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3D-printed skull repair titanium mesh containing growth factors and preparation method of 3D-printed skull repair titanium mesh

A growth factor, 3D printing technology, applied in 3D printing, skulls, manufacturing tools, etc., can solve the problem of ineffective induction of new bone formation, and achieve the effect of increasing surface roughness and biological activity, promoting bonding, and promoting adhesion

Pending Publication Date: 2022-05-17
ASIA BIOMATERIALS WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The purpose of this application is to provide a 3D printed titanium mesh containing growth factors for skull repair and its preparation method to solve the problem that the current use of finished titanium mesh alone cannot effectively induce new bone formation

Method used

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  • 3D-printed skull repair titanium mesh containing growth factors and preparation method of 3D-printed skull repair titanium mesh
  • 3D-printed skull repair titanium mesh containing growth factors and preparation method of 3D-printed skull repair titanium mesh

Examples

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preparation example Construction

[0057] According to a typical embodiment of the present invention, a method for preparing a 3D printed titanium mesh for skull repair containing growth factors is provided, the method comprising:

[0058] S1. Analyze the head to be repaired to obtain the information of the skull defect;

[0059] Specifically, plain and enhanced CT scans of the head defect are performed first, and then three-dimensional reconstruction is performed to determine the position, size, and shape of the head and skull defects.

[0060] S2. Perform 3D printing according to the information of the skull defect site to obtain a titanium mesh skull model;

[0061] Import the scanned data into the software to design the bone defect model, save it in STL format and import it into the 3D printer, use the software to correct and calibrate the bone defect model, use digital equipment to shape according to the model data, and make a model that matches the defect. Titanium mesh, the edge of the titanium mesh sho...

Embodiment 1

[0108] A preparation method for 3D printing skull repair titanium mesh containing growth factors, the steps are as follows:

[0109] S1. Preparation of 3D printed titanium mesh. First, carry out plain and enhanced CT scans of the head defect, and then perform 3D reconstruction to determine the position, size, shape, etc. of the skull defect; import the scanned data into the software for bone defect model design, save it in STL format and import it into 3D The printer uses software to correct and calibrate the bone defect model, and uses digital equipment to shape according to the model data to produce a titanium mesh that matches the defect. The edge of the titanium mesh should exceed the edge of the defect by 1cm. The chemical composition of the pure titanium restoration conforms to the standard of GB / T 13810-2017 "Titanium and Titanium Alloy Processing Materials for Surgical Implants". There is a titanium nail hole at the end of the block. The thickness of the titanium mes...

Embodiment 2

[0115] A preparation method for 3D printing skull repair titanium mesh containing growth factors, the steps are as follows:

[0116] S1. Preparation of 3D printed titanium mesh. First, carry out plain and enhanced CT scans of the head defect, and then perform 3D reconstruction to determine the position, size, shape, etc. of the skull defect; import the scanned data into the software for bone defect model design, save it in STL format and import it into 3D The printer uses software to correct and calibrate the bone defect model, and uses digital equipment to shape according to the model data to produce a titanium mesh that matches the defect. The edge of the titanium mesh should exceed the edge of the defect by 1cm. The chemical composition of the pure titanium restoration conforms to the standard of GB / T 13810-2017 "Titanium and Titanium Alloy Processing Materials for Surgical Implants". There is a titanium nail hole at the end of the block. The thickness of the titanium mes...

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Abstract

The invention particularly relates to a 3D printing skull repair titanium mesh containing growth factors and a preparation method thereof.The preparation method comprises the steps that a to-be-repaired head is analyzed, and skull defect part information is obtained; 3D printing is conducted according to the skull defect part information, and a titanium mesh skull model is obtained; adding the titanium mesh skull model into a dopamine solution to obtain a polydopamine microsphere modified titanium mesh skull model; mixing the hydroxyapatite, the microspheres, the collagen solution and the silk fibroin solution to obtain the 3D printing bio-ink; 3D printing bio-ink is printed into a coating to cover the polydopamine microsphere modified titanium mesh skull model, and after-treatment is conducted, the skull repair titanium mesh is obtained. The 3D printing titanium mesh and the guided tissue regeneration layer containing the growth factors are combined, the surface roughness and biological activity of the titanium mesh material can be improved, combination of the material and bones is promoted, adhesion and proliferation of cells are promoted, osteogenesis is induced, and repairing and healing of skull tissue are accelerated.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, in particular to a 3D printed titanium mesh for skull repair containing growth factors and a preparation method thereof. Background technique [0002] Skull defect is a common secondary disease clinically. It is mainly seen in various traumas and postoperatives, such as electric shocks, car accident injuries, gunshot wounds, resection of malignant skull tumors, congenital deformities, and decompressive craniectomy. In principle, skull defects with a maximum diameter of more than 3 cm require skull reconstruction surgery. When the skull defect exceeds 3 cm, clinical symptoms can occur. Successful skull reconstruction needs to meet three requirements: (1) maintain the integrity of the dura mater, that is, the protection of the brain; (2) protect the barrier between the brain and the outside world, that is, biomechanical stability; (3) maintain the normal state of the head The domed s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61L27/06A61L27/18A61L27/32A61L27/34A61L27/54B33Y80/00B33Y70/10B33Y10/00
CPCA61F2/2875A61L27/06A61L27/18A61L27/32A61L27/34A61L27/54B33Y80/00B33Y70/10B33Y10/00A61F2002/2835A61F2002/2817A61F2002/3006A61F2002/3093A61F2002/30985A61L2430/02A61L2300/414A61L2300/606A61L2420/04A61L2420/06C08L79/04C08L89/00
Inventor 唐三王喆周雄
Owner ASIA BIOMATERIALS WUHAN CO LTD
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