54results about How to "Promotes repair and healing" patented technology

The invention discloses plastics for promoting the healing of skin wound and a preparation method of the plastics. The plastics comprises a traditional Chinese medicine solution and auxiliary materials, wherein the traditional Chinese medicine solution is derived from an alcohol extraction solution of a medicine composition, the pharmaceutical composition comprises Chinese angelica, radix notoginseng, baical skullcap root, phellodendron amurense, boswellia carterii, myrrh, common peony root, fructus forsythiae, radix et rhizoma rhei, honeysuckle flower, sinkiang arnebia root and liquorice; and the excipients comprise polyvinyl alcohol 1788, bletilla striata gelatin, chitosan, glycerol, polyethylene glycol 400, azone, eucalyptol, absolute ethyl alcohol, water, glacial acetic acid and borneol, and the volume of the traditional Chinese medicine solution to the auxiliary materials is 1:(4-5). The invention also provides a preparation method of the plastics for promoting skin wound healing. The plastics has the functions of effectively resisting bacteria and diminishing inflammation, invigorating the circulation of blood, removing blood stasis, resisting exudation and promoting the wound repairing and healing, and provides a new convenient, effective and safe path for promoting the healing of the wound.

The invention discloses a preparation method of a controllable hydrophobic bacterial cellulose-zein composite film. The method comprises the following steps: firstly, preparing and purifying a bacterial cellulose film; then soaking the bacterial cellulose film into an ethanol-water solution to perform replacement treatment; then preparing a zein solution; reacting the bacterial cellulose film and the zein solution, and performing solvent evaporation after reaction ends to obtain a bacterial cellulose-zein composite wet film; and performing drying treatment to obtain the bacterial cellulose-zein composite film. The prepared bacterial cellulose-zein composite film disclosed by the invention has adjustable high hydrophobicity, excellent mechanical performance and biocompatibility, and can play roles of controlling and enhancing the adhesion capacity of cells, accelerating the tissue repair, and the like; and moreover, the preparation method disclosed by the invention is simple and convenient to operate, can be suitable for large-scale industrial production, and has relatively good application prospects in biomedical material industry.

The present invention relates to a stress activity fiber film and a preparation method thereof, and belongs to the field of biomedical materials, wherein the stress activity fiber film comprises polyvinylidene fluoride nanometer fiber and composite nanometer fiber, the composite nanometer fiber comprises silk fibroin and a medical polymer synthesis material, a mass ratio of the silk fibroin to the medical polymer synthesis material in the stress activity fiber film is 1 / 20-1 / 1, a mass ratio of the polyvinylidene fluoride to the medical polymer synthesis material is 1 / 99-5 / 95, and by using the mixed solution of an electrospinning silk fibroin solution or a silk fibroin powder dispersion solution and a medical polymer synthesis material solution and a polyvinylidene fluoride solution, the interpenetrating nonwoven structure fiber film comprising the composite nanometer fiber (comprising the silk fibroin and the medical polymer synthesis material) and the polyvinylidene fluoride nanometer fiber is obtained. According to the present invention, the fiber film has characteristics of uniform and stable micro-structure and good biocompatibility, and can be widely used in tissue engineering scaffolds and wound or scar repair materials, wherein the fiber film is endowed with the stress activity due to the good piezoelectricity of the polyvinylidene fluoride nanometer fiber.

The invention discloses an extraction process and application of grifolan. The grifolan is obtained by adopting a method with the steps of water extraction, alkaline extraction, ultrafiltration and alcohol precipitation; it is discovered that the grifolan can promote gastric mucosa epithelial cells to proliferate and migrate to a gastric mucosa wound area by up-regulating mRNA and protein expression level of TFF2 and protein expression level of EGF and down-regulating mRNA and protein expression level of TGF-beta1; thus the aim of promoting gastric mucosa healing and plerosis is achieved, and a basis is provided for developing and using grifola frondosa and overcoming gastric mucosa wounds and chronic gastritis.

The invention particularly relates to a 3D printing skull repair titanium mesh containing growth factors and a preparation method thereof.The preparation method comprises the steps that a to-be-repaired head is analyzed, and skull defect part information is obtained; 3D printing is conducted according to the skull defect part information, and a titanium mesh skull model is obtained; adding the titanium mesh skull model into a dopamine solution to obtain a polydopamine microsphere modified titanium mesh skull model; mixing the hydroxyapatite, the microspheres, the collagen solution and the silk fibroin solution to obtain the 3D printing bio-ink; 3D printing bio-ink is printed into a coating to cover the polydopamine microsphere modified titanium mesh skull model, and after-treatment is conducted, the skull repair titanium mesh is obtained. The 3D printing titanium mesh and the guided tissue regeneration layer containing the growth factors are combined, the surface roughness and biological activity of the titanium mesh material can be improved, combination of the material and bones is promoted, adhesion and proliferation of cells are promoted, osteogenesis is induced, and repairing and healing of skull tissue are accelerated.

