87 results about "Skull repair" patented technology

The invention is a manufacturing method for titanium alloy cranial bone dummy, applies to cranial nerves surgery cranial bone renovation field. The invention assembles the dummy based on the CT picture of patient; the character lies in: the computer with universal image processing software and back designing software reconstructs the three-dimension prototype of patient head after dividing the fracture image, designs the dummy of defect part according to the three-dimension prototype, and the designed dummy curved surface is guided into multi-point forming system and quick-prototype system to press titanium network board and produce dummy slice model, finally forms the terminal dummy through comparing and cutting the titanium network board; the invention uses multi-point forming technology to compress the dummy quickly, it can uses the softness character of mouldless multi-point to compress the dummy in order to solves the back springing problem. The cost is low, the speed is high.

The preparation process of skull repairing body of titanium alloy for cerebral neurosurgery and other fields is based on the CT image scanning of the patient, assembling the repairing body, data analysis in computer with common image processing software and reverse design software, reconstituting the 3D prototype of the patient head, designing the repairing body based on the 3D prototype, making the repairing body mold via the fast prototype system, and pressing the netted titanium plate based on the mold to form final repairing body. The present invention features the making of the repairing body mold via digital design technology, fast forming system with special curved surface and gradually forming method to press the netted titanium plate. The repairing body of the present invention has high precision, low cost, fast making process and other advantages.

The invention discloses a personalized skull dummy and a preparation method thereof. In the personalized skull dummy, a medicinal metal material is used as a substrate, and a plurality of meshes are arranged on the substrate. The invention is characterized in that: the personalized skull dummy has a smooth profile edge; and the profile of the personalized skull dummy is matched with the profile of the defective part of the skull of a patient. The drawback that the edge of the skull metal dummy is coarsened when the edge profile of a skull metal dummy is trimmed after the three-dimensional forming of the skull metal dummy is accomplished in the prior art is overcome. The invention also discloses a preparation method of the personalized skull dummy, which comprises: acquiring the data on the skull image of a patient; performing the computer-based three-dimensional reconstruction of the skull and the computer-assisted design of the skull dummy; outputting dummy curved surface data output; acquiring a corresponding two-dimensional plane of the three-dimensional curved surface by computing; designing the skull dummy with the personalized profile by using the two-dimensional plane graphwith the specific edge profile; processing and forming the metal dummy; and the like.

The invention relates to the technical field of medical devices, in particular to a skull restoration body for inducing bone tissue regeneration and a preparation method thereof. The skull restorationbody has biological activity and comprises an inner inducing layer, a supporting layer and an outer inducing layer sequentially from the inside to the outside. The support layer is made of polyaryletherketone material which is equivalent to human bone strength, hardness and weight, and plays a supporting role. The inner inducing layer and the outer inducing layer are made of bioactive material, respectively arranged on the inner surface and the outer surface of the supporting layer, have good bioactivity and osteoinductivity, and can induce bone tissue regeneration. The support layer is provided with a plurality of mesh holes, and each mesh hole is filled with a bioactive material, which can promote the exchange of nutrients inside and outside the skull repair body, and is conducive to the growth of tissue. The preparation method of the skull prosthesis builds a digital model according to the skull data of the patient, so that the skull prosthesis and the skull defect part have high matching degree, and the operation difficulty is reduced.

The invention relates to a medical appliance, in particular to a biological degradable magnesium alloy reparation body and a bone screw which are used in skull wound and reshape and restoration. The reparation body and the bone screw are made from biological degradable pure magnesium or magnesium alloy, the reparation body is a thin board or thin slice of 0.03-0.2mm, at least two screw holes used for fixation are arranged on the surface thereof; by surface modification or coating, the bioactivity coat can be degraded, the surfaces of the reparation body and the bone screws have controllable degradation rate and excellent biological activity and compatibility. The biological degradable magnesium alloy reparation body and the bone screw of the invention can be used in skull wound and reshape and restoration of human body or animals.

The invention relates to a skull repairing anti-adhesion charged composite membrane and a preparation method thereof. The skull repairing anti-adhesion charged composite membrane and the preparation method thereof solves the technical problem that existing materials require further improvement in aspects of mechanical performance and electrical performance. The skull repairing anti-adhesion charged composite membrane is composed of high-molecular polymer and piezoelectric ceramic particles, wherein the high-molecular polymer is one or a compound of ferroelectric high-molecular polyvinylidene fluoride or polyvinylidene fluoride-trifluoroethylene. The invention also provides the preparation method of the skull repairing anti-adhesion charged composite membrane. The skull repairing anti-adhesion charged composite membrane and the preparation method thereof can be widely applied to the field of neurosurgical repair materials.

