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Riboflavin sodium phosphate compound and preparation method thereof

A riboflavin sodium phosphate compound technology, applied in the field of highly stable riboflavin sodium phosphate compound and its preparation, can solve the problem of low stability of riboflavin

Active Publication Date: 2016-08-17
深圳朗欧医药集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Riboflavin injections and oral tablets are common clinically, but the stability of riboflavin is not high

Method used

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  • Riboflavin sodium phosphate compound and preparation method thereof

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Embodiment Construction

[0017] The present invention is described in further detail below in conjunction with embodiment.

[0018] The preparation method of the riboflavin sodium phosphate compound of the present embodiment may further comprise the steps:

[0019] (1) Add riboflavin sodium phosphate solid and carbon nanotubes into distilled water at 75-80°C, the mass ratio of the three substances is 1:2:50-100, after the riboflavin sodium phosphate solid is dissolved evenly, the solution Cool down to 1-10°C;

[0020] (2) Warm up the solution to 50°C, under ultrasonic waves with a frequency of 32-35KHz and an output power of 20-40W, add a mixed solution of absolute ethanol and anhydrous acetone 100 times the mass of riboflavin solid, and add as you go stir;

[0021] (3) After adding the mixed solvent, remove the ultrasonic wave, cool down to 15-20°C and let stand for 2-5 hours;

[0022] (4) Filtrate, wash with a 6:4 water:methanol solution, and dry to obtain the riboflavin sodium phosphate compound...

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PUM

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Abstract

The invention discloses a riboflavin sodium phosphate compound. The riboflavin sodium phosphate is measured by using powder X-ray diffractometry, and characteristic diffraction peaks are displayed at positions of 11.87 degrees, 12.56 degrees, 13.90 degrees, 16.22 degrees, 16.98 degrees, 18.13 degrees, 19.02 degrees, 20.92 degrees, 21.54 degrees, 24.17 degrees, 24.89 degrees, 25.38 degrees, 26.78 degrees and 28.45 degrees in an X-ray powder diffraction pattern expressed by a 2theta diffraction angle. The invention also discloses a method for preparing the riboflavin sodium phosphate compound as well as freeze-dried powder injection, hydro-acupuncture or sterile powder injection prepared by utilizing the riboflavin sodium phosphate compound. The riboflavin sodium phosphate compound prepared by the invention has the advantages of stable property, oxidation difficulty and high water solubility.

Description

technical field [0001] The invention relates to medicines, in particular to a highly stable riboflavin sodium phosphate compound and a preparation method thereof. Background technique [0002] Riboflavin sodium phosphate is a vitamin medicine. It is a part of the prosthetic group of yellow enzymes in the body (yellow enzyme plays a role of hydrogen delivery in biological redox). When it is lacking, it will affect the biological oxidation of the body and cause metabolic disorders. The lesions are mostly manifested in the mouth, eyes, and external genitalia. Inflammation of the site. Injections and oral tablets of riboflavin are common clinically, but the stability of riboflavin is not high. Contents of the invention [0003] In order to solve the above problems, the object of the present invention is to provide a highly stable riboflavin sodium phosphate compound. [0004] Realized by following technical measures, a kind of riboflavin sodium phosphate compound, described...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F9/6561
Inventor 邹翔
Owner 深圳朗欧医药集团有限公司
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