The invention discloses bone regeneration guiding collagen membrane for dental use and a preparation method thereof, and belongs to the technical field of regenerative medical materials. The preparation method of the bone regeneration guiding collagen membrane for dental use comprises the following steps: S1, preparing a raw material and carrying out pretreatment, including: S1-1, dissolving type-I collagen in an acidic solvent and carrying out homogenization so as to obtain collagen slurry, S1-2, filtering the collagen slurry, and S1-3, performing negative-pressure pumping on the collagen slurry filtered in S1-2 until no obvious bubbles exist; S2, carrying out freeze-drying, namely freeze-drying the collagen slurry prepared in S1 so as to obtain collagen sponge; S3, pressing the collagensponge into a thin piece, namely pressing the collagen sponge into a thin piece under a pressure of 1-5 MPa; and S4, performing severe dehydration and cross-linking on the thin piece in vacuum so as to obtain the bone regeneration guiding collagen membrane for dental use, and carrying out sterilizing and storing. The bone regeneration guiding collagen membrane for dental use disclosed by the invention can be used to stop bleeding and guide bone regeneration after dental implantation, and has the advantages of being low in immunogenicity, excellent in biocompatibility and capable of effectivelypromoting bone regeneration. Moreover, the preparation method of the bone regeneration guiding collagen membrane for dental use has the advantages of being efficient and easy in operation, non-toxicand harmless.

The invention discloses an external composition and an external medicine / hygiene product for prevention and treatment of gynecological reproductive tract diseases. The composition mainly comprises the following components in parts by weight: 0.3 to 30 parts of cactus, 0.1 to 10 parts of callicarpa nudiflora, 0.1 to 10 parts of Curcuma zedoaria, 0.1 to 10 parts of centella asiatica, 0.1 to 10 parts of lamiophlomis rotate, 0.05 to 5 parts of mint, and 0.0001 to 0.001 part of silver ions. The main preparation of the external medicine / hygiene product is a gel preparation, a cleaning liquid or an external instant effervescent tablet of the composition. The external composition has the characteristics of effectively inhibiting various pathogens and promoting healing of erosion, has an obvious effect for both prevention and treatment of gynecological reproductive tract infection, and is an excellent substitute of traditional external antibiotics and chemical disinfectants.

A medicine carried polyose membrane for treating the superficial ophthalmopathy by sticking it on eye area is prepared through preparing the aqueous solution of colloid from chitosan and carboxymethyl chitin or carboxymethyl chitosan or hyaluronic acid or hydroxyethyl chitosan, applying it on the concave mould made of stainless steel, centrifugal rotating while heating by electric light source or hot air to obtain dry membrane, neutralizing reaction, cross-linking reaction, sterilizing and immersing it in the antibiotic solution.

The invention relates to the field of antibacterial materials, in particular to guanidyl hyaluronic acid type antibacterial hydrogel as well as a preparation method and application thereof. Alkyl guanidines with different chain lengths are successfully connected to a carboxyl end side chain of hyaluronic acid in a chemical bond mode through a series of reactions, hyaluronic acid is endowed with antibacterial performance, and then guanidyl hyaluronic acid type antibacterial hydrogel is obtained through a ring-opening polymerization reaction by using a glycol diglycidyl ether crosslinking agent. The guanidyl hyaluronic acid type antibacterial hydrogel can also effectively inhibit the growth of bacteria and prevent wound infection, is an excellent antibacterial gel auxiliary material, and shows excellent antibacterial performance on gram-negative bacteria such as escherichia coli and gram-positive bacteria such as staphylococcus aureus; the cell compatibility is good; reaction conditions are easy to control, cost is low, and raw materials are easy to obtain; the antibacterial dressing can be used for wound injury, and has a good application prospect.