The invention provides an artificial skull repairing piece and a preparation method thereof. A 3D printing technology is adopted in the preparation method; autologous bone powder and hydroxyl calcium phosphate are used as basic raw materials of the artificial skull repairing piece, and thus the problem in biocompatibility of the artificial skull repairing piece is effectively solved; the outline dimension matching degree between the 3D printed artificial skull repairing piece and the defect part is high, and thus the working strength of doctors is greatly reduced; with good biocompatibility, the artificial skull repairing piece is conducive to inducing bone cell growth and promoting repairing; and due to high mechanical strength, the operation safety is improved.

The invention provides a bone plate for human skull defect repair and a preparing method and a using method of the bone plate. Compared with a titanium alloy net plate as the first choice for skull repair currently and clinically, the heat conductivity coefficient of the polyether-ether-ketone high polymer material bone plate is low, and the phenomenon of the encephalic discomfort generated by thesensitivity to temperature change after a patient adopts the titanium alloy net plate for repair is avoided. According to a skull defect part CT scanning picture of the patient, after the shape and the size of the defect part are determined, by individually designing processing and preparing, embedded installation and fixation are adopted by an operation, the preoperative cutting and shaping process of the repair of the titanium alloy net plate is replaced, it is avoided that the scalp is injured accidentally since the cutting edge of the titanium net plate is sharp, postoperatively, the outward leakage of cerebrospinal fluid and even a complication of infection caused when the sharp titanium net plate scratches the scalp are thoroughly removed, an artifact existing under an image by theadoption of the titanium alloy net plate for repair is also removed, and the influence of the artifact on later diagnosis and judgment of the state of illness clinically is effectively avoided.

The invention discloses a dissection type 3D printing net-shaped skull patch, and belongs to the technical field of skull repair. The skull patch comprises a skull patch edge matched with a brain injured part and a skull patch mesh structure, the skull patch edge is of a porous tentacle-free structure or pore-free tentacle-free structure or a pore-free tentacle structure. The skull patch mesh structure is formed by randomly weaving single-layer meshes or multi-layer meshes formed by beam structures. The skull patch is matched with the shape and dimension height of an original skull defect portion, and has the good anatomy and biological compatibility; meanwhile, the porous net-shaped design can effectively improve internal and external blood supply of the skull, after the skull patch is implanted, subcutaneous hematoma hematoma puncture drainage difficulty are likely to occur, the dropsy and infection occurrence rate can be lowered, and repairing and healing are promoted.

The invention belongs to the field of biological materials for tissue engineering repair and tissue regeneration promotion, and particularly relates to a preparation method and application of a blended hydrogel biological scaffold material with biological activity. The blended hydrogel biological scaffold material is prepared by sequentially mixing an acellular bone meal matrix and methacrylate-modified gelatin according to a certain proportion. The preparation method of the scaffold material provided by the invention is safe, non-toxic and easy to operate, the acellular bone meal with low immunogenicity is obtained by performing acellular treatment on bones of alpha-1,3-galactoside gene knockout pigs, and the acellular bone meal has the characteristic of low immunogenicity after being implanted into a living body. The tissue engineering scaffold material is obtained by blending the acellular bone meal with biological activity and low immunogenicity with the GelMA hydrogel, the hydrogel material mixed with the acellular bone meal reserves the extracellular matrix of a natural material, the hydrogel can also provide a good supporting effect for the scaffold material, the biocompatibility is good, and thereby the scaffold material can be used as a bone tissue engineering material to be applied to hard bone defects in vivo, skull repair and the like. Compared with a traditional treatment method, the scaffold material has wide application prospects.

