563results about How to "The dosage is easy to control" patented technology

The invention relates to extraction of an active ingredient exosome from a human umbilical cordmesenchymal stem cell and application thereof in preparation of medicaments for treating liver and kidney injury and skin diseases. The human umbilical cordmesenchymal stem cell-derived exosome is prepared by the following steps of: (1) culturing a human umbilical cordmesenchymal stem cell; (2) preparing a cordmesenchymal stem cell conditioned medium; and (3) separating and purifying the exosome. The experiments for infusing the human umbilical cordmesenchymal stem cell exosome serving as a medicament into a mice acute liver injury model, a rat kidney injury model and a rat skin scald model show that the medicament can improve the liver function, the kidney function and the skin condition, promote the pathological recovery of the liver, the kidney and the skin, reduce the death rate, fulfill the aims of blocking and reversing the development of the liver and kidney injury and open up a new approach for clinical treating of the liver and kidney injury.

The invention relates to a traditional Chinese medicine white wine medicament for effectively curing dermatopathy, which has the advantages of reasonable and scientific composing prescriptions, evident effect, convenient and hygienic employment, and is natural without hormones and chemical auxiliary agent, and is safe and reliable, and does not have side effect. The invention is made from raw material with the following part by weight, anoelica sinensis 8-10 parts by weight ( the following unit is the same), red peony root 6-10, chuanxiong rhizome 3-5, schizonepeta tenuifolia 3-5, coralbean bark 6, astragalus root 6-8, Chinese dittany bark 10-15, phillyrin 12-15, flavescent sophora root 15, honeysuckle flower 8-12, borneo camphor 3-5, radix salvia miltiorrhiza 9, frank incense 5, myrrh 5, and white wine 1.5-2, and the following operating procedures are concluded, the raw material except the borneo camphor, the frank incense, and the myrrh are positioned in a vessel and are filled with the white wine with the amount of 3-5cm higher than the medicine surface, and are sealed, and are opened and churned once a weak, and are immersed for three months in spring and two months in summer, and are filled with the frank incense and the myrrh one week before the employment, and can be employed when the medicine is filtered and is added with the borneo camphor.

The invention discloses a method for improving the uniformity of axial resistivity of czochralski silicon. The method comprises the steps as follows: (1) melting a polycrystalline silicon raw material and a solid doping agent in an argon atmosphere to obtain stable molten silicon; (2) introducing seed crystals into the stable molten silicon, and conducting constant diameter growth on the crystals after necking and shouldering processes; and (3) during the constant diameter growth period, adding dopant gas with the conductive type opposite to that of the solid doping agent until the growth of the czochralski silicon is fulfilled. According to the method, the type and the usage amount of the dopant gas are convenient to control, various required impurity concentration distributions can be obtained, the utilization rate of the czochralski silicon is increased, and the uniformity of the resistivity of the czochralski silicon is remarkably improved.

The present invention discloses a protease super-concentrated laundry detergent, which mainly comprises, by mass, 3-38% of a non-ionic surfactant, 1-22% of an anionic surfactant, 0.1-1% of protease, 0.1-2% of triethanolamine, 0.1-2% of sodium citrate, 0.1-2% of refined salt and 60-70% of deionized water, wherein the protease comprises biological protease and compound protease. According to the present invention, the protease super-concentrated laundry detergent product is neutral and has characteristics of mild nature, no stimulation, soft hand-feeling, no alkaline residue after washing, no skin allergy and other symptoms, no damage on fabrics, water solubility, easy use, easy use amount control, easy storage, and easy use; and the process operation of the preparation method is simple, and the method is easily subjected to industrial production.

The invention provides an internet-based intelligent kitchen terminal product and a configuration method thereof. The product is characterized in that any one or more than one types of the following combinations from 1-1 to 1-5 and any one or more than one types of the following combinations from 1-6 to 1-9 are arranged on a terminal displayer; and the combinations from 1-1 to 1-5 include a display device used for guiding users to perform kitchen operation; built-in intelligent kitchen terminal application programs which are equipped with multiple input and output interfaces; multiple types of built-in wireless connecting modules; a processor; a memory; a power supply; a terminal display interface; and system programs. The combinations from 1-6 to 1-9 include multiple configured installing modes; and an intelligent kitchen terminal with an LED or liquid crystal display screen (LCD) for display, wherein the intelligent kitchen terminal includes any one of a square interface, a rectangular interface, a circular interface and an elliptical interface, and the boundary dimension has the appropriate size of length*width and at least covers or belongs to the range of 5.0-50cm*5.0-50cm.

