Pyrolidone hydrochloride drip pill and its preparation method

Abstract

A dripping pill of bigelietong hydrochloride for treating diabetes is prepared from the bigelietong hydrochloride and the pharmacologically acceptable carrier.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating diabetes, in particular to a pharmaceutical composition oral preparation prepared from pioglitazone hydrochloride as a raw material. Background technique [0002] Type II diabetes mellitus (NIDDM) is the third largest disease in the world - the most common type of diabetes. Its main cause is insulin resistance, so long-term use of insulin therapy is not suitable, and the adverse reactions of sulfonylureas and biguanides are more obvious. Patients are not easy to accept. A class of hypoglycemic drugs developed in recent years that do not stimulate insulin secretion and act by enhancing the sensitivity of target tissues to insulin are thiazolidinedione derivatives, mainly including pioglitazone, troglitazone, Ciglitazone, englitazone, etc. can improve insulin resistance in patients, correct glucose and lipid metabolism disorders, and directly improve the toxicity of high glucose. This t...

AI Technical Summary

Problems solved by technology

[0007] Due to preparation technology and other reasons, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the efficacy of the drug. , also directly affects the therapeutic effect

In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment

Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

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