Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

99results about How to "Low inhibitory concentration" patented technology

Mild shampoo and bath bubbles for infants

The invention discloses mild shampoo and bath bubbles for infants. According to the characteristics of hair and skin of infants, the shampoo and bath bubbles are prepared by selecting disodium cocoyl glutamate, cocamidopropyl betaine and sodium lauryl and glycoside hydroxypropylsulfonate as a surfactant system, selecting camellia-seed oil, alpha-glucan oligosaccharide / inulin compound as a regulating component and selecting flos chrysanthemi indici extract and ethyl lauroyl arginate HCl as a preservative system. The shampoo and bath bubbles are prepared from compatible raw materials, have good cleaning effect and mild and non-irritant performance, and can be used for reinforcing skin barrier to give intimate care to infants.
Owner:金日制药(中国)有限公司

Organosilicon quaternary ammonium long-acting antibacterial product and preparation method thereof

The invention discloses an organosilicon quaternary ammonium long-acting antibacterial product and a preparation method of the organosilicon quaternary ammonium long-acting antibacterial product. The product comprises a first organosilicon quaternary ammonium antibacterial component, a second organosilicon quaternary ammonium antibacterial component and a third synergistic component, wherein the first organosilicon quaternary ammonium antibacterial component is dimethyl alkyl [3-(trimethoxysilyl) propyl] ammonium halide containing C10-C16 alkyl, and the halogen is preferably Cl (chlorine) and Br (bromine); the second organosilicon quaternary ammonium antibacterial component is dimethyl alkyl [3-(trimethoxysilyl) propyl] ammonium halide containing C18-C30 carbon chains, and the halogen is preferably F (fluorine), Cl (chlorine) and I (iodine); the third synergistic component is selected from a group comprising tea polyphenol, aloe and chitosan or a group comprising composition of polyphenol, aloe and chitosan. The antibacterial agent has broad-spectrum antibacterial performance, lasts long, is poisonless, has no irritation to the skin, is especially applicable to sensitive parts of the skin and is a good choice in daily life, wound treatment and operation assistance.
Owner:江西领行生物科技有限公司

3,3'-(3,4-dichlorobenzylidene)-bis-4-hydroxycoumarin and application thereof in preparation of medicine for resisting multi-drug resistant bacteria

The invention discloses a novel compound 3,3'-(3,4-dichlorobenzylidene)-bis-4-hydroxycoumarin with a strong antibacterial effect which is optimized by transforming the structure of bishydroxycoumarin compounds, and provides a preparation method thereof, wherein the chemical structure and crystal structure are obtained. The novel compound 3,3'-(3,4-dichlorobenzylidene)-bis-4-hydroxycoumarin has an antibacterial application value in preparation of a medicine resisting staphylococcus aureus (ATCC29213), methicillin-resistant staphylococcus aureus (MRSA, XJ7502), USA300 (LAC) and vancomycin-resistant staphylococcus aureus (Mu20ATCC700699).
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Preparation method of dual bacteriostatic cinnamyl aldehyde microcapsule

ActiveCN102885379ASolve the problem of excessive volatilizationMask the pungent spicy smellMeat/fish preservation using chemicalsEscherichia coliIrritation
The invention discloses a preparation method of a dual bacteriostatic cinnamyl aldehyde microcapsule, which comprises the following steps of: dissolving chitosan in glacial acetic acid to prepare chitosan solution; adding cellulose and performing enzymolysis reaction to obtain modified chitosan solution; dissolving Arabic gum in water to prepare Arabic gum solution; adding cinnamyl aldehyde, and emulsifying and dispersing at high speed to obtain emulsion; dropwise adding the modified chitosan solution into the emulsion, performing coagulation reaction, adding geniposide, and solidifying; and leaching, drying, and thus obtaining the dual bacteriostatic cinnamyl aldehyde microcapsule. The preparation method has the advantages that cinnamyl aldehyde bacteriostatic component loss is reduced, irritation and spicy of cinnamyl are covered, and cinnamyl aldehyde is slowly released in high-temperature and high-humidity environments; the modified chitosan and cinnamyl aldehyde simultaneously have dual bacteria-resistant effects, and can generate a good bacteria-resistant effect when added into a minced fish product; bacteria-resistant concentration is low, the lowest bacteria-resistant concentration of Escherichia coli can reach 0.10 percent, and the lowest bacteria-resistant concentration of staphylococcus aureus can reach 0.15 percent.
Owner:BOHAI UNIV