The invention relates to a preparation method of nano hydroxylapatite doped with metal ions, which comprises the following steps of: firstly, respectively preparing Ca(NO3)2 and (NH4)2HPO4 solution, mixing the Ca(NO3)2 and (NH4)2HPO4 solution, and obtaining clear and transparent solution A; adding metal nitrate into solution A and obtaining clear and transparent solution B; adding CO(NH2)2 into solution B, and obtaining solution C; finally heating and backflowing the solution C for 3 to 5 hours with the temperature of 100 DEG C under the magnetic force stirring; after the reaction is end, naturally cooling to room temperature; then vacuum-filtering, cleaning with water, drying for 24 hours under the temperature of 100 DEG C; and finally, obtaining nano hydroxylapatite crystal doped with metal ions. The preparation method adopts a metal salt solution heating even precipitation method, and takes inorganic salts containing calcium and phosphate group as raw materials; urea is acidity of a control reaction system of an additive; metal salts are added according to the doped proportion of 1 percent to 5 percent; reaction is carried out under the magnetic force stirring and heating conditions; and the backflowing of reaction liquid is adopted to synthesize nanoscale metal-doped nano hydroxylapatite crystal by one step. The method is obviously characterized by even doping and easy control for added amount.

The invention relates to an ambroxol hydrochloride freeze-dried powder injection and a preparation method thereof. The freeze-dried powder injection comprises ambroxol hydrochloride and mannitol. The ambroxol hydrochloride freeze-dried powder injection prepared by a freeze-drying technology has good stability and high dissolution velocity while all other indexes accord with regulation.

The invention discloses a rapid diluting and mixing device for an agricultural agent. The rapid diluting and mixing device comprises a shell, a motor, a medicine kit and a base, wherein a horizontal rotating disk is fixed at the lower end of a transmission shaft; a vertical first stirring shaft is fixedly inserted into a first bearing; a plurality of horizontal stirring rods are fixed on the side wall of the first stirring shaft; a driven gear is meshed with a horizontal driving gear; a mixing blade is fixed at the lower end of a second stirring shaft; vertical connection openings are formed in a seal ring and a seal plate; a mobile regulating mechanism comprises a slide chute, a support rod, a mobile wheel, a threaded tube, a screw rod and a handle. The mixing blade and the stirring rods are driven to rotate simultaneously through the arranged turn plate, and internal different positions are stirred, so that the mixing effect of a liquid medicine is improved and the uniform mixing of the liquid medicine is ensured; and the liquid medicine in the medicine kit falls off through the rotating connection openings, the agent discontinuously falls off and the agent can be quickly mixed with water, so that the mixing efficiency is improved.

This invention relates to the insect protected textile making method, the character is that it uses dip-dyed or roll-dyed to dye the Pyrethrum Ester onto the synthetic fiber textile or yarn, wherein the synthetic fiber includes the composite silk, single silk, stable fiber textile and natural fiber blended or interlaced textile of the polyester, polyamide, polyurethane, polypropene, polyethene, polyacrylonitrile, polyvinyl chloride, the yarn is the related composite silk, single silk, stable fiber textile and natural fiber blended or interlaced yarn; the Pyrethrum Ester is hydrophobic, its molecular weight is less than 700, the decompose temperate is higher than that is dip-dyed or roll-dyed, and it has at least one group of the -OH,-CN, -NH2,-NHR,-NR2,-NHCOR,-I,-CI,-Br,-NO2,-SONH2. The advantage of this invention is that the production flow is short, the operation is simple; and the dosage is controlled.

