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Preparation of copper nanoclusters by using nucleosides as stabilizers and method using copper nanoclusters for identifying nucleosides

A technology of copper nano-clusters and nucleosides, applied in the field of nano-materials, to achieve low cost, excellent fluorescent properties, and good stability

Active Publication Date: 2017-07-25
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the structures of different nucleosides are very similar, so their simultaneous identification is a very challenging task
Recently, it has been reported that chemometric pattern recognition methods can be used to easily and quickly distinguish substances with similar structures. However, the use of fluorescent copper nanoclusters to realize the identification of nucleosides has not been reported.

Method used

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  • Preparation of copper nanoclusters by using nucleosides as stabilizers and method using copper nanoclusters for identifying nucleosides
  • Preparation of copper nanoclusters by using nucleosides as stabilizers and method using copper nanoclusters for identifying nucleosides

Examples

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Effect test

Embodiment 1

[0025] A preparation method of copper nanoclusters:

[0026] (1) Weigh 210 mg of citric acid and dissolve it in 50 mL of twice-distilled water, and adjust the pH to 7 with 1 M NaOH.

[0027] (2) Take 400 µL of 1 mM Cu(NO 3 ) 2 , 1.8 mL of 10 mM adenosine, 1.5 mL of the buffer solution in step 1, 1.2 mL of 10 mM ascorbic acid, and finally add an appropriate amount of secondary water to make the total volume 10 mL, and mix well.

[0028] (3) The solution obtained in step (2) was left to react at 80 °C for 3 h to obtain adenosine-stabilized copper nanoclusters.

Embodiment 2

[0030] A preparation method of copper nanoclusters:

[0031] (1) Weigh 210 mg of citric acid and dissolve it in 50 mL of twice-distilled water, and adjust the pH to 7 with 1 M NaOH.

[0032] (2) Take 400 µL of 1 mM Cu(NO 3 ) 2 , 1.8 mL of 10 mM cytidine, 1.5 mL of the buffer solution in step 1, 1.2 mL of 10 mM ascorbic acid, and finally add an appropriate amount of secondary water to make the total volume 10 mL, and mix well.

[0033] (3) The solution obtained in step (2) was left to react at 80 °C for 3 h to obtain cytidine-stabilized copper nanoclusters.

Embodiment 3

[0035] (1) Weigh 210 mg of citric acid and dissolve it in 50 mL of twice-distilled water, and adjust the pH to 7 with 1 M NaOH.

[0036] (2) Take 400 µL of 1 mM Cu(NO 3 ) 2 , 1.8 mL of 10 mM guanosine, 1.5 mL of the buffer solution in step 1, 1.2 mL of 10 mM ascorbic acid, and finally add an appropriate amount of secondary water to make the total volume 10 mL, and mix well.

[0037] (3) The solution obtained in step (2) was left to react at 80 °C for 3 h to obtain guanosine-stabilized copper nanoclusters.

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Abstract

The invention discloses preparation of copper nanoclusters by using nucleosides as stabilizers and a method using the copper nanoclusters for identifying the nucleosides, the preparation comprises the preparation of the copper nanoclusters by using three nucleosides (adenosine, cytidine and guanosine) as the stabilizers and use of a chemometric mode identification method for fast identifying the three nucleosides. The prepared nanoclusters stabilized by the nucleosides have good fluorescence properties, good water solubility, good light stability and biocompatibility and the like. The fluorescence spectra of the copper nanoclusters prepared based on the three nucleosides are different, by combination of the chemometric mode identification method, simultaneous identification of the three nucleosides can be achieved, and the identification method is accurate, rapid, sensitive and low in cost. The copper nanoclusters can also be used in the field of biosensing and cell imaging, and by combination of the chemometric mode identification method, the simultaneous identification of similar performance substances in the environment, food and medical fields can be achieved.

Description

technical field [0001] The invention relates to a method for preparing copper nanoclusters with nucleosides as a stabilizer, and uses its fluorescence spectrum combined with a chemometric pattern recognition method to quickly identify different nucleosides, belonging to the technical field of nanomaterials. Background technique [0002] In recent years, metal nanoclusters such as gold, silver, platinum, and copper nanoclusters have attracted great interest due to their unique physical and chemical, optical, and electrical properties. Compared with organic dyes and traditional semiconductor quantum dots, metal nanoclusters have the advantages of good photostability, small particle size, low toxicity and good biocompatibility, so they have broader application prospects. Among them, copper nanoclusters, compared with gold, silver, and platinum, have the advantages of low cost, good fluorescence properties, low cytotoxicity, and good stability, so they are widely used in biosens...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/58G01N21/64B82Y40/00
CPCB82Y40/00C09K11/58G01N21/6402
Inventor 王勇陈天霞倪永年
Owner NANCHANG UNIV
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