The invention relates to a mineralized collagen based skull repairing device and a manufacturing method thereof. The mineralized collagen based skull repairing device is made of a mineralized collagen / PCL (polycaprolactone) composite material; and the appearance of the repairing device comprises a spherical segment cap at the upper part and a cylindrical plug at the lower part. A separation mold and a secondary pouring technology are adopted during preparation of the mineralized collagen based skull repairing device, and the product defect caused by air residue at the blind end of the mold is overcome. The skull repairing device made of the mineralized collagen / PCL composite material has excellent osteogenic activity, the material is gradually and passively degraded under the creeping substitution action of cells, and growth of new bones can be guided at the skull defect part. A degradation product of the composite material is neutral, acidic materials causing aseptic inflammation cannot be generated, and new bone formation isn't affected; and through composition of PCL, the skull repairing device has excellent elasticity and toughness besides enough crush resistance and bending strength, and the repairing requirement of a skull of a human body is met.

The invention discloses a carbon fiber composite skull repairing patch and a preparation method thereof. The skull repairing patch is formed by overlapping at least one layer of carbon fiber woven cloth and at least one layer of carbon fiber non-woven cloth. Carbon fibers of the carbon fiber woven fabric and the carbon fiber non-woven fabric are filled with matrix carbon and / or silicon carbide; the skull repairing patch has the characteristics of light weight, good biocompatibility, good chemical stability, mechanical properties similar to those of human bones, good fatigue, strong designability, no artifacts and the like, and is particularly suitable for skull repair.

The invention discloses an adjustable artificial bone repair system for repairing the alveolar bone, belongs to the fields of medical apparatus and instruments and bone repair materials, and particularly relates to an adjustable artificial bone repair system which can be used for repairing the alveolar bone. The system comprises four parts of a degradable natural polymer, a degradable artificial polymer, bioceramics and metal. Accordingly, bone substitutes conforming to forms, biological activity, mechanical properties, degradation / osteogenesis rate and the like of the defect parts are made for the defect parts. The bone repair system is mainly used for alveolar bone repair, and can also be used for dental implant making, skull repair, leg bone repair, cartilage repair and the like. By adding different components and adjusting the proportions of the different components, the target of satisfying different patients and bone substitutes of different bone tissue defects is achieved. The adjustable artificial bone repair system is suitable for 3D printing systems.

The invention discloses a titanium alloy skull repair prosthesis preparation method based on a metal powder laser sintering 3D molding technology. The titanium alloy skull repair prosthesis preparation method is characterized by comprising the following steps of: scanning a skull repair patient by a radiological technology, and reconstructing a model for a skull missing part by a reverse technology; performing 3D modeling for the skull missing part; pre-processing the skull repair prosthesis model; introducing the processed skull repair prosthesis model into a 3D molding device, scanning layers by layers until molding is completed; taking the completely processed skull repair prosthesis down from a processing platform together with a support by wire-electrode cutting; cutting the support down from the prosthesis by wire-electrode cutting, polishing the convex surface and edge of the prosthesis by a sand-blasting machine, and finally manually polishing until the surface of the prosthesis reaches technical requirements. The titanium alloy skull repair prosthesis preparation method adopts the bottom up type additive processing method, can achieve the quick molding of the skull repair prosthesis, and is not prone to being limited by shapes and thickness of the skull repair prostheses.

The invention belongs to the field of flexible forming of skull repairing bodies, and discloses a flexible forming device and a forming method of an amorphous alloy skull repairing body. The device comprises clamping units and a forming unit, wherein the clamping units are symmetrically arranged on the side surfaces of the forming unit; the forming unit comprises a tool head and laser devices; themultiple laser devices are uniformly arranged on the upper end of the tool head in the peripheral direction and are used for heating a to-be-machined zone before the to-be-machined zone below the tool head is machined by the tool head, so that a amorphous alloy plate of the to-be- machined zone is located in a supercooling liquid phase zone between a glass-transition temperature and an initial crystallization temperature; and the tool head rolls and forms the to-be-machined amorphous alloy plate along a preset trajectory layer by layer, so that flexible forming of the to-be-machined amorphousalloy plate is realized. Through the flexible forming device and the forming method, the biological compatibility of the obtained skull repairing body is good; bouncing of the repairing body is avoided; and the success rate of skull repairing surgery is improved.