The invention discloses a water-swelling rubber composite material. The rubber composite material is formed from the following components in parts by weight: 100 parts of rubber, 30-100 parts of super adsorbent resin, 2-10 parts of metal ion sealing agent, 0.5-2.5 parts of solid softening agent, 0.5-3.5 parts of coloring agent, 1-7 parts of anti-aging agent, 1-7 parts of accelerant, 1-8 parts of zinc oxide, 5-45 parts of reinforcing agent, 5-20 parts of plasticizer, 0.1-2.6 parts of vulcanizing agent, and 5-45 parts of mixture of PEG (polyethylene glycol) and MDI (diphenylmethane diisocyanate) at a molar ratio of 1:1. The invention further provides a preparation of the rubber composite material, in particular provides an application of the rubber composite material as superfine rubber swelling particles in a large pore path or high-permeability belt of a reservoir deep strata for profile control and water shutoff of an oil-water well.

The invention discloses a preparation method of a photocatalyst based on monodisperse elemental bismuth and carbon nitride. The method comprises the following key steps: monodisperse elemental bismuth particles which are prepared through a liquid phase chemical reduction technology are immobilized on the surface of carbon nitride used as a carrier and prepared by using urea as a precursor, and a surfactant component in the above obtained composite system is removed through a coordination exchange reaction to obtain the elemental bismuth / carbon nitride photocatalyst. The preparation method of the elemental bismuth / carbon nitride photocatalyst has the advantages of simple process, low energy consumption, controllable material morphology and high reaction activity. The elemental bismuth / carbon nitride photocatalyst prepared in the invention can rapidly and effectively remove carbon monoxide and other pollutants in air, and the catalysis activity can be regulated through the controllable synthesis of the elemental bismuth.

The invention belongs to the technical field of biological medicine, and particularly relates to a three-function molecule combining CD19, CD3 and CD28 and application of the three-function molecule. The three-function molecule capable of identifying CD19, CD3 and CD28 simultaneously is constructed through a genetic engineering method and an antibody engineering method. In the aspects of a preparation technology and practical application, the molecule has the obvious advantages that the effect of activated T cells is further improved while the targeting property on CD19 positive cells is given to the T cells; when only CD19 is added, the bonding and killing effects of the CD19-mediated T cells on CD19 positive target cells are superior to those of an anti-CD19 / anti-CD3 BiTE bispecific antibody, and the using convenience is superior to that of a CD19-targetted CAR-T technology.

The invention discloses a method for preparing dapoxetine hydrochloride. The method comprises the following steps: subjecting (s)-3-amino-3-phenylpropionic acid or an ester thereof to a reduction reaction in a reduction system prepared from a hydroborate and a boron trifluoride complex, so as to obtain an intermediate 1, i.e. (s)-3-amino-3-phenylpropanol; subjecting the (s) intermediate 1 to an Eschweiler-Clark reaction with formic acid and formaldehyde, so as to obtain an intermediate 2; subjecting the intermediate 2 to a Williamson ether forming reaction with 1-fluoronaphthalene, so as to obtain a free alkali, i.e. (s)-N,N-dimethyl-3-(1-naphthyloxy)phenyl propyl amine; subjecting the free alkali to a salt forming reaction with alcohol-acyl chloride or a chloride thereof, a hydrochloric acid organic solution or hydrochloric acid gas, thereby obtaining dapoxetine hydrochloride. According to the method, the synthesis route is low in production cost, the reaction conditions are mild, all the materials are readily available, the raw materials are low in toxicity, the reaction is simple in operation and high in safety, and the product is high in purity and yield and is environmentally friendly, so that the method is applicable to industrial large-scale production.

The invention discloses to a drug compound for treating diabetes and particularly relates to a drug compound oral pharmaceutical formulation adopting pioglitazone as the ingredient. The drug compound aims to supplement the deficiency of the prior oral pharmaceutical formulation used for treating Type-2 Diabetes and provide a drug compound oral pharmaceutical formulation, sustained-release pioglitazone dropping pill which has high bioavailability, controllable release time, long-acting effect, low frequency of drug taking, steady plasma concentration, low cost and absence of contamination during the production. The sustained-release pioglitazone dropping pill adopts pioglitazone as the chemical ingredient and is prepared jointly with the medicinal carriers of hydrophilic frame ingredients and hydrophobic frame ingredients used as the stroma.

