Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of preparation method of L-carnitine tartrate

A technology of L-carnitine tartrate and L-carnitine, which is applied in the field of compound preparation, can solve problems such as affecting application, and achieves the effects of simple operation, high yield and good quality

Active Publication Date: 2021-04-27
NORTHEAST PHARMA GRP
View PDF13 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] It can be seen from the above synthetic route that the chemical synthesis of L-carnitine inevitably uses the key raw material trimethylamine, because trimethylamine has a serious fishy smell, resulting in the presence of synthesized L-carnitine and subsequent synthesized L-carnitine tartrate Severe fishy smell, which seriously affects its application in the fields of nutrition and health care, food additives and feed additives

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of L-carnitine tartrate
  • A kind of preparation method of L-carnitine tartrate
  • A kind of preparation method of L-carnitine tartrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Add 50.0g of L-carnitine and 300ml of methanol into a 500ml single-mouth bottle, stir to dissolve at 25°C, add 2.5g of deodorant, see Table 1 for the selection of the deodorant, stir for 1h, and suction filter, Obtain L-carnitine solution. The smell situation after the L-carnitine solution that obtains evaporates solvent is shown in Table 1:

[0024] Table 1: The deodorant effect of the selection of the deodorant on the product after the solvent is evaporated from the L-carnitine solution

[0025]

[0026] (2) Add L-carnitine solution and 10ml water to a 1000ml four-necked bottle equipped with a thermometer, heat up the system under stirring, maintain the body temperature at 58°C, add L-tartaric acid solution (prepared with 22.5gL-tartaric acid and 190ml methanol) dropwise, After the dropwise addition was completed in 45 minutes, the temperature was raised to 66° C., and the reaction was carried out for 2.5 hours. Cool down to 58°C, add 0.5g L-carnitine tartrat...

Embodiment 2

[0030] (1) Add 50.0g of L-carnitine and 300ml of organic solvent to a 500ml single-mouth bottle. The selection of the organic solvent is shown in Table 3. Stir to dissolve at 25°C, add 2.5g of activated carbon, stir for 1 hour, and suction filter to obtain L-carnitine solution.

[0031] (2) Add L-carnitine solution and 10ml water to a 1000ml four-necked bottle equipped with a thermometer, heat up under stirring, maintain the system temperature at 58°C, add dropwise L-tartaric acid solution (prepared by 22.5gL-tartaric acid and 190ml organic solvent, organic The selection of the solvent is shown in Table 3. After 45 minutes, the dropwise addition was completed, and the temperature was raised to 66° C., and the reaction was carried out for 2.5 hours. Cooling down to 58° C., adding 0.5 g of L-carnitine tartrate, stirring and crystallizing for 2.5 hours, cooling to 0° C., and stirring After crystallization for 4 hours, a large number of crystals were precipitated, filtered with su...

Embodiment 3

[0035] (1) Add 50.0 g of L-carnitine and 300 ml of methanol into a 500 ml single-necked bottle, stir to dissolve at 25° C., add 2.5 g of activated carbon, stir for 1 hour, and suction filter to obtain L-carnitine solution.

[0036](2) Add L-carnitine solution in a 1000ml four-necked bottle equipped with a thermometer, a certain amount of water, the selection of the amount of water is shown in Table 4, heat up under stirring, maintain the system temperature at 58°C, add dropwise L-tartaric acid solution ( 22.5g of L-tartaric acid and 190ml of methanol), the dropwise addition was completed in 45 minutes, the temperature was raised to 66°C, and the reaction was carried out for 2.5 hours. Cool down to 58°C, add 0.5g L-carnitine tartrate, stir and crystallize for 2.5 hours, cool down to 0°C, stir and crystallize for 4 hours, a large number of crystals precipitate, filter with suction, wash the filter cake with 100ml of methanol, and dry at 45°C for 7 Hour, get L-carnitine tartrate,...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A method for preparing L-carnitine tartrate applied in the field of compound preparation, the method can remove most of the fishy smell in L-carnitine products in the presence of anhydrous organic solvent and deodorant, And the process of preparing L-carnitine tartrate by forming salt with tartaric acid controls the reaction method and reaction conditions to obtain L-carnitine tartrate without fishy smell. Compared with the prior art, the obtained product has the advantages of good quality, no fishy smell, simple and convenient operation of the reaction process, high safety, suitable for industrial production, etc., and will be widely used in the field of preparation of L-carnitine tartrate.

Description

technical field [0001] The invention relates to a preparation method of L-carnitine tartrate without fishy smell in the field of compound preparation. Background technique [0002] L-carnitine (L-carnitine) is also called L-carnitine, white crystal or crystalline powder, highly hygroscopic, chemical name: (R)-3-hydroxy-4-trimethylammonium butyric acid, English name: ( R)-3-Hydroxy-4-(trimethylammonio)butyrate, molecular formula: C 7 h 15 NO 3 , molecular weight: 161.2, CAS: 541-15-1, the structural formula is as follows (formula Ⅰ): [0003] [0004] L-carnitine was discovered by Russian chemists Gulewitsch and Krimberg from meat extracts in 1905. It is an essential nutrient for humans and animals. Its basic function is to assist long-chain fatty acids to enter the mitochondria for oxidation. L-carnitine is widely used and can be used as clinical medicine for diseases such as chronic renal failure, coronary heart disease, and organic acidemia. Feed additives and othe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/18C07C229/22C07C51/41C07C51/43C07C59/255
CPCC07C51/412C07C51/43C07C227/18C07C229/22C07C59/255
Inventor 张卫军刘素娜李洋白洁王玉军韩晓丹王龙
Owner NORTHEAST PHARMA GRP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com