The invention particularly relates to a 3D printing skull repair titanium mesh containing growth factors and a preparation method thereof.The preparation method comprises the steps that a to-be-repaired head is analyzed, and skull defect part information is obtained; 3D printing is conducted according to the skull defect part information, and a titanium mesh skull model is obtained; adding the titanium mesh skull model into a dopamine solution to obtain a polydopamine microsphere modified titanium mesh skull model; mixing the hydroxyapatite, the microspheres, the collagen solution and the silk fibroin solution to obtain the 3D printing bio-ink; 3D printing bio-ink is printed into a coating to cover the polydopamine microsphere modified titanium mesh skull model, and after-treatment is conducted, the skull repair titanium mesh is obtained. The 3D printing titanium mesh and the guided tissue regeneration layer containing the growth factors are combined, the surface roughness and biological activity of the titanium mesh material can be improved, combination of the material and bones is promoted, adhesion and proliferation of cells are promoted, osteogenesis is induced, and repairing and healing of skull tissue are accelerated.

The invention discloses a manufacturing method for manufacturing a skull repairing material by utilizing a three-dimensional (3D) printing technology. The manufacturing method for manufacturing the skull repairing material by utilizing the 3D printing technology comprises the following steps of before use, firstly acquiring patient skull CT image data; modeling and repairing data through professional software in a computer; copying into a 3D printer after processing; emitting an ultraviolet light to a glass window through an exposure module according to setting data; during the irradiating process, enabling a lifting mechanism to slowly and upwards slide so as to drive a base plate to move; during the base plate moving process, solidifying a rein in a resin groove irradiated by the ultraviolet light on the bottom part of the base plate, and enabling a resin which is not irradiated by the ultraviolet light to keep at a liquid state; after printing, taking out a printed skull model, manually cleaning, polishing, and carrying out postprocessing; after processing, cleaning, sterilizing and packaging the printed skull model; and after manually cleaning, polishing, and carrying out postprocessing on the printed skull model, placing in a sterile space, and curing for 20 to 30min.

The invention provides a reconstruction method and device for a skull defect structure and electronic equipment, and relates to the technical field of skull repair, the method comprises the followingsteps: obtaining three-dimensional image information of a pre-operation complete skull, defect edge contour information of an intraoperative defect skull and a main visual angle direction; rotating and projecting a first point set in the three-dimensional image information and a second point set in the defect edge contour information according to the main view angle direction, a preset rotating direction and a preset projection plane to obtain a first plane point set and a second plane point set; obtaining a target point set corresponding to the defected skull according to the first plane point set and the second plane point set; and performing three-dimensional reconstruction of the model structure on the target point set to obtain a target skull defect structure. A doctor does not need to manually segment the skull defect structure, errors caused by manual operation are reduced, and the skull defect structure reconstruction accuracy is improved.

The invention discloses a method for manufacturing a skull defect repair prosthesis. The manufacturing method comprises the following steps of 1) acquiring CT scan data of a skull; 2) performing three-dimensional reconstruction based on the CT scan data to obtain a three-dimensional skull model; 3) delineating a bone window of a skull with defects based on the three-dimensional model of the skull,and selecting at least 2 positions at the edge of the bone window; 4) at the positions selected in step 3), extending a reference arc from the edge of the bone window; 5) generating an inner surfaceprosthesis template and an outer surface prosthesis template through the reference arc; 6) performing intersection on the inner surface prosthesis template and the outer surface prosthesis template, taking a superposition part as a three-dimensional model of a skull repair prosthesis; 7) obtaining the skull repair prosthesis three-dimensional model, and processing to obtain the skull repair prosthesis according to step 6). The curvature and thickness of the skull repair prosthesis made by the method are closer to an original skull, the accuracy level of the skull repair prosthesis is improved,and original shape and appearance of skull defect portions are well restored.

The invention provides a manufacturing method of a surface modified artificial skull prosthesis, which comprises the following steps: 1, printing a solid PEEK skull prosthesis by using a 3D printer; 2, pretreating the PEEK skull prosthesis; 3, adsorbing and fixing type I collagen on the surface of the PEEK skull prosthesis through a physical effect to form a collagen adsorption layer; 4, carrying out crosslinking on the type I collagen by adopting Co-60 irradiation; and finally carrying out freeze vacuum drying. According to the method, the binding property of the PEEK material and the subcutaneous tissue can be remarkably improved, meanwhile, a chemical cross-linking agent is not used, the biocompatibility is good, the steps are relatively simple, and water resources are saved.

