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Adjustable artificial bone repair system for repairing alveolar bone

A repair system and artificial bone technology, applied in the field of medical devices, can solve the problems of single bone substitutes with single properties, failure to meet the comprehensive needs of bone repair materials, lack of allogeneic bone materials, etc.

Inactive Publication Date: 2019-07-12
SHANDONG BRANDEN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since autologous bone will cause additional damage to the human body, allogeneic bone materials are lacking, and a single bone substitute has a single property, which cannot meet the comprehensive needs for bone repair materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Set the system components as follows: ①The component ratio is 40%, of which collagen: chitosan is 30%:70%; ②The component is PLGA, accounting for 10%; ③The component ratio is 47% , of which hydroxyapatite: biphasic calcium phosphate is 60%: 40%; ④ component is titanium alloy: degradable zinc alloy is 85%: 15%, accounting for 3%. The prepared sample has a thickness of 1 mm, a width of 1 cm, and a length of 5 cm. The measured tensile strength of the system is 7.1MPa, the biocompatibility is good, the cytotoxicity in vitro is 0, and the degradation rate is about 12mm 3 / moon. This system can be applied to alveolar bone repair.

Embodiment 2

[0012] Set the system components as follows: ①The proportion of components is 5%, of which collagen: chitosan is 90%: 10%; ②The component is PLA, accounting for 1%; ③The component is active glass, so The proportion is 40%; ④The component is titanium alloy: the degradable zinc alloy is 85%:15%, and the proportion is 54%. The prepared sample has a thickness of 1 mm, a width of 1 cm, and a length of 5 cm. The measured bending strength of the system is 161MPa, the biocompatibility is good, the cytotoxicity in vitro is 0, and the degradation rate is about 7mm / year. The system can be applied to cranial repair.

Embodiment 3

[0014] Set the system components as follows: ①The proportion of components is 5%, of which collagen: alginate is 80%: 20%; ②The component is PCL, accounting for 2%; ③The component is active glass, The proportion is 10%; ④The component is titanium alloy: the degradable zinc alloy is 70%:30%, and the proportion is 83%. The prepared sample has a thickness of 1 mm, a width of 1 cm, and a length of 5 cm. The measured tensile strength of the system is 130MPa, the biocompatibility is good, the cytotoxicity in vitro is 0, and the degradation rate is about 3.5mm / year. This system can be applied to leg bone repair.

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Abstract

The invention discloses an adjustable artificial bone repair system for repairing the alveolar bone, belongs to the fields of medical apparatus and instruments and bone repair materials, and particularly relates to an adjustable artificial bone repair system which can be used for repairing the alveolar bone. The system comprises four parts of a degradable natural polymer, a degradable artificial polymer, bioceramics and metal. Accordingly, bone substitutes conforming to forms, biological activity, mechanical properties, degradation / osteogenesis rate and the like of the defect parts are made for the defect parts. The bone repair system is mainly used for alveolar bone repair, and can also be used for dental implant making, skull repair, leg bone repair, cartilage repair and the like. By adding different components and adjusting the proportions of the different components, the target of satisfying different patients and bone substitutes of different bone tissue defects is achieved. The adjustable artificial bone repair system is suitable for 3D printing systems.

Description

technical field [0001] The invention belongs to the field of medical equipment and bone repair treatment, and in particular relates to an adjustable artificial bone repair system made of multiple materials and a preparation method thereof. Background technique [0002] At present, human hard tissue damage caused by accidents and diseases is increasing year by year, and bone repair materials are important medical materials used as bone substitutes to treat bone tissue damage. Depending on the nature of the bone injury site, the properties of the required bone repair materials are also different. For example, the repair of alveolar bone requires a repair material with high mechanical strength, good biocompatibility, and a degradation rate compatible with the bone regeneration rate, such as hydroxyl Apatite composite materials, etc. At present, there are 3D printing technologies that can customize bone substitutes according to the actual shape of the bone loss site, but there ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/20A61L27/18A61L27/12A61L27/06A61L27/04A61L27/10A61L27/50A61L27/58B33Y70/00
CPCA61L27/047A61L27/06A61L27/10A61L27/12A61L27/18A61L27/20A61L27/24A61L27/50A61L27/58A61L2430/02B33Y70/00C08L5/08C08L67/04
Inventor 张海军张军伟周超冯相蓺崔晓珊宋彩霞赵彦伟徐凯丽侯文博尹玉霞鲁手涛段翠海刘光王鲁宁万国江
Owner SHANDONG BRANDEN MEDICAL DEVICE
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