34 results about "Carotid atherosclerosis" patented technology

Characterization of carotid atherosclerosis and classification of plaque into symptomatic or asymptomatic along with the risk score estimation are key steps necessary for allowing the vascular surgeons to decide if the patient has to definitely undergo risky treatment procedures that are needed to unblock the stenosis. This application describes a statistical (a) Computer Aided Diagnostic (CAD) technique for symptomatic versus asymptomatic plaque automated classification of carotid ultrasound images and (b) presents a cardiovascular stroke risk score computation. We demonstrate this for longitudinal Ultrasound, CT, MR modalities and extendable to 3D carotid Ultrasound. The on-line system consists of Atherosclerotic Wall Region estimation using AtheroEdge™ for longitudinal Ultrasound or Athero-CTView™ for CT or Athero-MRView from MR. This greyscale Wall Region is then fed to a feature extraction processor which computes: (a) Higher Order Spectra; (b) Discrete Wavelet Transform (DWT); (c) Texture and (d) Wall Variability. The output of the Feature Processor is fed to the Classifier which is trained off-line from the Database of similar Atherosclerotic Wall Region images. The off-line Classifier is trained from the significant features from (a) Higher Order Spectra; (b) Discrete Wavelet Transform (DWT); (c) Texture and (d) Wall Variability, selected using t-test. Symptomatic ground truth information about the training patients is drawn from cross modality imaging such as CT or MR or 3D ultrasound in the form of 0 or 1. Support Vector Machine (SVM) supervised classifier of varying kernel functions is used off-line for training. The Atheromatic™ system is also demonstrated for Radial Basis Probabilistic Neural Network (RBPNN), or Nearest Neighbor (KNN) classifier or Decision Trees (DT) Classifier for symptomatic versus asymptomatic plaque automated classification. The obtained training parameters are then used to evaluate the test set. The system also yields the cardiovascular stroke risk score value on the basis of the four set of wall features.

The invention belongs to the field of intersection of a computer technology and medical images, and in particular relates to an automatic dividing method of internal and external profiles in the cross section direction of an ultrasound image carotid artery blood vessel. The method specifically comprises the following steps of: selecting the current frame image; manually defining a reference profile point and interpolating to form a reference profile; extrapolating the reference profile to form a first interested area; automatically detecting a carotid artery profile: searching a radial gradient maximum point on a polar coordinate image obtained through conversion in a first interested area as the initial external profile point, estimating the gray probability density distribution in the first interested area by using mixed distribution, carrying out level set evolution to obtain the external profile, interpolating the external profile to form an initial internal profile and carrying out level set evolution to obtain an internal profile. By adopting the method, ultrasound carotid artery images can be effectively divided, and the workload of doctors can be reduced; and besides, the carotid artery internal and external profiles obtained through division in the method can be used for calculating the size of the carotid artery blood vessel wall and providing accurate and effective information for research of carotid atherosclerosis.

The invention discloses an application of Esculin to prevent and / or treat terminal advanced glycation end-products disease and Cardio-Cerebral-Vascular Disease, especially for the coronary atherosclerosis and arterial atherosclerosis, which is characterized by the following: cracking of terminal advanced glycation end-products, eliminating superoxide anion radical; protecting organism cell from Free-Raducak Injury; antagonizing Experimentative Hyperlipoidemia and decreasing Carotid Atherosclerosis formation. The invention has low toxicity, easy extraction, vast resource, good prospects, which is a perfect Chinese Herb to cure Cardio-Cerebral-Vascular Disease.