A Chinese medicine in the form of dripping pill for treating cold, fever, sore throat, etc is prepared from scutellaria root, forsythia fruit, isatis leaf and liquorice root.

The invention belongs to the technical field of plant growth regulators, and relates to a medicament composition being capable of controlling flourishing of plants and having a production increasing effect and application of the medicament composition. A plant growth regulator composition provided by the invention comprises the active ingredients of prohexadione calcium, paclobutrazol and a plant growth promoter, wherein the plant growth promoter is compound sodium nitrophenolate, diethyl aminoethyl hexanoate or gibberellin. 25% prohexadione calcium and paclobutrazol composite medicament wettable powder is used for controlling the flourishing of crops, and has the best effect when the dosage is 20g / acreage when being particularly used for controlling the flourishing of peanuts, soybeans or rapes. The plant growth regulator composition disclosed by the invention belongs to a ternary complex product, and compared with singly using prohexadione calcium to adjust the growth of the crops, the cost is greatly reduced, the dosage is easy to control, and the production increase of the crops is obvious; the safety is much higher than that of singly using paclobutrazol; compared with other triazole plant growth regulators for retarding plant growth, the plant growth regulator composition has the advantages of low residual toxicity, less dosage and environmental friendliness.

The invention provides a radioactive particle chain. The radioactive particle chain includes a soft tube having good histocompatibility and equivalent effects of radiotherapy tissue; one end of the soft tube is closed, and the other end of the soft tube is movably connected to a baffle sheet, wherein the area of the baffle sheet is greater than a cross sectional area of the soft tube; and radioactive particles are arranged in the soft tube. The radioactive particle chain can determine initial treatment dose through the characters of a tumor; periodic review is performed after the radioactive particles are arranged in the tumor; when the size of the tumor changes, the number of the radioactive particles can be increased or decreased by inserting or pulling out the radioactive particles, and then the dose of the radioactive particles can be controlled conveniently after the radioactive particles are implanted into the tumor; all the radioactive particles can be taken out when the tumor vanishes or a patient dies; and the complication can be reduced, and radiation to the patient or public can be decreased. The radioactive particles used in the patient can be disinfected and reused in tumors in other parts of the same patient after being taken out, and then medical resources can be saved, and the patient can accept the radioactive particles in mind.

The invention provides injection fleroxacin which is composed of fleroxacin, mannite and lactic acid; the invention also provides a preparation method of the fleroxacin freeze-dried powder: fleroxacin and mannite are added into water, then lactic acid is also dropped into the water, and the solution is stirred until the fleroxacin is dissolved completely; active carbon is added into the mixed solution which then is filtered; the filtrate is placed in a material disc of a freezedryer to be cooled slowly to 30DEG below zero to 60DEG below zero and be kept the prelimitary freezing for 2.5 to 3 hours at 30DEG below zero to 60DEG below zero, then is rapidly cooled to about 45DEG below zero to 55DEG below zero to be pumped to vacuum, is heated to 5DEG below zero to 5DEG for 12 to 15 hours and is kept at 5DEG below zero to 5DEG for 4 to 6 hours, is heated to 25DEG to 30DEG within 3 to 5 hours and is kept at 25DEG to 30DEG for 5 to 7 hours so that the fleroxacin freeze-dried powder is obtained. The obtained fleroxacin freeze-dried powder has simple components, favorable stability and resolubity and low water content.

The invention discloses a hyperconcentration clear water type laundry sheet, belonging to daily washing articles. The preparation raw materials at least include a detergent, polyvinyl alcohol, glycerin, silicone oil and water, wherein the detergent is formed by two anionic surfactants, two nonionic surfactants or an anionic surfactant and a nonionic surfactant; and moreover, the raw materials also can include pigment, fragrance, EDTA disodium and sodium citrate. The preparation comprises the following steps: putting the polyvinyl alcohol, pigment and partial water into an emulsifying pot and stirring uniformly; adding the detergent, glycerin, silicone oil, fragrance, EDTA disodium and the rest water, and stirring uniformly; adding the sodium citrate and stirring again; discharging; drying the material body in a dryer and removing out of the cylinder; slicing, sealing and packaging; and subpackaging and storing to finish the preparation. The laundry sheet has the characteristics of convenience in carrying, easiness in use, easiness in dosage control, easiness in dissolution without residue, environment friendliness and no waste; and moreover, the preparation steps are simple, the production cost can be greatly reduced, and the production efficiency is improved.