The invention discloses a skull repairing patch and a preparation method thereof. The skull repairing patch is formed by laminating one layer of carbon fiber knitted fabric and one or two layers of carbon fiber cloth, wherein the carbon fiber cloth is formed by overlapping carbon fiber woven cloth and carbon fiber non-woven cloth; matrix carbon and / or silicon carbide are / is filled between the carbon fibers of the carbon fiber knitted fabric and the carbon fiber cloth. The skull repair patch has the characteristics of light weight, good biocompatibility, good chemical stability, mechanical properties similar to those of human bones, good fatigue, strong designability, no artifacts and the like, and is particularly suitable for skull repair.

The invention discloses a 4D printed polyetheretherketone / niobate compound material and a preparation method thereof. The 4D printed polyetheretherketone / niobate compound material is mainly used for wound and skeleton repair in the biological medical field, such as skull repair, vertebral body replacement, and biological stents. Polyetheretherketone powder and niobate powder can be mixed together to be prepared into PEEK / niobate compound materials or to be used for coating niobate materials onto the surface of polyetheretherketone (fibers, sheets and stick materials), PEEK based compound materials are obtained through coating the surface of the PEEK / niobate compound material with biological degradable polymer materials, and through a 3D printing technique, a biological implant shape structure is shaped. The polyetheretherketone compound material has the characteristics of promoting generation of calcium and phosphorus salt on the surface of an implant, promoting proliferation and differentiation of osteocyte, promoting cell adhesion, being non-toxic, good in biocompatibility, simple in preparation method and the like.

The invention discloses an artificial skull repair material, and belongs to the technical field of orthopaedic repair materials. The artificial skull repair material comprises the following components in parts by weight: 15 to 29 parts of bone cement, 11 to 35 parts of a 3D (3-dimensional) titanium mesh, 11 to 17 parts of a polylactic acid composite material chitin and 15 to 21 parts of polyetheretherketone. The invention further provides a preparation method for the artificial skull repair material. A skull structure with a required radian can be rapidly prepared by adopting a 3D printing technology. The skull repair material comprising the components in parts by weight is processed to prepare skull prosthesis with any required radian by adopting the 3D printing technology, and is high in biocompatibility and low in cost, the advantages of materials such as the bone cement and the 3D titanium mesh are integrated, the shortcomings of a common skull repair material in terms of mechanical performance, processibility and consistency are effectively overcome, and meanwhile, side effects in clinical applications are obviously reduced.

The invention provides a hybrid cross-linked porous membrane of highly bionic bone matrix for skull repair, which is composed of a three-dimensional network of double cross-linked polymer and micron spherical hydroxyapatite uniformly distributed therein. The three-dimensional network of double cross-linked polymer is formed by oxidization and self-crosslinking of polymer materials with carboxyl and catechol functional groups, and Michael addition reaction of the polymer materials with carboxyl and catechol functional groups and the polymer materials with amino and carboxyl, and phenolic hydroxyl groups on the polymer materials with carboxyl and catechol functional groups chelated with calcium ions dissociated from the micron-sized spherical hydroxyapatite. According to the method, the dispersibility of the hydroxyapatite in the material can be improved, the integration degree of hydroxyapatite and an organic phase is increased, remodeling and regeneration of skull defect can be achieved without exogenous cells or growth factors.

The invention particularly relates to a skull repair polyether-ether-ketone material containing growth factors and a preparation method of the skull repair polyether-ether-ketone material, and belongs to the technical field of biomedical materials.The method comprises the steps that polyether-ether-ketone is formed, and a matrix is obtained; the preparation method comprises the following steps: modifying a matrix by using the polydopamine nano-microspheres to obtain a modified matrix; mixing a mineralization auxiliary agent with the guided tissue regeneration layer solution to obtain a mineralized guided tissue regeneration layer solution; mixing the microspheres loaded with the growth factors with a mineralization guided tissue regeneration layer solution to obtain a mineralization guided tissue regeneration layer solution containing the growth factors; mixing a cross-linking agent, a modification matrix and the mineralization guided tissue regeneration layer solution containing the growth factors to obtain a mixture; and reacting the mixture, drying, crosslinking, analyzing and sterilizing to obtain the skull repair polyether-ether-ketone material. Polydopamine nanoparticles are used for cross-linking modification of polyether-ether-ketone, raw materials are easy to obtain, safe and environmentally friendly, and hidden dangers brought to human bodies in the preparation process and the use of a final product are avoided.