The invention relates to a traditional Chinese drug composition for treating carotid atherosclerosis plaque. The traditional Chinese drug composition comprises the following raw materials, wherein the raw materials comprise, by weight, 30-60 parts of mongolian milkvetch root, 12-26 parts of dangshen, 12-24 parts of angelica, 10-18 parts of szechwan lovage rhizome, 16-30 parts of rehmannia dride rhizome, 12-30 parts of dan-shen root, 12-18 parts of safflower, 20-60 parts of peach seed and 12-40 parts of lobed kudzuvine root. The traditional Chinese drug composition has advantages of scientific and reasonable formula, definite therapeutic effect, easy taking, and definite anti-arteriosclerosis therapeutic effect. With the traditional Chinese drug composition, the atherosclerotic plaque can be effectively eliminated so as to reduce the incidence and the re-admission rate of cardio-cerebrovascular important events. All the components of the traditional Chinese drug composition are the pure traditional Chinese drugs, no significant adverse reaction is generated, the safety is high, and the patient compliance is good. Compared to other drugs for treating the atherosclerosis, the traditional Chinese drug composition of the present invention has the following advantages that: the price is low, the traditional Chinese drug composition is easy to widely use in the community hospitals and the primary hospitals, such that the economic burden of the patient family and the society can be reduced, and the practicality is provided in the drug economics field.

The invention discloses an in-vitro foam cell formation model and application thereof in asymptomatic carotid atherosclerosis study. A construction method of the foam cell formation model provided bythe invention comprises the following steps: sequentially culturing, from bottom to top, smooth muscle cells, endothelial cells and mononuclear cells in a cell culture device capable of performing mechanical stretching so as to obtain a multi-cell co-culture system; treating the multi-cell co-culture system by utilizing a low density lipoprotein, applying a tension effect to induce formation of foam cells by virtue of the cell culture device capable of performing mechanical stretching, thus obtaining the foam cell formation model during early occurrence of asymptomatic carotid atherosclerosis.According to the method disclosed by the invention, consumption of an animal model can be reduced, expenditure is saved, an economic and high-efficiency in-vitro screening model is provided for carotid atherosclerosis resistant new drug screening, and the in-vitro foam cell formation model has the advantages of being simple in preparation method, convenient in experimental operation, low in timeconsumption and stable in performance.

The invention provides lumbrukinase and application thereof for preparing a medicament treating carotid atherosclerosis and a medicament containing the lumbrukinase as an active component.

The invention provides a medicine, particularly relating to a Chinese medicine composition for treating arteriosclerosis. The Chinese medicine composition for treating arteriosclerosis is characterized in that the mass portions of the components are: 1 to 2 grams of mint, 1 to 2 grams of chrysanthemum, 1 to 2 grams of cimicifuga foetida, 1 to 2 grams of bark of tree peony root, 1 to 2 grams of rhubarb, 1 to 2 grams of euphorbia kansui, 1 to 2 grams of common andrographis herb, 1 to 2 grams of asiatic plantain seed, 1 to 2 grams of akebia stem, 2 to 4 grams of orange peel, 2 to 4 grams of cyrtomium rhizome, 2 to 4 grams of baical skullcap root, 2 to 4 grams of abalone shell, 2 to 4 grams of safflower, 2 to 4 grams of salvia, 2 to 4 grams of earthworm, 2 to 4 grams of frankincense and 2 to 4 grams of jasper powder. The medicine of the invention is safe, effective and good in tolerance, so that the medicine can be routinely prescribed to treat a patient with carotid atherosclerosis and prevent cardiocerebrovascular events and has the advantages of safety and reliability, obvious curative effect, small side effect and high cure rate.

The invention relates to the technical field of medicine, and discloses a method for establishing a carotid arteriosclerosis and carotid plaque prediction model for common people. The method comprisesthe following steps: 1) selecting common people as modeling people; 2) collecting information; 3) grouping the modeling people, concretely, dividing the modeling people into a normal group and an abnormal group by taking the IMT maximum value of carotid arteries at the two sides as an evaluation index; 4) statistical modeling; and 5) prediction model evaluation. The method has the advantages thatthe prediction model is suitable for common physical examination crowds rather than high-risk crowds, the prediction efficiency of the prediction model is high, AUC reaches 0.88 or above, and the accuracy of the prediction model is 80% or above.

The present invention provides polymeric compositions, devices, and methods for repair of vascular injury, particularly endothelial injury and impaired vascular repair, such as from intracranial aneurysms and carotid atherosclerosis. The invention particularly provides polymers incorporating signaling factors useful for recruiting circulating vascular progenitor cells. The polymers can be used alone or as a coating for various devices for placement at sites of vascular injury to promote repair by the body's natural systems.