The present invention discloses a medicine composition-Shanlucha dripping pill oral preparation with the effects of clearing away heat and toxic material, calming the liver and subduing liver-yang for curing the diseases of vertigo, tinnitus, headache, feeling of fullness in the head and vexation, etc. with obvious therapeutic effect. Said dripping pill oral preparation is made up by using Chinese medicinal material Shanlucha as raw material and adopting a certain preparation process.

The present invention relates to a kind of medicine composition, Lemai dripping pill, with functions of activating vital energy, promoting blood circulation, alleviating mental depression, removing blood stasis, nourishing blood and dredging blood vessel and for treating coronary heart disease, atherosclerosis, pulmonary heart disease, infarct dementia, etc. The present invention has high bioavailability, fast medicine release, fast acting, high effective content, taking convenience and low cost, and the production process has no pollution. The Lemai dripping pill is prepared with seven kinds of Chinese medicinal materials, including red sage, Chuanxiong rhizome, red peony root, safflower, etc. and medicine carrier as matrix.

The invention relates to a polymer coagulant which contains the following components by weight percent: 5%-25% of anionic polyacrylamide, 5%-25% of cationic polyacrylamide, 5%-25% of non-ionic polyacrylamide, 3%-15% of dispersant and 40%-60% of water. The polymer coagulant is in solution state, and the range of pH value is 6.5-7.5; and the polyacrylamide is a water-soluble substance with a net structure. The polymer coagulant provided by the invention can be used in sewage treatment with larger change range of pH value and has high treatment efficiency and significant effects, and the clarity of water after the treatment is high; the polymer coagulant is in the solution state, has stable performances and can be configured to be the solution with very low concentration, the solution can not be degraded, the dosing quantity is convenient to control, when in use, the long-term dispersion and the stirring are unnecessary, the polymer coagulant can be used anytime and anywhere, and the operation is safe and convenient; and the polymer coagulant can be preserved for a long time, and the production cost can be reduced.

The invention discloses a medicinal composition for treating urinary lithiasis, pyelonephritis and cholecystitis, especially snowbell-leaf tickclover dripping pills and its preparation method, wherein the dripping pills are prepared from snowbell-leaf tickclover, and medicinal carrying agent as the base material. The dripping pills have the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, easy administering, low price, and no contamination in production.

The invention relates to a Lllicium henryi drop pill, which is a medicinal composition having the functions of repercussion, removing stasis, promoting blood circulation, relieving pain, treating waist and knee strain, articular muscle desmodynia and rheumatalgia. The aim of the invention is to provide a medicinal composition having the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, accurate administration dosage, low price, no acute allergic reaction or adverse effect, and facilitated transportation and carrying. The drop pill is prepared from traditional Chinese herb of Lllicium henryi as raw material, and medicinal carrying agent as the base material.

The invention discloses a makeup removal facial mask and a production method thereof. According to the production method, water is used as a solvent, glycerin, cetyl palmitate, PEG-7 olive oil ester, glyceryl cocoate, isohexadecane, polydimethylsiloxane, polysorbate-80 and polysorbate-20 are used as emulsifiers, cetearyl isononanoate, ceteareth-20, cetostearyl alcohol, glyceryl stearate and ceteareth-12 are used as emollients, phenoxyethanol and methylparaben are used as preservatives, sodium acrylate / sodium acryloyldimethyl taurate copolymer are used as a thickener; a purslane extract is used as a skin conditioner and essences are added, thus obtain the makeup removal facial mask. The production method disclosed by the invention is capable of reducing makeup removal steps, improving a makeup removal effect, and enhancing the usability of a makeup removal liquid; a makeup remover with nutrition to a certain extent is capable of still keeping the skin moist after makeup removal, more convenient to use, and better in effect.

