The invention relates to a high-yield milk cow feed mixture, which consists of the following ingredients in percentage by weight: 3 to 8 percent of bean dregs, 2 to 15 percent of cotton dregs, 1 to 3 percent of vegetable dregs, 2 to 5 percent of peanut meal, 0 to 20 percent of corn DDGS, 1 to 2 percent of stone dust, 0 to 15 percent of wheat bran, 0 to 3 percent of soybean oil, 0.2 to 1.5 percent of common salt, 1 to 2.5 percent of calcium hydrophosphate, 20 to 60 percent of corn, 0.2 to 1 percent of mineral substances and vitamin, 0.5 to 2 percent of phagostimulant and 5 to 30 percent of rumen health care agents. When the high-yield milk cow feed mixture of the invention is fed in the milk cow high-yield period, compared with the method of feeding ordinary milk cow feed sold in the market, the invention has the advantages that the daily milk yield of each mil cow can be increased by 2 to 5kg, in addition, the protein content, the fat content, the dry substance content and the like in the produced milk are all correspondingly increased, and the milk production quality can be improved.