The invention provides a hollow porous absorbable suture line and a preparation method thereof. Non-absorbable woven yarn and absorbable axial yarn are prepared into the hollow porous absorbable suture line through the two-dimensional three-axial weaving technology and the thermal treatment technology. The preparation method comprises the steps that firstly, woven yarn and axial yarn are performedon the surface of a lining tube, a suture line with the porous surface is obtained, and the pore size is adjustable in the axial direction; then, due to the thermal treatment technology, the axial yarn is partially fused to fix a weaving point of the woven yarn; finally, the lining tube is removed, and the hollow porous suture line of the stable structure is obtained. The suture line is partiallyabsorbable, mechanical supporting can be ensured, and the non-absorbable ratio can be lowered; due to the hollow porous structure, tissue ingrowth is facilitated, tissue regeneration is promoted, when the suture line is in use, the stress of the suture line is in a ribbon shape, and cutting of tissue is reduced. By adopting the integrated forming technology by combining weaving and thermal setting, no welding, bonding and other post-treatment technologies are needed, the procedures are simple, and processing is convenient.

The invention discloses instant granules for treating gastrosis. The instant granules are prepared from, by weight, 20-28 parts of hericium erinaceus mycelium fermentation liquor, 20-25 parts of inonotus obliquus mycelium fermentation liquor, 18-25 parts of morchella mycelium fermentation liquor, 15-20 parts of grifola frondosa mycelium fermentation liquor, 8-10 parts of syzygium aromaticum, 10-15 parts of rhizoma atractylodis, 10-13 parts of officinal magnolia bark and 1-2 parts of probiotics. The invention further discloses a preparation method of the instant granules. The preparation method includes the steps that mycelia in the hericium erinaceus mycelium fermentation liquor, mycelia in the inonotus obliquus mycelium fermentation liquor and mycelia in the morchella mycelium fermentation liquor are subjected to wall breaking treatment respectively, filtering is carried out, and filter liquor is concentrated; syzygium aromaticum, rhizoma atractylodis and officinal magnolia bark are extracted, and extract liquor is concentrated and mixed with the filter liquor; probiotics are added, spray drying is carried out, and the mixture is prepared into the instant granules. Edible fungi, traditional Chinese medicine components and probiotics are used in combination, the combined effect of care and treatment is achieved, and the instant granules have a significant treatment effect on gastrosis, especially, gastritis.

The invention relates to a developing type degradable restoration pancreatic duct bracket, which is prepared from the following ingredients including 50 to 100 weight parts of degradable medical materials A, 0.1 to 50 weight parts of heeling restoration materials B, 0.001 to 0.05 weight part of developing agents C, 0.001 to 0.05 weight part of pancreatitis treating medicine D, or 0.001 to 0.05 weight part of antitumor medicine E. The developing type degradable restoration pancreatic duct bracket has the advantages that the biocompatibility is high; the form and the position of implanting materials can be fast judged; the degrading time is controllable; and in the complicated pancreatic duct rebuilding process, the effects of pressure reduction support, drainage, pancreatic duct heeling facilitation, convenience in pancreatic juice condition observation, postoperative pancreatic ductograph and the like can be achieved.

A preparation method of bimetallic organic framework antibacterial nanoparticles with a photothermal effect comprises the following steps: S1, respectively mixing potassium ferricyanide and anhydrouszinc chloride with deionized water, obtaining a solution A and a solution B respectively, and then mixing and stirring evenly the solution A and the solution B for standby application; S2, adding polyvinylpyrrolidone into the solution obtained in the step S1, stirring evenly, then adding hydrochloric acid, stirring evenly to make fully dissolved, and then carrying out static aging precipitation; S3, centrifuging the substance obtained in the step S2, separating a product solution to obtain a blue precipitate, and centrifuging and washing with ethanol and deionized water respectively, to obtaina precipitate product; and S4, placing the product obtained in the step S3 in a freezer, and freeze-drying. The method has the advantages that the precipitation aging method is used for controlling the stirring time in the synthetic process, and the nano cubic particles with uniform particle size can be controllably synthesized. Trace zinc ions can effectively promote cell proliferation and differentiation and promote wound repairing and healing, and the method is green and environmentally friendly.

The invention discloses a stomach-nourishing health care product preparation and a preparation method thereof. The preparation is composed of, by weight, 5-10 parts of vitacoenzyme, 5-10 parts of yeast, 10-15 parts of red dates, 7-13 parts of rhizoma atractylodis macrocephalae, 10-14 parts of radix astragali, 7-13 parts of fructus mori, 6-10 parts of tripterygium hypograucum, 2-5 parts of elecampane inula roots, 10-15 parts of raw malt, 7-12 parts of fructus crataegi, 5-9 parts of cortex magnoliae officinalis and 6-12 parts of fructus evodiae. All raw materials of the stomach-nourishing health care product preparation supplement one another, the effects of strengthening the spleen and the stomach, helping digestion and appetizing and tonifying qi and nourishing vital energy are achieved, gastric secretion can be promoted, pepsin activity is improved, gastric mucosa is protected, repairing and healing of gastric ulcer are promoted, chronic gastritis, atrophic gastritis, gastric ulcer and other common gastric diseases can be prevented and / or treated after the stomach-nourishing health care product preparation is taken for a long time, and organism immunity is enhanced.

