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Preparation method of L-carnitine tartrate

A technology of L-carnitine tartrate and L-carnitine, which is applied in the field of compound preparation, can solve problems affecting application, etc., and achieve the effects of simple operation, high yield, and uniform crystals

Active Publication Date: 2018-12-28
NORTHEAST PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] It can be seen from the above synthetic route that the chemical synthesis of L-carnitine inevitably uses the key raw material trimethylamine, because trimethylamine has a serious fishy smell, resulting in the presence of synthesized L-carnitine and subsequent synthesized L-carnitine tartrate Severe fishy smell, which seriously affects its application in the fields of nutrition and health care, food additives and feed additives

Method used

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  • Preparation method of L-carnitine tartrate
  • Preparation method of L-carnitine tartrate
  • Preparation method of L-carnitine tartrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Add 50.0g of L-carnitine and 300ml of methanol into a 500ml single-mouth bottle, stir to dissolve at 25°C, add 2.5g of deodorant, see Table 1 for the selection of the deodorant, stir for 1h, and suction filter, Obtain L-carnitine solution. The smell situation after the L-carnitine solution that obtains evaporates solvent is shown in Table 1:

[0024] Table 1: The deodorant effect of the selection of the deodorant on the product after the solvent is evaporated from the L-carnitine solution

[0025]

[0026] (2) Add L-carnitine solution and 10ml water to a 1000ml four-necked bottle equipped with a thermometer, heat up the system under stirring, maintain the body temperature at 58°C, add L-tartaric acid solution (prepared with 22.5gL-tartaric acid and 190ml methanol) dropwise, After the dropwise addition was completed in 45 minutes, the temperature was raised to 66° C., and the reaction was carried out for 2.5 hours. Cool down to 58°C, add 0.5g L-carnitine tartrat...

Embodiment 2

[0030] (1) Add 50.0g of L-carnitine and 300ml of organic solvent to a 500ml single-mouth bottle. The selection of the organic solvent is shown in Table 3. Stir to dissolve at 25°C, add 2.5g of activated carbon, stir for 1 hour, and suction filter to obtain L-carnitine solution.

[0031] (2) Add L-carnitine solution and 10ml water to a 1000ml four-necked bottle equipped with a thermometer, heat up under stirring, maintain the system temperature at 58°C, add dropwise L-tartaric acid solution (prepared by 22.5gL-tartaric acid and 190ml organic solvent, organic The selection of the solvent is shown in Table 3. After 45 minutes, the dropwise addition was completed, and the temperature was raised to 66° C., and the reaction was carried out for 2.5 hours. Cooling down to 58° C., adding 0.5 g of L-carnitine tartrate, stirring and crystallizing for 2.5 hours, cooling to 0° C., and stirring After crystallization for 4 hours, a large number of crystals were precipitated, filtered with su...

Embodiment 3

[0035] (1) Add 50.0 g of L-carnitine and 300 ml of methanol into a 500 ml single-necked bottle, stir to dissolve at 25° C., add 2.5 g of activated carbon, stir for 1 hour, and suction filter to obtain L-carnitine solution.

[0036](2) Add L-carnitine solution in a 1000ml four-necked bottle equipped with a thermometer, a certain amount of water, the selection of the amount of water is shown in Table 4, heat up under stirring, maintain the system temperature at 58°C, add dropwise L-tartaric acid solution ( 22.5g of L-tartaric acid and 190ml of methanol), the dropwise addition was completed in 45 minutes, the temperature was raised to 66°C, and the reaction was carried out for 2.5 hours. Cool down to 58°C, add 0.5g L-carnitine tartrate, stir and crystallize for 2.5 hours, cool down to 0°C, stir and crystallize for 4 hours, a large number of crystals precipitate, filter with suction, wash the filter cake with 100ml of methanol, and dry at 45°C for 7 Hour, get L-carnitine tartrate,...

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Abstract

The invention discloses a preparation method of L-carnitine tartrate in the field of compound preparation. According to the method, most fishy smell in an L-carnitine product can be removed in presence of an anhydrous organic solvent and a deodorant, the reaction method and the reaction condition are controlled in the process of preparation of L-carnitine tartrate through tartaric acid salifying,and the L-carnitine tartrate without the fishy smell is obtained. Compared with the prior art, the method has the advantages that the obtained product has good quality and no fishy smell, the reactionprocess is convenient to operate and high safety, the method is suitable for industrial production and the like and can be widely applied to the field of preparation of the L-carnitine tartrate.

Description

technical field [0001] The invention relates to a preparation method of L-carnitine tartrate without fishy smell in the field of compound preparation. Background technique [0002] L-carnitine (L-carnitine) is also called L-carnitine, white crystal or crystalline powder, highly hygroscopic, chemical name: (R)-3-hydroxy-4-trimethylammonium butyric acid, English name: ( R)-3-Hydroxy-4-(trimethylammonio)butyrate, molecular formula: C 7 h 15 NO 3 , molecular weight: 161.2, CAS: 541-15-1, the structural formula is as follows (formula Ⅰ): [0003] [0004] L-carnitine was discovered by Russian chemists Gulewitsch and Krimberg from meat extracts in 1905. It is an essential nutrient for humans and animals. Its basic function is to assist long-chain fatty acids to enter the mitochondria for oxidation. L-carnitine is widely used and can be used as clinical medicine for diseases such as chronic renal failure, coronary heart disease, and organic acidemia. Feed additives and othe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/18C07C229/22C07C51/41C07C51/43C07C59/255
CPCC07C51/412C07C51/43C07C227/18C07C229/22C07C59/255
Inventor 张卫军刘素娜李洋白洁王玉军韩晓丹王龙
Owner NORTHEAST PHARMA GRP
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