The invention provides a preparation method of hydroxyl-terminated polymethylphenyl siloxane with controllable viscosity, which comprises the following steps: A) mixing methylphenylcyclosiloxane and methylcyclosiloxane, and dehydrating under vacuum conditions to obtain a dehydrated material; B) adding a double-hydroxy-terminated siloxane end-capping agent and a basic catalyst into the dehydrated material, heating to 90-110 DEG C, reacting for 3-6 hours, continuously heating to 120-160 DEG C, and introducing nitrogen to break the medium, with the dosage of the double-hydroxyl-terminated siloxane end-capping reagent calculated according to a formula (1) and accounting for 0.05%-5% of the total weight of the ring body; and C) removing low-boiling-point substances in the reaction product obtained in the step B) under a vacuum condition to obtain the viscosity-controllable hydroxyl-terminated polymethylphenyl siloxane with the structure shown in the formula I. The preparation method solvesthe problem of poor compatibility between the end-capping agent and the raw material, and finally, realizes the controllable viscosity of a methylphenyl 108 adhesive.

A dripping pill of bigelietong hydrochloride for treating diabetes is prepared from the bigelietong hydrochloride and the pharmacologically acceptable carrier.

The invention relates to a preparation method of a chamomile chewable tablet, which is characterized in that the preparation method comprises the following steps of (1) soaking, drying chamomile, removing a sweet and bitter taste of the chamomile, (2) respectively crushing and sieving dextrin, microcrystalline cellulose, dry starch, a filling agent and cane sugar, and then mixing uniformly, (3) adding water according to a proportion of 1g water to 7-8g auxiliary material mixture, preparing a soft material, (4) allowing the prepared soft material to pass through a 40-mesh sieve, drying till the moisture content is 2-5%, allowing obtained dry particles to pass through the 40-mesh sieve again, and (5) uniformly mixing a vitamin C, chamomile petals treated in Step (1) and the dry particles obtained from Step (4), spraying magnesium stearate on a mold, tableting at 240-340N, and conducting vacuum packaging. The chamomile chewable tablet is simple in technology, convenient to eat, sweet and sour in taste, complete in appearance, bright and clean in surface, moderate in hardness, easy to preserve and chewy, preserves nutritional ingredients of the chamomile and has a milk flavor and no rough sense when people have a taste; and the surface of the chamomile chewable tablet has natural flower patterns formed after the chamomile petals are squeezed.

The invention belongs to the technical field of biological medicines, and particularly relates to a trifunctional molecule combining CD19, CD3 and T-cell negative costimulatory molecules and an application of the trifunctional molecule. The trifunctional molecule structurally comprises a first functional domain, a second functional domain and a third functional domain, wherein the first functionaldomain can combine CD19, the second functional domain can combine and activate CD3, and the third functional domain can combine and block the T-cell negative costimulatory molecules. The trifunctional molecule has obvious advantages in terms of preparation process and practical application, the functions of activated T-cells are further improved while targeting of the T-cells for CD19 positive cells is achieved, the killing effect of the mediated T-cells on the CD19 positive target cells in individual addition is superior to that of CD19 / CD3 BiTE bispecific antibodies, and use convenience ofthe trifunctional molecule is superior to that of a targeted CD19 CAR-T technology.

The invention discloses a method for preparing an asphalt micro-meso analysis sample by adopting a silicone mold. According to the technical scheme, the method comprises the steps of preparing a mold; heating and pouring; scraping by utilizing a heat knife; carrying out secondary heating; fixing a mold glass slide; cooling and demolding; testing and observing. The mold is prepared by utilizing the characteristics of no toxicity, no odor, stable chemical property, good elasticity, high tensile strength, high temperature resistance, easiness in forming and demolding, and the like of silicon, the prepared analysis sample has a smooth surface, is high in flatness and uniform in thickness, various analysis samples meeting different requirements can be obtained by adjusting the shape, specification and size of a sample preparation mold, so that the specification requirement of test instruments such as a scanning electron microscope, an atomic force microscope and the like for different analysis samples can be met. According to the method, the operation is convenient, the analysis sample forming efficiency is high, the consumption of asphalt is controllable, and the method is ideal for preparing the asphalt micro-meso analysis sample.