40results about How to "Uniform crystal" patented technology

The invention discloses a preparation method of 18 alpha type diammonium glycyrrhizinate. Under a certain alkali concentration, 18 beta type diammonium glycyrrhizinate is converted into 18 alpha type diammonium glycyrrhizinate. The end point is judged according to a principle that under a certain chromatographic condition, the retention time of 18 beta type diammonium glycyrrhizinate and the retention time of 18 alpha type diammonium glycyrrhizinate are different, and high performance liquid chromatography (HPLC) is used to judge the end point. The obtained 18 alpha type diammonium glycyrrhizinate is added into stronger ammonia water, and after refinement, qualified diammonium salt can be obtained. Compared with the conventional technology, the reaction temperature is reduced by about 10 DEG C, the time is also shortened, thus the energy loss of industrial production can be largely reduced; at the same time, the service life of equipment is prolonged, and the cost is reduced. Furthermore, the high temperature of conventional technology will deepen the product color, and the post treatment becomes difficult. The prepared 18 alpha type diammonium glycyrrhizinate has the advantages of good color, high yield and high content. The preparation method is suitable for industrial massive production, the product color is good, the crystals are uniform, and the quality is good.

The invention discloses a riboflavin sodium phosphate compound. The riboflavin sodium phosphate is measured by using powder X-ray diffractometry, and characteristic diffraction peaks are displayed at positions of 11.87 degrees, 12.56 degrees, 13.90 degrees, 16.22 degrees, 16.98 degrees, 18.13 degrees, 19.02 degrees, 20.92 degrees, 21.54 degrees, 24.17 degrees, 24.89 degrees, 25.38 degrees, 26.78 degrees and 28.45 degrees in an X-ray powder diffraction pattern expressed by a 2theta diffraction angle. The invention also discloses a method for preparing the riboflavin sodium phosphate compound as well as freeze-dried powder injection, hydro-acupuncture or sterile powder injection prepared by utilizing the riboflavin sodium phosphate compound. The riboflavin sodium phosphate compound prepared by the invention has the advantages of stable property, oxidation difficulty and high water solubility.

The invention belongs to the field of medical intermediate preparation, and especially relates to a method used for purifying methyl 1, 2, 4-triazole-3-carboxylate coarse product. The wet methyl 1, 2, 4-triazole-3-carboxylate coarse product prepared by acylation, cyclization, esterification, diazotization and nitrogen-releasing suction filtration is used as a raw material. The method used for purifying the methyl 1, 2, 4-triazole-3-carboxylate coarse product comprises following steps: the wet coarse product is re-dissolved in methanol solvent; active carbon is added for decoloration; temperature reduction is controlled for recrystallization; and wet crystals obtained after recrystallization is dried so as to obtain finished products. The steps of the method are simple; the coarse product is re-dissolved, active carbon is used for adsorption, and temperature is controlled for recrystallization, so that the finished products with high purity and uniform crystals are obtained, and the finished products are of significant benefits on improvement of the quality of later produced medicine products, and are suitable for wide popularization and application.

The invention relates to a method for simultaneously extracting and separating glycyrrhizic acid and glycyrrhiza flavonoids of glycyrrhiza based on continuous chromatography and belongs to the field of natural medicine extraction. Radix glycyrrhizae is smashed and then undergoes extraction by ammonia and alcohol, continuous chromatographic adsorption, ethanol eluting 1, combined spin, polyamide adsorption, ethanol eluting 2 and rotary drying to obtain glycyrrhiza flavonoids; NaOH aqueous solution elution, pH adjustment, spin drying, filtering drying and recrystallization are performed to obtain glycyrrhizic acid. A production device adopted for the method is a continuous chromatographic separation system which is controlled under a logic control valve and is composed of 12 chromatographic columns, and the chromatographic column in the system is divided into four areas which are an adsorption area, a flavonoid analysis area, a glycyrrhizic acid analysis area and a resin regeneration area. The production process is simple to operate, the glycyrrhizic acid and glycyrrhiza flavonoids can be extracted simultaneously, waste of the glycyrrhiza flavonoids in conventional industrial production is reduced, the acid liquor pollution is avoided, so that the yield and purity of the obtained glycyrrhizic acid and glycyrrhiza flavonoids are high, and the method can be suitable for large-scale production.