The invention discloses a medicated food for preventing and treating atherosclerosis. The medicated food is composed of the following raw materials in parts by weight: 500 to 1000 parts of crucian, 15 to 30 parts of red sage root, 5 to 10 parts of radix astragali, 5 to 10 parts of ginger, and 12 to 24 parts of jujube. The invention further discloses a preparation method and applications of the medicated food. The medicated food has the functions of boosting qi, activating blood, invigorating spleen, and tonifying kidney, is accord with the principle on treating atherosclerosis, and is capable of treating atherosclerosis effectively. The medicated food has a good effect during the preclinical phase of atherosclerosis, is capable of well preventing and treating coronary atherosclerotic cardiopathy, carotid atherosclerosis, renal atherosclerosis, and the like, and can be used to assist the therapy. The medicated food has the functions of boosting qi, activating blood, invigorating spleen, and tonifying kidney, has the advantages of fresh and delicious taste, rich nutrients, simple preparation, and low cost, is suitable for large-scale promotion and application, and has a good medical prospect.

The invention provides a method and device for evaluating cerebral apoplexy onset risk based on carotid atherosclerosis, and the method comprises the steps: building the corresponding relation betweenthe condition parameters of carotid atherosclerosis plaques and the cerebral apoplexy onset risk level through the self-learning capability of artificial intelligence; acquiring condition parametersof the current carotid atherosclerotic plaque of a current subject; determining a current cerebral apoplexy onset risk level corresponding to the condition parameter of the current carotid atherosclerotic plaque through the corresponding relationship, wherein specifically, the determining of the current cerebral apoplexy onset risk level corresponding to the condition parameter of the current carotid atherosclerotic plaque comprises the following steps: determining a cerebral apoplexy onset risk level corresponding to a condition parameter of a carotid atherosclerotic plaque, which is the sameas the condition parameter of the current carotid atherosclerotic plaque, in a corresponding relationship as the current cerebral apoplexy onset risk level. Quantitative estimation of cerebral apoplexy onset risk can be well realized through condition parameters of carotid atherosclerotic plaques.

The invention provides a construction method of a carotid atherosclerosis plaque animal model, and belongs to the field of animal model construction. According to the construction method, the common carotid artery intima of the central auricular artery injury is combined with high-fat feed for feeding and modeling. According to the invention, the carotid atherosclerosis plaque animal model is successfully constructed. The construction method comprises the step of modeling through a rabbit ear central artery approach; the animal model is simple in structure, small in wound, simple and convenient to operate, high in animal survival rate, high in modeling success rate and small in influence of other factors, solves the problems existing in construction of the carotid atherosclerosis plaque animal model in the prior art, can be used for screening drugs for treating atherosclerosis plaque and the like, and has important significance in research of carotid atherosclerosis.

The invention discloses an application of a Zhenlong refreshing pharmaceutical composition in preparation of a medicine for treating diabetic peripheral neuropathy. A Zhenlong refreshing preparation is traditionally used for treating acute cerebral infarction, carotid atherosclerosis plaque, apoplexy sequela, etc. Pharmacological experiments and clinical observations prove that the Zhenlong refreshing pharmaceutical composition disclosed by the invention comprises a Zhenlong refreshing capsule and a Zhenlong refreshing pharmaceutical composition prepared by an improved process, the Zhenlong refreshing pharmaceutical composition obviously perfects the symptoms of a nervous system of a DNP (diabetic peripheral neuropathy) patient and can significantly improve the nerve conduction velocity and perfect a variety of biochemical indexes, so that the Zhenlong refreshing pharmaceutical composition can be used for treating and preventing DPN.

