86 results about "Ph sensing" patented technology

Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.

Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating of nanopores by: (1) self-assembly from solution, in which nanopores −10 nm diameter can be reproducibly coated, and (2) self-assembly under voltage-driven electrolyte flow, in which 5 nm nanopores may be coated. Applications of chemically modified nanopore are provided including: the detection of biopolymers such as DNA and RNA; immobilizing enzymes or other proteins for detection or for generating chemical gradients; and localized pH sensing.

Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiometric pH sensing, wherein the dye is further associated with a glucose binding moiety and configured to generate a signal that varies in intensity with the concentration of glucose.

A sensing device includes a substrate having a source region and a drain region formed therein. A gate structure is formed over the substrate and includes a gate dielectric and a gate conductor. The gate conductor is formed on the gate dielectric and disposed between the source region and the drain region. A dielectric layer is formed over the substrate and has a depth configured to form a well over the gate conductor. A gate extension is formed in contact with or as part of the gate conductor and including a conductive material covering one or more surfaces of the well.

Particular aspects provide novel devices and methods for accurately measuring total ammonia (NH3 plus NH4+) in a solution (e.g., freshwater and saltwater) by spatially proximate, simultaneous and continuous quantitative measurement of solution pH and ammonia. The devices overcome prior art inaccuracies relating to non-homogeneous sampling, and to spatial, temporal and thermal sampling discontinuities. Particular embodiments provide a combination pH and ammonia measuring device, comprising: a submersible member; a submersible non-bleeding ammonia-sensing portion attached to the submersible member and suitable to provide for a continuous visual indicator of solution ammonia concentration; a submersible non-bleeding pH-sensing portion attached to the submersible member and suitable to provide for a continuous visual indicator of solution pH; visual ammonia and pH indicator comparison means suitable for comparative quantitative determination of solution ammonia concentration and pH. Additional aspects provide novel ultra-sensitive devices and methods using same for measuring ammonia in air or solution.

Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating of nanopores by: (1) self-assembly from solution, in which nanopores −10 nm diameter can be reproducibly coated, and (2) self-assembly under voltage-driven electrolyte flow, in which 5 nm nanopores may be coated. Applications of chemically modified nanopore are provided including: the detection of biopolymers such as DNA and RNA; immobilizing enzymes or other proteins for detection or for generating chemical gradients; and localized pH sensing.

The invention discloses an efficient online measurement system of a biological membrane photobioreactor. The efficient online measurement system comprises a biological membrane photobioreactor system, a biomass concentration and biological membrane thickness sensing system, an FBG (Fiber Bragg Grating) temperature sensing system and a hydrogen concentration and PH (Potential of Hydrogen) sensing system, wherein the biological membrane photobioreactor system comprises a photobioreactor, a reactor light source, a peristaltic pump, a constant-temperature water bath, a culture medium liquid storage bottle, a gas collection bottle, a gas-liquid separation bottle and the like; the biomass concentration and biological membrane thickness sensing system comprises an optical fiber light source, a light filter, multi-mode optical fibers, an optical branching device, an optical coupler, a biomass concentration sensing probe, a biological membrane thickness sensor and the like; the hydrogen concentration and PH sensing system comprises an H2 electrode, a pH reference electrode, a pH electrode and the like. As the sensors for the online measurement of biomass concentration, pH and hydrogen concentration are adopted in the online measurement system, the biomass concentration and the pH in the reactor can be regulated according to the real-time measurement results of the sensors, and the regulated hydrogen producing speed of the biological membrane reactor is improved.

The invention discloses application of a near-infrared luminescent ruthenium complex to cell staining and pH sensing in a probe cell. The complex has almost no cytotoxicity at the staining concentration, and can stain a cell nucleus and cytoplasm. Through change of near-infrared luminescence intensity of the cell along with pH, the pH in the cell can be detected by a flow cytometry and a microscopic imaging technology.

The present invention relates to devices, methods, and kits for quickly and easily measuring and monitoring the pH of aquatic environments, such as lakes, streams, drinking waters, fisheries, aquariums, pools, hot-tubs, and spas. The current invention includes devices that are reusable and capable of monitoring the pH in a reversible fashion, thereby allowing continuous pH sensing without a need for the user to physically perform pH tests. Operation of the invention involves placing the device into the aquatic environment and optically detecting a color change in the membrane, for example, by looking at the device, when a pH measurement is desired. In addition, the device is both inexpensive and reusable, allowing the user to monitor the pH of various aquatic environment at minimal costs.

