The invention discloses a 3D printing flexible socket with adaptability. The socket comprises a socket inner cavity and a socket shell, the inner cavity and the shell of the socket adopt 3D printing for integrated molding, and the printing material is a continuous fiber reinforcement composite material; the socket has the flexibility, the elastic modulus of the material used for making the socketis variable in the axial and radial gradient, and by adjusting technological parameters of 3D printing, the socket which has the elastic modulus gradient change and can achieve adaptability is manufactured. Accordingly, a prosthetic socket is prepared by adopting the continuous fiber composite printing mode, the weight is reduced, the strength is improved, and meanwhile by adopting the flexible design, the comfort degree of a stump of the part where a user making contact with the prosthetic socket is improved; integrated printing can improve the anastomosis degree of the socket inner cavity and the socket shell conveniently, the comfort degree of prosthetic wearing is increased, the preparation process time is shortened, and the manufacturing cost is greatly lowered.