The method belongs to the technical field of medical and zoological model building, and discloses a method for building an atherosclerosis animal model of disharmony between nutritive qi and defensiveqi. The method includes the following steps that an animal is anesthetized; superior thyroid ganglia is separated and exposed; a jugular sympathetic trunk is divided and ligated; suturing and disinfection are carried out; infection is prevented; the animal is fed with high-fat feed, vitamin D3 is injected into muscles, and air is blown. According to the technical scheme, the model of disharmony between nutritive qi and defensive qi is simulated through TCST, high-fat feed feeding is also used, and the atherosclerosis animal model of disharmony between nutritive qi and defensive qi is built, so that the problem that a carotid atherosclerosis animal experiment model with the symptom of disharmony between nutritive qi and defensive qi lacks in the prior art is solved. Due to the mode combining TCST, continuous air blowing, the high-fat feed and vitamin D, the model forming time of atherosclerosis can be greatly shortened, the experiment cost is reduced, the experiment time is shortened,and the method is economical, rapid to use and practical.

The invention relates to a Sanhuang freckle-removing decoction, and belongs to the technical field of traditional Chinese medicine preparation. The Sanhuang freckle removing decoction is prepared from the following components in parts by weight: 10-30 parts of radix astragali, 10-20 parts of sun-dried ginseng, 10-20 parts of rhizoma pinellinae praeparata, 10-20 parts of allium macrostemon, 10-20 parts of red yeast rice, 10-30 parts of radix salviae miltiorrhizae, 10-20 parts of radix notoginseng, 10-30 parts of radix scutellariae and 10-20 parts of rhizoma coptidis. The invention also discloses a preparation method of the Sanhuang freckle-removing decoction. The Sanhuang freckle-removing decoction disclosed by the invention has the beneficial effects of tonifying qi and reducing phlegm, activating blood and detoxifying, and has the advantages of stabilizing plaques, reducing blood fat, resisting inflammation, improving the life quality of patients, relieving clinical symptoms, having less side effects, being higher in safety and the like in the aspect of treating carotid atherosclerosis.

The invention discloses an evaluation method for carotid atherosclerosis. A medical image color ultrasound is applied to acquire an evaluation image. The evaluation method comprises the following steps: step S1, performing gray-scale ultrasonic scanning on a carotid artery; step S2, acquiring a plaque position and a stenosis degree according to a scanning result; step S3, performing vector blood imaging on the plaque position; step S4, generating a vascular wall stress evaluation threshold associated with the stenosis degree according to a dynamic vector blood flow image; and step S5, evaluating the condition of carotid atherosclerosis of a patient according to the evaluation threshold. According to the technical scheme, the gray-scale ultrasonic scanning and the vector blood flow imagingtechnology are combined, so that the hemodynamic change and the blood flow line change condition at the position of carotid artery stenosis can be visualized, and a diagnosis threshold with high sensitivity, high specificity and high accuracy is accurately acquired based on big data analysis. The evaluation method has extremely high applicability and clinical application value.

The invention belongs to the field of intersection of a computer technology and medical images, and in particular relates to an automatic dividing method of internal and external profiles in the cross section direction of an ultrasound image carotid artery blood vessel. The method specifically comprises the following steps of: selecting the current frame image; manually defining a reference profile point and interpolating to form a reference profile; extrapolating the reference profile to form a first interested area; automatically detecting a carotid artery profile: searching a radial gradient maximum point on a polar coordinate image obtained through conversion in a first interested area as the initial external profile point, estimating the gray probability density distribution in the first interested area by using mixed distribution, carrying out level set evolution to obtain the external profile, interpolating the external profile to form an initial internal profile and carrying out level set evolution to obtain an internal profile. By adopting the method, ultrasound carotid artery images can be effectively divided, and the workload of doctors can be reduced; and besides, the carotid artery internal and external profiles obtained through division in the method can be used for calculating the size of the carotid artery blood vessel wall and providing accurate and effective information for research of carotid atherosclerosis.

The present invention discloses an application of a traditional Chinese medicine composition made of radix astragali, honeysuckle, cortex phellodendri, rhizoma atractylodis, radix scrophulariae, Chinese angelica, radix paeoniae alba and coix seeds in preparation of drugs for treating carotid atherosclerosis with vulnerable plaque and belongs to the field of medicine. The composition reduces carotid intima-media thickness (IMT) by reducing total serum cholesterol, triglyceride, low-density lipoprotein and serum inflammation index Hs-CRP of patients, can stabilize the carotid atherosclerosis with the vulnerable plaque, and thus effectively reduces occurrence of acute cardiovascular and cerebrovascular events caused by the carotid atherosclerosis with the vulnerable plaque. The traditional Chinese medicine composition is low in toxic and side effects when used for treating the carotid atherosclerosis with the vulnerable plaque, has a precise therapeutic effect and has broad market prospects.

