence intensity of polyvinylpyrrolidone-copper nanoclusters is quenched in different pH solutions, and its orange fluorescence gradually weakens under the irradiation of 365nm ultraviolet lamp. Depend on Figure 4 A shows that at different pH values, the fluorescence intensity of polyvinylpyrrolidone-copper nanoclusters at 580nm is gradually weakened or even quenched. Depend on Figure 4 B shows that in a neutral or alkaline environment, polyvinylpyrrolidone-copper nanoclusters have fluorescence intensity, and the fluorescence ...

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Abstract

The invention discloses a preparation method of polyvinylpyrrolidone-copper nanoclusters. The polyvinylpyrrolidone-copper nanoclusters are prepared from a copper ion solution, a protecting agent, a stabilizer and a reducing agent by a phonochemical reduction method. The preparation method of the polyvinylpyrrolidone-copper nanoclusters is convenient and environmental-friendly and the polyvinylpyrrolidone-copper nanoclusters are excellent in fluorescence characteristic and good in biocompatibility and double sensitive response to pH and temperature. The copper nanoclusters prepared by the method can be used as a fluorescent nano thermometer or a novel pH fluorescent test paper.

Description

technical field [0001] The invention relates to the field of analytical chemistry and fluorescent nanotechnology materials, in particular to a preparation method, product and application of polyvinylpyrrolidone-copper nano clusters. Background technique [0002] pH and temperature are important indicators commonly used in chemical and biological systems, affecting many chemical and biochemical reactions. In medicine, intracellular pH and temperature play a crucial role in many biological and physiological processes, such as enzyme activity, apoptosis, ion transport, phagocytosis, and other life activities such as tumor growth. Abnormalities in cell pH and temperature in mammals can lead to cellular dysfunction, leading to the occurrence of various diseases (including cancer and Alzheimer's disease, etc.). Therefore, accurate measurement of pH and temperature is crucial for environmental monitoring, clinical diagnosis, chemical reactions, and the development of cell biology ...

Claims

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Application Information

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IPC IPC(8): B22F9/24B22F1/00B82Y20/00B82Y40/00C09K11/02C09K11/58G01N21/64
CPCB22F9/24C09K11/58C09K11/025G01N21/6428B82Y40/00B82Y20/00G01N2021/6432B22F1/0545
Inventor 李林陈娟李媛张彩凤
Owner TAIYUAN NORMAL UNIV
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