Pleuromutilin antibiotic derivatives

The present invention relates to pleuromutilin antibiotic derivatives represented by a general formula (I), pharmaceutically acceptable salts, prodrugs, solvates or stereoisomers thereof, wherein R<2>, Q<1>, Q<2>, m and X are defined in an instruction. The present invention further relates to preparation methods of the compounds, drug compositions containing the compounds, drug preparations containing the compounds, and applications of the compounds in preparation of drugs for treatment and / or prevention of diseases caused by microorganisms.
Owner:KBP BIOSCIENCES CO LTD

Method for rapidly determining drug tolerance of strain

The invention discloses a method for rapidly determining drug tolerance of a strain. The method comprises the following steps: A, preparing nutrient fluid containing methyl thiazolyl tetrazolium; B, preparing bacterial suspension; C, preparing antibiotic solution; D, adding the nutrient fluid containing the methyl thiazolyl tetrazolium, the antibiotic solution and the bacterial suspension into holes of a culture plate, and performing serial dilution on the antibiotic solution; and E, scanning and determining the diluent in real time, and determining the drug tolerance of the strain to antibiotic according to the scanning result. Compared with the prior art, the method has the advantages of simply, rapidly, economically and high-efficiently determining the drug tolerance of the strain.
Owner:CHINESE ACAD OF INSPECTION & QUARANTINE +1

Preparation method of chitosan-g-antibacterial peptide polymer

The invention discloses a preparation method of a novel chitosan-g-antibacterial peptide polymer. The preparation method comprises following steps: at first, synthesizing two amino acid derivatives: lysine-N-carboxylic acid anhydride and valine-N-carboxylic acid anhydride; taking chitosan as a main chain; and grafting a polypeptide chain, which is prepared from lysine-N-carboxylic acid anhydride and valine-N-carboxylic acid anhydride through ring opening polymerization, to the amino groups of chitosan to prepare the chitosan-g-antibacterial peptide polymer. In a neutral medium, the prepared chitosan-g-antibacterial peptide polymer has the advantages of low minimal inhibitory concentration and low minimal bactericidal concentration; at the same time, the synthesis method is simple, the synthesis raw material cost is low, large scale production is easily realized, and due to the antibacterial performance in a neutral medium, the polymer has a high potential application value in the antibacterial field.
Owner:烟台浩忆生物科技有限公司

Chlorhexidine gluconate bath disinfection liquid and preparation method thereof

The present invention relates to a disinfection liquid. The chlorhexidine gluconate bath disinfection liquid comprises, by weight, 1.5-2.5% of CHG, 0.3-1.5% of a compound preservative, 0.5-2.0% of a thickening agent, 2.0-10.0% of a surfactant, 0.5-5.0% of a skin moisturizing agent, 0.5-5.0% of a moisturizing agent, 0.1-2.0% of a penetrant, a proper amount of a pH value regulating agent, and the balance of water. The preparation method comprises: adding a sufficient amount of water to a reaction kettle, heating to a temperature of 50 DEG C, adding the thickening agent under stirring, completely swelling after 30 min, sequentially adding the surfactant, the skin moisturizing agent, the moisturizing agent, the penetrant and the pigment, uniformly mixing, then adding the CHG, stirring for 10 min, cooling to a room temperature, adding the preservative and the essence, stirring for 5 min, adjusting the material liquid to achieve the weak alkaline state, standing, and defoaming. According to the present invention, the CHG can quickly penetrate into the skin stratum corneum and can be adsorbed on the stratum corneum so as to achieve the rapid, complete and durable sterilization purpose.
Owner:SHANGHAI LIKANG DISINFECTION HIGH TECH

