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Absorbable intravascular stent and preparation method thereof

A vascular stent, the technology of the opposite direction, applied in the field of luminal stents, can solve the problem of uncontrollable degradation time of absorbable vascular stents, and achieve the effects of good blood vessel healing and repair, regulation of degradation rate, and delay of degradation rate

Active Publication Date: 2021-08-10
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problem of uncontrollable degradation time of absorbable vascular stents in the prior art, the present invention provides an absorbable vascular stent with adjustable degradation rate and its preparation method

Method used

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  • Absorbable intravascular stent and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] figure 1 Schematic diagram of braided vascular stent for titanium-infiltrated PPDO / PCL. Such as figure 1 As shown, an absorbable vascular stent of this embodiment is formed by interweaving core-spun yarns and titanium-infiltrated PPDO monofilaments, and the interweaving points of the core-spun yarns are fixed by welding. The core yarn of the core-spun yarn is a titanium-infiltrated PPDO monofilament, the sheath yarn is a PCL multifilament, and the sheath yarn completely covers the core yarn. The titanium-infiltrated PPDO monofilament includes a titanium dioxide film covering the surface of the PPDO monofilament substrate.

[0034] Preferably, the thickness of the titanium dioxide film is 10 -8 m~3×10 -8 m.

[0035] Preferably, the titanium dioxide thin film is coated layer by layer on the surface of the PPDO monofilament substrate in the form of a monoatomic film.

Embodiment 2

[0037] A method for an absorbable vascular stent that can regulate the degradation rate, the specific steps are as follows:

[0038] (1) First heat the ALD chamber to 70°C, then put the PPDO monofilament into the ALD reactor for TiO2 deposition, and deposit 400 deposition cycles to obtain titanium-infiltrated PPDO monofilament;

[0039]The process of a single deposition cycle is as follows: keep 1h under the pressure of 0.1Torr, use high-purity nitrogen (99.999%) and ordinary nitrogen (99.9%) as the carrier gas and purge gas of the ALD process, titanium isopropoxide and H2O As the precursor source, it enters the ALD reactor through alternate pulses of the carrier gas; when the carrier gas is alternately pulsed, the pulse time of titanium isopropoxide and H2O is 1s; after the pulse, each precursor is kept in the chamber for 40s to make PPDO The monofilament substrate is fully exposed to the precursor vapor, and then the reaction chamber is purged with ordinary nitrogen at a flo...

Embodiment 3

[0046] A method for an absorbable vascular stent that can regulate the degradation rate, the specific steps are as follows:

[0047] (1) First heat the ALD chamber to 80°C, then put the PPDO monofilament into the ALD reactor for TiO2 deposition, and deposit 200 deposition cycles to obtain titanium-infiltrated PPDO monofilament;

[0048] The process of a single deposition cycle is as follows: keep 1h under the pressure of 0.1Torr, use high-purity nitrogen (99.999%) and ordinary nitrogen (99.9%) as the carrier gas and purge gas of the ALD process, titanium isopropoxide and H2O As the precursor source, it enters the ALD reactor through alternate pulses of the carrier gas; when the carrier gas is alternately pulsed, the pulse time of titanium isopropoxide and H2O is 1s; after the pulse, each precursor is kept in the chamber for 40s to make PPDO The monofilament substrate is fully exposed to the precursor vapor, and then the reaction chamber is purged with ordinary nitrogen at a fl...

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Abstract

The invention relates to an absorbable intravascular stent and a preparation method thereof. The preparation method comprises the following steps: depositing a TiO2 film with a uniform structure on a PPDO monofilament by adopting an atomic layer deposition technology to obtain a titanized PPDO monofilament; taking the titanized PPDO monofilament as a core yarn and the PCL multifilament as a shell yarn to form a core-spun yarn in which the core yarn is completely wrapped by the shell yarn; respectively interweaving covering yarns and the titanium-infiltrated PPDO monofilament along opposite directions, coating the covering yarns and the titanium-infiltrated PPDO monofilament on the surface of a mold to form a woven intravascular stent embryo tube, and finally placing at high temperature to enable the covering yarns in contact with each other to be bonded at an interweaving point, so as to prepare the absorbable intravascular stent. The stent can be degraded in a water bath environment of deionized water at 37 DEG C, 70% of the yarns are broken on the 170th-195th day, and by regulating and controlling the TiO2 deposition thickness on the surface of the monofilament, a lumen is kept smooth and the size is stable about 6 months after the intravascular stent is implanted.

Description

technical field [0001] The invention relates to the technical field of luminal stents, in particular to an absorbable vascular stent and a preparation method thereof. Background technique [0002] Congenital vascular stenosis in children is mostly aortic valve stenosis, which is more harmful and has a high incidence rate in males. It accounts for the sixth place in the incidence of congenital heart disease and can cause developmental disorders, fatigue, and dyspnea. , Fainting, precordial pain, heart failure and other symptoms. Implanting vascular stents in the lesioned part of the large artery to support the stenotic and occluded part of the blood vessel, maintain smooth blood flow, restore blood pressure and reduce the incidence of complications is the main purpose of the treatment of congenital vascular stenosis. [0003] At present, the stents used clinically to treat congenital vascular stenosis diseases are all metal stents, but because the permanent metal stent impla...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/86D04C1/02D04C1/06
CPCA61F2/86D04C1/06D04C1/02A61F2240/002A61F2210/0004
Inventor 孙锟黄臻孙晶李超婧陈笋王映丹白凯武育蓉李元舜孙煦炜柯瑞煜赵鹏军王富军王璐
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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