Pharmaceutical composition for treating bacterial dairy cow mastitis and preparation method thereof

Abstract

The invention discloses a pharmaceutical composition for treating bacterial dairy cow mastitis. The pharmaceutical composition is prepared from the following raw materials: N-acetylcysteine, ampicillin, polyethylene glycol 400 and polyethylene glycol 4000; the invention further provides a preparation method of the pharmaceutical composition. The pharmaceutical composition has the beneficial effects that a preparation process is simple; the pharmaceutical composition is convenient to use in clinic; after the N-acetylcysteine and the ampicillin are compounded, the minimal inhibitory concentration of the ampicillin for main pathogenic bacteria, including escherichia coli, staphylococcus aureus, streptococcus agalactiae and streptococcus dysgalactiae, of the dairy cow mastitis can be remarkably reduced when being compared with that of single utilization of the ampicillin, so that the bacterium inhibition or bacterium killing effect of the ampicillin on the pathogenic bacteria is enhanced, and the pharmaceutical composition has a remarkable treatment effect on the dairy cow mastitis caused by the pathogenic bacteria; the pharmaceutical composition adopts a paste preparation and is injected into mammary chambers of dairy cows with the mastitis through a teat canal, so that the pathogenic bacteria can be rapidly killed; meanwhile, the pathogenic bacteria in the environment can be prevented from entering the mammary chambers and a prevention effect is realized; the pharmaceutical composition is easily absorbed and breast tissues of the dairy cows with the mastitis are not injured.

Description

technical field [0001] The invention relates to the technical field of veterinary pharmaceutical compositions, in particular to a pharmaceutical composition for treating bacterial cow mastitis and a preparation method thereof. Background technique [0002] Cow mastitis is the most common and harmful disease in the dairy industry. my country is a big dairy farming country, and the overall incidence of mastitis in dairy cows is higher than the world average, which restricts the development of dairy related industries. Pathogenic microorganisms are the main cause of mastitis. Among them, Escherichia coli, Staphylococcus aureus, Streptococcus agalactiae and Streptococcus dysgalactia are the main infectious bacteria that cause mastitis in dairy cows, and the infections caused by them account for the largest proportion of mastitis in cows. More than 50% of the total incidence. [0003] Antibiotics are the first choice for the treatment of subclinical mastitis in dairy cows. Amo...

AI Technical Summary

Problems solved by technology

In the prior art, the treatment drugs for cow mastitis mainly rely on the bactericidal effect of single or multiple antibiotics. Clinically, long-term use of this drug will promote the horizontal transfer of drug-resistant factors in bacteria and accelerate the evolution of drug-resistant strains, which is not conducive to Long-term and effective control of cow mastitis

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