Environment-friendly fruit and vegetable preservative paper

The invention relates to the technical field of fresh fruit and vegetable preservation, in particular to environment-friendly fruit and vegetable preservative paper. The environment-friendly fruit and vegetable preservative paper is formed by compounding an upper layer of single-piece wood pulp raw paper and a lower layer of single-piece wood pulp raw paper, wherein the upper-layer paper is bamboo carbon fiber paper; the lower-layer paper is traditional Chinese herbal medicine preservative paper; and the traditional Chinese herbal medicine preservative is formed by spray-coating the raw paper with one to two layers of traditional Chinese herbal medicine preservative liquid. The traditional Chinese herbal medicine components of the raw materials in the preservative liquid have an antibacterial synergistic effect, so the preservative liquid can improve bacteriostatic and preservative effects, is an efficient, broad-spectrum and non-toxic natural fruit and vegetable freshness-retaining preservative and avoids the safety problem of the chemical preservative in the use process. The raw paper is wood pulp paper and bamboo carbon fiber paper, can reduce the humidity of the fruit and vegetable storage space, is antibacterial and anti-mildew, can improve air cleanliness, has an excellent preservative effect, can be used repeatedly, has high degradability and is non-toxic and nuisanceless. The environment-friendly fruit and vegetable preservative paper has a wide application prospect and has an active effect on fruit and vegetable preservation and freshness retaining.
Owner:赵一丞

Anti-tumor application of spiro-three-membered ring and spiro-five-membered ring type peptide deformylase inhibitor

The invention discloses a novel peptide deformylase inhibitor containing spiro-three-membered ring and spiro-five-membered ring types. The novel peptide deformylase inhibitor containing the spiro-three-membered ring and spiro-five-membered ring types has antibacterial activity and anti-tumor activity. The peptide deformylase inhibitor containing the spiro-three-membered ring and spiro-five-membered ring types can serve as a novel antibacterial agent, by inhibiting the activity of peptide deformylase needed in synthesis of bacterium proteins, the novel peptide deformylase inhibitor is effective on multiple antibiotic resistant Gram-positive bacterium strains, the synthesis process of proteins of human bodies is not affected, and accordingly bacteria are killed selectively. The peptide deformylase inhibitor containing the spiro-three-membered ring and spiro-five-membered ring types can further serve as a novel anti-cancer drug; by inhibiting peptide deformylase in mitochondria of cancer cells, energy balance of the cells can be affected, accordingly mitochondrial membranes are depolarized, ATP is used up, and cell apoptosis is promoted; and the novel peptide deformylase inhibitor has good inhibiting activity to multiple cancer cell bacterial strains such as colorectal cancer cell bacterial strains, lung cancer cell bacterial strains, gastric cancer cell bacterial strains and liver cancer cell bacterial strains at the low concentration.
Owner:广东和博制药有限公司

Radix tetrastigme toothpaste and preparation method thereof

The invention discloses a trefoil toothpaste and a preparation method thereof. The toothpaste is calculated in parts by weight: it includes 3.4-17.8 parts of a mixed wall-broken stock solution and toothpaste paste bases such as xanthan gum and carrageenan; the mixed wall-broken stock solution consists of three Composition of Yeqing, green tea leaves and Panax notoginseng, the weight of the three is 3-15 parts of Sanye Qingxian, 0.3-2 parts of green tea leaves, and 0.1-0.8 parts of Sanqi. The toothpaste uses spectrum sterilization and ultra-low constant temperature vibration The mixed wall-breaking stock solution is obtained by breaking the wall and micro-grinding, and the cell wall-breaking rate is over 98.5%. At the same time, under the condition of temperature control, it is combined with the toothpaste paste matrix. The micro-grinding method can obtain the mixed wall-broken stock solution with the best medicinal properties under controlled temperature conditions, and make it fully integrated into the toothpaste, which not only improves the utilization rate of medicinal materials and increases their added value, but also has a good effect on oral ulcers, periodontitis, and gums. Oral diseases such as bleeding are better than general drug toothpaste, which is more conducive to dental health.
Owner:NINGBO SHENGWANG BIOTECH CO LTD

