Preparation method of acetylisovaleryltylosin tartrate
A technology for acetylisovaleryl tylosin tartrate and acetylisovaleryl tylosin is applied in the field of preparation of acetylisovaleryl tylosin tartrate, and can solve the problems of high operation toxicity, difficulty in filtration, environmental pollution and the like , to avoid environmental pollution problems, reduce the introduction of impurities, and improve the extraction yield.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0035] The titer of the acetylisovaleryl tylosin fermentation broth is 16479μ / ml, and the volume of the fermentation broth is 5m 3 .
[0036] Acidify the acetylisovaleryl tylosin fermentation broth, adjust the pH to 1.1 with oxalic acid and let it stand for 20 minutes, then continue to adjust the pH to 4.5 with 10% liquid alkali and let it stand for 20 minutes.
[0037] The acetylisovaleryl tylosin fermentation broth was heated up to 40°C, and plate and frame filtration was performed, and the material of the filter cloth was polyester. Filtration ends, obtain filtrate 4.6m 3 , the titer was 17249μ / ml, and the yield of pretreatment was 96.3%.
[0038] Dilute acetylisovaleryl tylosin fermentation broth to 14m with drinking water 3 .
[0039] At 40°C, a mixture of 14kg of activated carbon and 280kg of potassium chloride was added, and the stirring and standing time were controlled at 20min, respectively. Carry out solid-liquid separation after decolorization, obtain filtrate...
Embodiment 2
[0047] The titer of the acetylisovaleryl tylosin fermentation broth is 15637μ / ml, and the volume of the fermentation broth is 5m 3 .
[0048] Acidify the acetylisovaleryl tylosin fermentation broth, adjust the pH to 1.2 with oxalic acid and let it stand for 23 minutes, then continue to adjust the pH to 4.7 with 12% liquid alkali and let it stand for 23 minutes.
[0049] The acetylisovaleryl tylosin filtrate was warmed up to 42°C, and subjected to plate and frame filtration, and the material of the filter cloth was polypropylene fiber. Filtration ends, obtain filtrate 4.6m 3 , the titer was 16385μ / ml, and the yield of pretreatment was 96.4%.
[0050]Dilute acetylisovaleryl tylosin filtrate to 16.1m with drinking water 3 .
[0051] At 42°C, a mixture of 24kg of diatomaceous earth and 400kg of sodium chloride was added, and the stirring and standing time were respectively controlled at 22min. Carry out solid-liquid separation after decolorization, obtain filtrate 16m 3 , th...
Embodiment 3
[0059] The titer of the acetylisovaleryl tylosin fermentation broth is 15862μ / ml, and the volume of the fermentation broth is 5m 3 .
[0060] Acidify the acetylisovaleryl tylosin fermentation broth, adjust the pH to 1.3 with oxalic acid and let it stand for 25 minutes, then continue to adjust the pH to 5 with 13% liquid alkali and let it stand for 25 minutes.
[0061] The acetylisovaleryl tylosin fermentation broth was heated up to 45°C, and plate-and-frame filtration was performed, and the material of the filter cloth was polyester. Filtration ends, obtain filtrate 4.6m 3 , the titer was 16707μ / ml, and the yield of pretreatment was 96.9%.
[0062] Dilute acetylisovaleryl tylosin filtrate to 18.4m with drinking water 3 .
[0063] At 45°C, a mixture of 31.6kg of activated carbon and 552kg of potassium chloride was added, and the stirring and standing time were respectively controlled at 25min. After decolorization, solid-liquid separation was carried out to obtain a filtra...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com