The invention discloses a skull repairing device. The skull repairing device comprises a repairing material and one to six skull repairing pins, wherein the repairing material is in a net shape, each skull repairing pin is formed by connecting a repairing net hook, a repairing net clamping groove and a skull clamping groove in sequence, and the skull repairing pins are used for connecting the repairing material and the skull. The skull repairing device is simple in structure, the repairing material and the skull repairing pins are easy and convenient to machine, no special tool is required in an operation, and the repairing material and the skull are connected only by two minutes, so that the operation time is largely shortened; the repairing net hooks, the repairing net clamping grooves and the skull clamping grooves are matched, so that fixation is firmer. By the adoption of the fastening mode instead of the tight fixing mode, the skull repairing device can be used by children. Due to the skull repairing pins, certain elasticity is generated between the repairing material and the skull, and part of intracranial pressure can be lowered.

The invention discloses a clinical broken skull repairing device used in the neurosurgery department. The clinical broken skull repairing device comprises a protective cover and multiple mounting feetdetachably installed on the outer edge of the protective cover, wherein the installing feet comprise mounting sheets and fastening bolts, each fastening bolt is fixedly installed at one end of the corresponding mounting sheet and extends into the protective cover, the mounting sheets are provided with mounting holes, fixing columns are mounted in the mounting holes through penetration, mounting bases are mounted at the lower ends of the fixing columns, one mounting base is connected with another mounting base through a connector in a stretching way, and a loosening prevention bolt is mountedon the other mounting base. The clinical broken skull repairing device used in the neurosurgery department has the advantages that the protective cover covers the outside of the connecting part of thereturned skull to be repaired and the original skull of a patient to protect the returned skull, the returned skull is prevented from being bumped by foreign bodies, the safety is high, and the device is simple and convenient to mount and good in practicability.

The invention provides a special instrument set for skull repair fixation operations. The instrument set comprises a fixing clip and fixing forceps, wherein the fixing clip is installed on the fixing forceps; the fixing forceps comprise two handles, a No.1 forceps clip and a No.2 forceps clip, the two handles are movably connected through a bolt, the No.1 forceps clip and the No.2 forceps clip are fixed with front ends of the two handles respectively, and clamping grooves are formed in the No.1 forceps clip and the No.2 forceps clip and correspondingly communicated; the fixing clip comprises a No.1 clamping strip, a No.2 clamping strip, a base and a chuck, the lower end of the No.2 clamping strip is fixed in the No.1 clamping strip, and the base is fixed at the bottom of the No.1 clamping strip; a clamping strip hole is formed in the center of the chuck, and the No.1 clamping strip and the No.2 clamping strip are sleeved with the clamping strip hole; the No.2 clamping strip penetrates through the clamping grooves of the fixing forceps. The instrument set is reasonable in structural design, good in clamping effect and convenient to operate, cannot affect X-ray transmittance, and ensures operations to be successful.

The invention discloses a manufacturing method for an artificial skull repair prosthesis by the adoption of the 3D printing technology. The method is used for manufacturing the artificial skull repair prosthesis which is attractive in appearance, good in anastomosis and few in complication for skull-defect patients. The manufacturing method for the artificial skull repair prosthesis has the advantages that according to the manufacturing method, the skull is manually manufactured by the adoption of the 3D printing technology to repair and rebuild the skull of a patient, so that the defects, in molding, strength, process, anastomosis and the like, of common skull repair materials are overcome, the manufacturing cycle is greatly shortened, and the side effects of clinical application are remarkably reduced.

The invention particularly relates to a skull repair polyether-ether-ketone material and a preparation method thereof, and belongs to the technical field of biomedical materials.The method comprises the steps that a head to be repaired is analyzed, and skull defect part information is obtained; forming polyether-ether-ketone according to the skull defect part information to obtain a matrix; the preparation method comprises the following steps: modifying a matrix by using the polydopamine nano-microspheres to obtain a modified matrix; mixing the calcium nitrate tetrahydrate solution, the diammonium hydrogen phosphate solution and the guided tissue regeneration layer solution to obtain a mineralized guided tissue regeneration layer solution; mixing a cross-linking agent, a modification matrix and the mineralization guided tissue regeneration layer solution to obtain a mixture; and reacting the mixture, drying, crosslinking, analyzing and sterilizing to obtain the skull repair polyether-ether-ketone material. Polydopamine nanoparticles are used for cross-linking modification of polyether-ether-ketone, raw materials are easy to obtain, safe and environmentally friendly, and hidden dangers brought to human bodies in the preparation process and the use of a final product are avoided.