Amido pyrimidine compound

The invention provides an amido pyrimidine compound with a novel structure as shown in a formula (I) and a preparation method and application of the amido pyrimidine compound. The amido pyrimidine compound is a compound shown as the formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer or tautomer thereof and the like. The amido pyrimidine compound provided bythe invention has a relatively good proliferation inhibition effect on various cancer cells; according to the present invention, the compound has characteristics of low tumor cell inhibition concentration, significantly-improved compound activity, good tumor cell selectivity and good solubility, and is expected to be a specific drug for treatment of malignant tumor cell abnormal proliferation diseases caused by EGFR mutation.
Owner:LUNAN PHARMA GROUP CORPORATION

Pharmaceutical composition for treating bacterial dairy cow mastitis and preparation method thereof

The invention discloses a pharmaceutical composition for treating bacterial dairy cow mastitis. The pharmaceutical composition is prepared from the following raw materials: N-acetylcysteine, ampicillin, polyethylene glycol 400 and polyethylene glycol 4000; the invention further provides a preparation method of the pharmaceutical composition. The pharmaceutical composition has the beneficial effects that a preparation process is simple; the pharmaceutical composition is convenient to use in clinic; after the N-acetylcysteine and the ampicillin are compounded, the minimal inhibitory concentration of the ampicillin for main pathogenic bacteria, including escherichia coli, staphylococcus aureus, streptococcus agalactiae and streptococcus dysgalactiae, of the dairy cow mastitis can be remarkably reduced when being compared with that of single utilization of the ampicillin, so that the bacterium inhibition or bacterium killing effect of the ampicillin on the pathogenic bacteria is enhanced, and the pharmaceutical composition has a remarkable treatment effect on the dairy cow mastitis caused by the pathogenic bacteria; the pharmaceutical composition adopts a paste preparation and is injected into mammary chambers of dairy cows with the mastitis through a teat canal, so that the pathogenic bacteria can be rapidly killed; meanwhile, the pathogenic bacteria in the environment can be prevented from entering the mammary chambers and a prevention effect is realized; the pharmaceutical composition is easily absorbed and breast tissues of the dairy cows with the mastitis are not injured.
Owner:LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS

Nano-material antibacterial health care protection pad for women

The invention discloses a nano-material antibacterial health care protection pad for women and belongs to the technical field of sanitation supplies. The protection pad comprises a net face layer, a traditional Chinese medicine layer, a water absorption layer, a waterproof layer and an adhesive layer which are laminated from top to bottom in sequence, and the net face layer is nano-silver antibacterial non-woven fabric which is soaked in a traditional Chinese medicine immersion solution and dried and comprises the following components including nano-silver, 5,5-dimethylhydantoin, chitosan, eggshell powder, polyethylene, ES fibers and negative ion fibers; the traditional Chinese medicine immersion solution is extracted from the following traditional Chinese medicine raw materials includingangelica sinensis, rhizoma cyperi, honeysuckle, dandelions, folium artemisiae argyi, dried fructus crataegi and medicated leaven, dried lumbricus and motherwort; the traditional Chinese medicine layercomprises the following medicine including saffron crocus, common cnidium fruits, fructus forsythia, houttuynia cordata, belvedere fruits, rhizoma coptidis, radix sophorae flavescentis, angelica sinensis and radix bupleuri. By adopting a reinforcement system composed of 5,5-dimethylhydantoin, chitosan and polyethylene, the antibacterial performance of the protection pad for women is improved.
Owner:CHANGSHA XIAORU INFORMATION TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products