The invention discloses a medicine for preventing and treating animal foot-and-mouth disease. The medicine is obvious in effect, free of toxic and side effects and medicine resistance, economical and effective, is a periplaneta-americana extract, and has the obvious treating effect on an application to treating animal foot-and-mouth disease, and the total effective rate can be 90% or above. After medicine dregs of extracted periplaneta americana are prepared into medicine dreg powder, the medicine dreg powder can be in cooperation with feed to treat foot-and-mouth-disease animals in an auxiliary mode, medicine dregs of periplaneta americana are fully used, and the objective economic value is achieved.

The invention discloses a grifolan extracting method and the pharmaceutical application thereof.Grifolan is obtained through aqueous extraction, alkaline extraction, acid extraction and alcohol precipitation.It is found that by improving the expression level of mRNA and protein of TFF2 and the expression level of protein of EGF and reducing the expression level of mRNA and protein of TGF-beta 1, proliferation of gastric mucosa epithelial cells and migration of gastric mucosa epithelial cells to a gastric mucosa wound area can be promoted, and then gastric mucosa healing and repairing are promoted and a basis is provided for development and utilization of grifola frondosa and treatment of gastric mucosa wounds and chronic gastritis.

The invention relates to a developing type degradable ureter repairing stent which is prepared from the following components: 50 to 100 weight parts of a degradable medical material A, 0.01 to 50 weight parts of a healing repairing material B, 0.001 to 0.05 weight part of a developing agent C and 0.001 to 0.05 weight part of an anti-infection medicine D. The developing type degradable ureter repairing stent is extremely high in biocompatibility, and the shape and the position of an implanted material can be quickly judged; the degradation time is controllable; in a complicated ureter reconstruction process, the developing type degradable ureter repairing stent achieves effects of pressure-reducing supporting, drainage, favorability of urethra healing, convenience for observation and postoperative ureter imaging and the like.

The invention discloses an absorbable medical hemostatic material and a preparation process thereof. The hemostatic material is prepared from the following components: fish scale collagen protein, maltodextrin, oligomannuronate, potassium alginate, D-threitol, polycaprolactone, 0.7 mol / L radix angelicae and alcohol extract, oxaloacetic acid, carboxyl glucan, gamma-polyglutamic acid, glycine ethyl ester, sodium D-glucuronate, microcrystalline cellulose 101, L-pentaguluronic acid pentasodium salt, citric acid and distilled water. The hemostatic material provided by the invention can stop bleeding quickly, is high in hemostasis rate, is higher in degrading speed in vivo, is non-toxic and high in biocompatibility, does not have immunoreactions, is high in capacity of healing and recovering a wound, can be used safely and reliably, and has a good market application prospect.

A bone fracture internal fixation material. The bone fracture internal fixation material is a hard absorbable bone fracture internal fixation material formed by embedding degradable acylated chitin as a main material and a degradable reinforcing agent as an auxiliary material into a whole, wherein the weight ratio of the acylated chitin to the reinforcing agent is 10:(0-10).

The invention relates to a composition for promoting postoperative wound healing, which is especially used for promoting cesarean section incision healing and scar repair and helping postpartum body recovery, and the invention also provides a preparation method of the composition, and the composition is mainly prepared from the following raw materials: marine fish oligopeptide, fish collagen, black-bone chicken, whey protein hydrolysate and water-soluble dietary fiber. The composition has the characteristics of being good in water solubility, easy to absorb and capable of helping the body of apuerpera to recover.

The invention relates to an absorbable intravascular stent and a preparation method thereof. The preparation method comprises the following steps: depositing a TiO2 film with a uniform structure on a PPDO monofilament by adopting an atomic layer deposition technology to obtain a titanized PPDO monofilament; taking the titanized PPDO monofilament as a core yarn and the PCL multifilament as a shell yarn to form a core-spun yarn in which the core yarn is completely wrapped by the shell yarn; respectively interweaving covering yarns and the titanium-infiltrated PPDO monofilament along opposite directions, coating the covering yarns and the titanium-infiltrated PPDO monofilament on the surface of a mold to form a woven intravascular stent embryo tube, and finally placing at high temperature to enable the covering yarns in contact with each other to be bonded at an interweaving point, so as to prepare the absorbable intravascular stent. The stent can be degraded in a water bath environment of deionized water at 37 DEG C, 70% of the yarns are broken on the 170th-195th day, and by regulating and controlling the TiO2 deposition thickness on the surface of the monofilament, a lumen is kept smooth and the size is stable about 6 months after the intravascular stent is implanted.

