Organosilicon quaternary ammonium long-acting antibacterial product and preparation method thereof

Abstract

The invention discloses an organosilicon quaternary ammonium long-acting antibacterial product and a preparation method of the organosilicon quaternary ammonium long-acting antibacterial product. The product comprises a first organosilicon quaternary ammonium antibacterial component, a second organosilicon quaternary ammonium antibacterial component and a third synergistic component, wherein the first organosilicon quaternary ammonium antibacterial component is dimethyl alkyl [3-(trimethoxysilyl) propyl] ammonium halide containing C10-C16 alkyl, and the halogen is preferably Cl (chlorine) and Br (bromine); the second organosilicon quaternary ammonium antibacterial component is dimethyl alkyl [3-(trimethoxysilyl) propyl] ammonium halide containing C18-C30 carbon chains, and the halogen is preferably F (fluorine), Cl (chlorine) and I (iodine); the third synergistic component is selected from a group comprising tea polyphenol, aloe and chitosan or a group comprising composition of polyphenol, aloe and chitosan. The antibacterial agent has broad-spectrum antibacterial performance, lasts long, is poisonless, has no irritation to the skin, is especially applicable to sensitive parts of the skin and is a good choice in daily life, wound treatment and operation assistance.

Description

technical field [0001] The invention relates to the field of antibacterial agents, in particular the invention relates to a long-acting antibacterial product containing organosilicon quaternary ammonium salt and a preparation method thereof. Background technique [0002] Bacteria have been one of the major threats to human health, and for centuries people have tried to kill the bad bacteria and encourage the growth of the good ones. The antibacterial agents currently used in the market mainly include three categories: inorganic antibacterial agents, organic antibacterial agents and natural antibacterial agents. Inorganic antibacterial agents mainly include metal ion type and photocatalytic type. Metal ion type includes silver series, zinc series and copper series. Through physical adsorption, ion exchange and other methods, silver, copper, zinc and other metals (or metal ions) ) is fixed on the surface of porous materials such as fluorspar and silica gel to make antibacteri...

AI Technical Summary

Problems solved by technology

[0003] All these antibacterial agents have defects in varying degrees during use: the cost of inorganic antibacterial agents is high, and the antibacterial effect is slow; organic antibacterial agents are often irritating to the skin, have low safety, and poor antibacterial durability; natural antibacterial agents The agent has poor broad-spectrum and is unstable to light, heat and chemicals

Such as U.S. Patent US6613755, it is proposed to use ultra-pure water as the medium, and the purity resistivity of water is required to reach more than 18 megohm centimeters, so that a stable silane quaternary ammonium salt solution can be obtained, and various stable disinfectant hand sanitizers and facial cleansers can be made. etc., but the preparation of ultrapure water requires high equipment, and it is difficult for domestically produced pure water for the electronics industry to reach a resistivity of 18 megohm cm, and ultrapure water has high requirements for packaging containers and the surrounding environment, which is difficult practical

US6087319 adopts adding a large amount of propylene glycol ether, alkyl quaternary ammonium salt and acrylic surfactant in water to obtain a stable aqueous solution, but the cost is relatively increased, and there is no guarantee for antibacterial effect and washability

Another example is that US662172 adopts propylene carbonate and ethylene glycol butyl ether as a solvent, and then adds water to obtain a stable aqueous solution, but how long it can be stored is not specified, and propylene carbonate and ethylene glycol butyl ether are used in a large amount, and the cost is high

[0006] Another defect of organosilicon quaternary ammonium salts is poor antibacterial effect, such as 3-(trialkoxysilyl) propyl octadecyl dimethyl ammonium chloride has a relatively high antibacterial concentration, because siloxane The minimum inhibitory concentration of the shielding effect is above 200PPM, that is, the dosage is relatively large. Generally, the minimum inhibitory concentration of non-silicon antibacterial agents is several to dozens of PPM

This has led to the need to use a larger amount to achieve the effect of sterilization and bacteriostasis

[0007] The use of a large number of antibacterial ingredients, on the one hand, will significantly increase the cost, on the other hand, it will greatly reduce its own advantages of non-irritating to the skin, and even cause the risk of allergies

Another problem with high minimum inhibitory concentration is repeated medication, which is always inconvenient for the fast-paced life of modern society and specific wounds

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