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Chlorhexidine gluconate bath disinfection liquid and preparation method thereof

A technology of chlorhexidine gluconate and disinfectant, which is applied in the field of disinfectant, can solve problems such as pollution and inability to completely kill bacteria, and achieve the effects of increasing diffusivity, changing skin permeability, and enhancing transdermal absorption

Inactive Publication Date: 2015-07-01
SHANGHAI LIKANG DISINFECTION HIGH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the skin disinfection immediately before the operation cannot completely kill all bacteria, the only way to reduce the amount of bacteria on the skin is to take a bath before the operation. In addition, if you do not take a bath before the operation, direct pollution may also occur during the operation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0020] Example 1: CHG 2.0, chlorobutanol 0.3 and benzalkonium chloride 0.1, xanthan gum 0.6, alkyl glycoside 5.0, water-soluble simethicone 1.0, lanolin polyoxyethylene ether 0.5, glycerol 2.0 , lavender essence 0.1, sorbitol 0.8, carmine food coloring 0.01, sodium carbonate 0.1-0.5, and the rest is water.

example 2

[0021] Example 2: CHG 2.0, chlorocresol 0.05 and phenylethyl alcohol 0.5, gum arabic 0.6, Tween-80 3.0, water-soluble simethicone 1.0, lanolin polyoxyethylene ether 0.5, propylene glycol 2.0, lavender essence 0.1 , sorbitol 0.8, carmine food coloring 0.01, sodium carbonate 0.1-0.5, and the rest is water.

example 3

[0022] Example 3: CHG 2.0, hydantoin 0.2 and benzyl alcohol 0.5, carmellose sodium 0.6, alkyl glycoside 5.0, water-soluble simethicone 1.0, lanolin polyoxyethylene ether 0.5, glycerin 2.0 , lavender essence 0.1, mannitol 0.5, carmine food coloring 0.01, sodium carbonate 0.1-0.5, and the rest is water.

[0023] According to the formula of the above example, add a sufficient amount of water into the reaction kettle, heat up to 50°C, add the thickener under stirring, wait for 30 minutes for it to swell completely, and then add the surfactant and emollient in sequence , humectant, penetrant, pigment, mix well, then add CHG, stir for 10 minutes, when the feed liquid in the reaction kettle drops to room temperature, add preservatives, essence, stir for 5 minutes, then adjust the feed liquid to pH with appropriate amount of sodium carbonate The value is weakly alkaline, and it will defoam when left standing.

[0024] Bactericidal effect

[0025] The comparison of table 1 common ski...

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PUM

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Abstract

The present invention relates to a disinfection liquid. The chlorhexidine gluconate bath disinfection liquid comprises, by weight, 1.5-2.5% of CHG, 0.3-1.5% of a compound preservative, 0.5-2.0% of a thickening agent, 2.0-10.0% of a surfactant, 0.5-5.0% of a skin moisturizing agent, 0.5-5.0% of a moisturizing agent, 0.1-2.0% of a penetrant, a proper amount of a pH value regulating agent, and the balance of water. The preparation method comprises: adding a sufficient amount of water to a reaction kettle, heating to a temperature of 50 DEG C, adding the thickening agent under stirring, completely swelling after 30 min, sequentially adding the surfactant, the skin moisturizing agent, the moisturizing agent, the penetrant and the pigment, uniformly mixing, then adding the CHG, stirring for 10 min, cooling to a room temperature, adding the preservative and the essence, stirring for 5 min, adjusting the material liquid to achieve the weak alkaline state, standing, and defoaming. According to the present invention, the CHG can quickly penetrate into the skin stratum corneum and can be adsorbed on the stratum corneum so as to achieve the rapid, complete and durable sterilization purpose.

Description

technical field [0001] The invention relates to a disinfectant, in particular to a rinse-free bath disinfectant. Background technique [0002] The Ministry of Health issued the "Administrative Measures for Antimicrobial Drugs in Medical Institutions" in 2011, which stipulates that prophylactic drugs should be used 30 minutes to 2 hours before surgery, and the course of treatment should not exceed 24 hours. It is required that the proportion of prophylactic use of antibiotics for patients undergoing type I incision surgery should not exceed 30%, and the time should not exceed 24 hours, that is, 70% of type I incision operations cannot use antibiotics. If a medical institution "fails the antimicrobial drug application assessment" in the supervision and assessment, it will be downgraded or downgraded. Because the skin disinfection immediately before the operation cannot completely kill all bacteria, the only way to reduce the amount of bacteria on the skin is to take a bath be...

Claims

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Application Information

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IPC IPC(8): A61K8/89A61K8/92A61K8/60A61Q19/10A61P31/02
Inventor 张忠敏邹贤信李靖
Owner SHANGHAI LIKANG DISINFECTION HIGH TECH
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