A pH sensing bioreaction system is provided. The system includes a bioreaction container (51) having a plastic wall (50) and a pH sensor (40, 60, 80, 100, 120) attached to the plastic wall (50). The pH sensor (40, 60, 80, 100, 120) includes a sensor body (82) having a flange (76) that is sealingly attached to the plastic wall (50). The sensor body (82) has a reference electrolyte (142) therein and a first sensing element (152) disposed in the reference electrolyte (142). The first sensing element (152) is configured to contact both the reference electrolyte (142) and a sample solution (52) inside the bioreaction container. A second sensing element (62, 92, 148) is positionable into an interior of the bioreaction container (51). The pH sensor (40, 60, 80, 100, 120) has a plurality of configurations that include a booted configuration in which at least one sensing element is isolated from the interior of the bioreaction container (51), and a service configuration in which the at least one sensing element is fluidically coupled to the interior of the bioreaction container (51).

The present invention discloses a field effect transistor structure-based pH sensing device and a manufacturing method thereof. The manufacturing method is as follows: firstly, a front gate oxide layer and a gate layer are deposited on the surface of a semiconductor layer of a semiconductor substrate on an insulating layer, a gate electrode structure is formed by etching of the front gate oxide layer and the gate layer; secondly, a source-drain structure is formed by doping of the semiconductor layer of the semiconductor substrate on the insulating layer on both sides of the gate electrode structure, and the gate electrode structure and the source-drain structure together form a field-effect transistor structure; and further, photolithography is performed on the back surface of a silicon substrate on the insulating layer, a supporting substrate and a buried oxide layer are etched until the lower surface of the semiconductor layer, and a back gate oxide layer is deposited on the lower surface of the etched semiconductor layer to complete the preparation of the pH sensing device. The method utilizes the contact between a solution to be tested and a back gate of the field-effect transistor to form a double-electric-layer structure on the surface of the back gate, by changing of the Zeta potential of the double-electric-layer on the surface of the back gate in different pH solutions, the threshold voltage of the field-effect transistor can be changed, the change of the resistance of the sensing device under a fixed bias voltage can be further led, the pH value of the solution can be tested.

The invention relates to a composition, method and apparatus for determining the sequence of a nucleic acid strand utilizing a pH-sensing agent.

Present invention describes a swallowable device with a soft, compliant exterior, whose shape can be changed through the use of magnetic fields, and which can be locomoted in a rolling motion through magnetic control from the exterior of the patient. The present invention could be used for a variety of medical applications inside the GI tract including but not limited to drug delivery, biopsy, heat cauterization, pH sensing, biochemical sensing, micro-surgery, and active imaging.

Described is a versatile surface modification approach to, for example, modularly and orthogonally functionalize nanoparticles (NPs) such as, for example, PEGylated nanoparticles, ith various types of different functional ligands (functional groups) on the NP surface. It enables the synthesis of, for example, penta-functional PEGylated nanoparticles integrating a variety of properties into a single NP, e.g., fluorescence detection, specific cell targeting, radioisotope chelating / labeling, ratiometric pH sensing, and drug delivery, while the overall NP size remains, for example, below 10 nm.

The invention provides a pH electrochemical sensor based on an aniline oligomer / graphene composite material. The sensor comprises a pH sensing electrode; the surface of the pH sensing electrode is modified by the aniline oligomer / graphene composite material; and the composite material is formed by coating the surface of the electrode with a composite material dispersion solution and then carryingout drying. The composite material modified electrode is simple in preparation process, small in size, low in production cost and convenient to detect, and does not need special treatment before and after being used; and the obtained pH electrochemical sensor can be used as a pH sensor to dynamically detect the change of the pH value, and can be applied to dynamic process detection of biological or chemical reactions. Graphene is introduced into aniline oligomer to obviously improve the pH sensitivity of the electrode; and meanwhile, compared with a pure aniline oligomer modified electrode, the detection sensitivity of the composite material modified electrode is improved by nearly three times from 2.60 [mu]A.pH-1.cm<-2> to 8.06 [mu]A.pH-1.cm<-2>, and the detection range is expanded from pH 1-9 to pH 1-13.

The invention provides a method for measuring a pH value of a sample solution, which is performed by a pH sensing device, including: providing a pH sensing device and a sample solution, wherein the pH sensing device includes a pH sensor array, and the pH sensor array comprises m pH sensors, and m is an integer greater than 1; measuring the sample solution with the pH sensor array for n times, wherein n is an integer greater than 1, n measurement values are generated, each pH sensor generates a measurement value for each measurement, and the total amount of measurement values generated is n×m; and generating a pH value of the sample solution by all of the measurement values generated by the pH sensor array.