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Skull repairing anti-adhesion charged composite membrane and preparation method thereof

An anti-adhesion and composite film technology, which is applied in the field of repair materials for neurosurgery, achieves the effect of inducing skull repair performance, avoiding side effects, and improving osteoinductive activity

Inactive Publication Date: 2017-10-10
PEKING UNIV SCHOOL OF STOMATOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to solve the technical problem that the mechanical properties and electrical properties of existing materials need to be further improved, and provides an anti-adhesion electrified composite film for cranial repair with greatly improved material mechanical properties and electrical properties and its preparation method

Method used

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  • Skull repairing anti-adhesion charged composite membrane and preparation method thereof
  • Skull repairing anti-adhesion charged composite membrane and preparation method thereof
  • Skull repairing anti-adhesion charged composite membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Take appropriate amount of BaTiO 3 Ceramic particles were dispersed in 5mL organic solvent DMF by ultrasonic oscillation, and ultrasonic oscillation was combined with stirring for 3 hours to obtain a ceramic particle dispersion;

[0028] (2) Weigh 1g of P(VDF-TrFE), add 5mL of organic solvent DMF, stir for 6h to dissolve completely, and obtain polymer P(VDF-TrFE) solution;

[0029] (3) Add the dispersion liquid obtained in step (1) to the polymer solution obtained in step (2), and stir for 10 h so that the ceramic particle filler is evenly dispersed in the polymer P(VDF-TrFE) matrix to obtain a mixed liquid;

[0030] (4) Casting the mixed solution obtained in step (3) in a casting machine, drying the obtained casting film at a temperature of 55° C. to completely volatilize the solvent to obtain a composite film material with a film thickness of 100 μm;

[0031] (5) The film material obtained in step (4) is subjected to polarization treatment, and the polarization p...

Embodiment 2

[0034] (1) Take an appropriate amount of potassium sodium niobate ceramic particles and disperse them in 5 mL of organic solvent DMF by ultrasonic oscillation, and use ultrasonic oscillation combined with stirring for 2 hours to obtain a ceramic particle dispersion;

[0035] (2) Weigh 1g of PVDF, add 5mL of organic solvent DMF, stir for 4h to dissolve completely, and obtain polymer PVDF solution;

[0036] (3) adding the dispersion obtained in step (1) to the polymer solution obtained in step (2), stirring for 8 hours so that the ceramic particle filler is evenly dispersed in the polymer PVDF matrix to obtain a mixed solution;

[0037] (4) Casting the mixed solution obtained in step (3) in a casting machine, drying the obtained casting film at a temperature of 60° C. to completely volatilize the solvent to obtain a composite film material with a film thickness of 80 μm;

[0038] (5) The membrane material obtained in step (4) is subjected to polarization treatment, and the polar...

Embodiment 3

[0041] (1) Take an appropriate amount of lithium niobate ceramic particles and disperse them in 5 mL of organic solvent DMF by ultrasonic oscillation, and use ultrasonic oscillation combined with stirring for 2 hours to obtain a ceramic particle dispersion;

[0042] (2) Weigh 1g of P(VDF-TrFE), add 5mL of organic solvent DMF, stir for 5h to completely dissolve, and obtain polymer P(VDF-TrFE) solution;

[0043] (3) Add the dispersion liquid obtained in step (1) to the polymer solution obtained in step (2), and stir for 8 hours so that the ceramic particle filler is evenly dispersed in the polymer P(VDF-TrFE) matrix to obtain a mixed liquid;

[0044] (4) Casting the mixed solution obtained in step (3) in a casting machine, drying the obtained casting film at a temperature of 45° C. to completely volatilize the solvent to obtain a composite film material with a film thickness of 60 μm;

[0045] (5) The membrane material obtained in step (4) is subjected to polarization treatment,...

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Abstract

The invention relates to a skull repairing anti-adhesion charged composite membrane and a preparation method thereof. The skull repairing anti-adhesion charged composite membrane and the preparation method thereof solves the technical problem that existing materials require further improvement in aspects of mechanical performance and electrical performance. The skull repairing anti-adhesion charged composite membrane is composed of high-molecular polymer and piezoelectric ceramic particles, wherein the high-molecular polymer is one or a compound of ferroelectric high-molecular polyvinylidene fluoride or polyvinylidene fluoride-trifluoroethylene. The invention also provides the preparation method of the skull repairing anti-adhesion charged composite membrane. The skull repairing anti-adhesion charged composite membrane and the preparation method thereof can be widely applied to the field of neurosurgical repair materials.

Description

technical field [0001] The invention relates to the technical field of repair materials for neurosurgery, in particular to an anti-adhesion electrified composite film for skull repair and a preparation method thereof. Background technique [0002] The skull not only helps to maintain the shape of the head and face, but also acts as a barrier between the brain and the outside world. Skull defect is a common secondary disease clinically. It is mainly seen in various traumas and postoperatives, such as electric shocks, traffic accidents, gunshot wounds, resection of malignant skull tumors, congenital deformities, and decompressive craniectomy. Ideal repair materials for skull defects need to be easy to obtain, have high biocompatibility, reconstruct skull contours, and have the potential to induce osteogenesis. Defects such as tissue adhesion lead to poor long-term clinical effect. [0003] In recent years, electroactive materials have become a research hotspot and trend of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/50
CPCA61L27/44A61L27/50A61L2300/412A61L2430/02C08L27/16
Inventor 邓旭亮张学慧
Owner PEKING UNIV SCHOOL OF STOMATOLOGY
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