The invention discloses a wound hemostasis and repair product based on hyaluronic acid and a preparation method of the product.The wound hemostasis and repair product comprises a substrate and activegel located on the substrate, the substrate is a composite substrate, the composite substrate sequentially comprises a base material, a polydopamine layer, a titanium layer and a silver layer from bottom to top, a plurality of grooves are formed in the composite substrate, and the grooves are opened in the silver layer and reach the polydopamine layer in depth; and the active gel is based on hyaluronic acid, and the active gel based on hyaluronic acid is filled in the grooves and loaded on the upper surface of the whole composite substrate. The product of the invention has excellent antibacterial performance, can promote wound repair, inhibit wound bleeding, and can be effectively attached to wound skin in use by improving the structure of the composite substrate layer, at the same time, the wound dressing is not prone to deformation, gel slipping, etc., and the product is high in practicability.

The invention discloses a medicine, in particular to an epidermal growth factor culture fluid, a drug for external use which treats wounds of diabetes by adopting the culture fluid, and a preparation method thereof. Polypeptide active factors and chitosan are obtained by a gland tissue of a young of mammal through the in vitro culture process. The invention optimizes and is compatible with the polypeptide active factors and the chitosan which stimulate cell growth in different action mechanisms in order to achieve the same cooperated and intensified effects for accelerating the wound cicatrization. The product is applied to the treatment of diabetes and various wounds, has the cicatrization accelerating effect superior to the conventional treatment, and achieves satisfactory healing effects on other ulcerous skin injury. The development of the product not only provides a novel effective way for the treatment of the ulcer of diabetes wounds but also provides a better, rapider and more effective way for the conventional treatment of the wounds.

The invention discloses Chinese herbal preparation for treating post-anesthesia nerve injury, and belongs to the technical field of Chinese herbal medicine.According to traditional Chinese medicine theory, based on pathogenesis of post-anesthesia nerve injury, the Chinese herbal preparation is made of stylophorum lasiocarpum, mucuna macrocarpa wallich, gynurbicolor root, begonia grandis root, wild grapes, ligustrum lucidum ait, chonemorpha megacalyx pierre, grossdentate clematis root, benzoin, honeylocust root peel, eria graminifolia lindl, stem of hyacinth dolichos, japanese peristrophe herb, castor root, and semen brassicae.Through clinical practice, the Chinese herbal preparation has excellent effect.

The invention discloses an external medicine for fading and eliminating striae gravidarum and a preparation method thereof. The external medicine for fading and eliminating striae gravidarum and the preparation method are characterized in that effective components of the external medicine are prepared from the following raw medicines in parts by weight 78-234 parts of camellia oil, 1-3 parts of membranes of hen eggs, 0.5-1.5 parts of Sinkiang lithospermum, 1-3 parts of honeysuckles, 1-3 parts of liquorice roots, 1-3 parts of radix angelicae, 2-6 parts of centella asiatica, 1-3 parts of witch hazel, 1.5-4.5 parts of angelica sinensis, 1-3 parts of astragalus membranaceus, 1-3 parts of myrrh, 0.1-0.3 part of pearl powder and 1-3 parts of mint. Equipment comprises a crusher, a beaker, an ultrasonic oscillator, a No.8 sieve and a conical flask. The invention aims to provide the external medicine for fading and eliminating striae gravidarum and the preparation method thereof. The medicine has the advantages of remarkable curative effect, no side effect, low cost and convenience in use, and solves the problems existing in the prior art.

The present invention relates to a parasite prevention and / or treatment pharmaceutical composition, and the pharmaceutical composition comprises the following components: 5-20% of Fipronil, 4-18% of methoprene, 2-10% of an emollient, and the balance of a pharmaceutically acceptable carrier. The present invention also relates to a preparation method and application of the pharmaceutical composition in preparation of drugs for the prevention and / or treatment of pet diseases.

The invention discloses a bioelectricity-based wound surface repair sticker. The bioelectricity-based wound surface repair sticker comprises a repair sticker body; a nutrient solution layer is attached to one side of the repair sticker body; two enzyme electrodes are connected to two sides of the repair sticker body respectively; and one of the two enzyme electrodes is an anode, and the other oneis a cathode; and the enzyme electrodes contact with the nutrient solution. The repair sticker, based on a bioelectricity principle, can effectively promote the absorption of active ingredients by skin and improve the nourishing and repairing effect of the active ingredients for the skin.