The invention discloses a carotid atherosclerosis rabbit model making and detecting method, which comprises seven steps of experimental material selection, grouping, model making, material taking, serum preparation, paraffin section and detection, wherein the model making step comprises two processes of feeding and operation applying. In the actual operation process, the complete carotid atherosclerosis model is established through early-stage experimental material selection, grouping and model making, detection materials are arranged through material taking, serum preparation, paraffin slicing, and the completeness of the model is verified.

The invention discloses an application of Esculin to prevent and / or treat terminal advanced glycation end-products disease and Cardio-Cerebral-Vascular Disease, especially for the coronary atherosclerosis and arterial atherosclerosis, which is characterized by the following: cracking of terminal advanced glycation end-products, eliminating superoxide anion radical; protecting organism cell from Free-Raducak Injury; antagonizing Experimentative Hyperlipoidemia and decreasing Carotid Atherosclerosis formation. The invention has low toxicity, easy extraction, vast resource, good prospects, which is a perfect Chinese Herb to cure Cardio-Cerebral-Vascular Disease.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating carotid arteriosclerosis and application thereof.The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-15 parts of rhizoma cyperi, 6-15 parts of ligusticum wallichii, 6-15 parts of rhizoma atractylodis, 6-15 parts of gardenia jasminoides, 6-15 parts of medicated leaven, 6-15 parts of hawthorns and 10-45 parts of corn stigma. The composition has the advantages that: (1) active pharmaceutical ingredients and the weight ratio of the active pharmaceutical ingredients are optimized, the medicines in the formula accord with the compatibility of monarch, minister, assistant and guide, and the medicines are combined to achieve the effect of relieving six depression; and (2) the composition can be prepared into clinically acceptable various dosage forms according to a conventional preparation method of medicines, the preparation method is simple and convenient, the sources of the active pharmaceutical ingredients are wide, the economic burden of a patient is greatly reduced, and the composition has very strong practicability and wide clinical application prospect.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition as well as an application and a preparation thereof. The traditional Chinese medicine composition contains lucid ganoderma, radix scrophulariae, salvia miltiorrhiza, coptis chinensis, thunberg fritillary bulb, raw oyster shell, angelica sinensis, prepared frankincense and prepared myrrh; clinical observation research finds that the prescription can averagely reduce the thickness of the transecting plaque of the carotid atherosclerotic plaque by 16.15%; a double-blind random control test shows that by adopting the formula, the transecting plaque thickness of the carotid atherosclerosis plaque can be averagely reduced by 11.48%; animal experiments find that the internal eliminating and vein softening decoction can activate UCP1, induce adipose tissue activation, promote whole body metabolism and significantly inhibit atherosclerotic plaques in a dose-dependent manner; and no obvious toxic or side effect is found.

The invention provides a preparation process of a mouse carotid artery injury model and an application thereof and belongs to the technical field of medical animal models. The preparation process includes: narcotizing a C57BL / 6 male mouse by injecting chloral hydrate in dosage of 300mg / kg into the abdominal cavity of the mouse, cutting along the carotid midline to form a 2-cm longitudinal incision, and covering one side of carotid artery by filter paper soaked with hydrogen peroxide to make injury on the carotid artery so as to prepare the mouse carotid artery injury model. The mouse carotid artery injury model can meet requirements for researches on forming and developing of blood clots after carotid artery internal membranes are subjected to injury, can actually simulate the pathological process of forming of blood clots after carotid artery internal membranes are subjected to injury in practical use, and lays a stable fundament for researching cardiovascular diseases in a system manner and particularly for researching forming of carotid atherosclerosis blood clots and further developing medicines for treating cardiovascular diseases and exploring therapeutic schedule and the like. In addition, the mouse carotid artery injury model can be prepared by simple operation within a short molding cycle, is high in success rate, good in repeatability, low in cost and easy to popularize and apply.