206 results about "Chlorhexidine gluconate" patented technology

Toothpaste incorporating chlorhexidine bigluconate for improved adhesive onto the surface of the teeth. A second embodiment discusses the use of triclosan and in combination with sodium monofluorphosphate for use in the toothpaste.

Pharmaceutical dental gel preparation comprising of metronidazole benzoate, chlorhexidine gluconate, and local anesthetic as the active ingredient; glycol as the solvent medium; a carboxyvinyl polymer, cross-linked polymer of acrylic acid copolymerized with polyalkylsucrose as a gelling agent.

The invention relates to a silicone catheter including chlorhexidine gluconate, methods of making this catheter, and methods of using it. The method of making the catheter includes contacting a silicone catheter with a liquid containing chlorhexidine gluconate. Chlorhexidine gluconate is stably incorporated into the silicone catheter.The invention also relates to a silicone medical device or article including chlorhexidine gluconate and methods of making this such a medical device or article.

Antimicrobial compositions are provided that include a hydroalcoholic solvent system comprising a lower C2-C5 alcohol and water; a cationic antimicrobial agent such as chlorhexidine gluconate; a fatty component containing at least one free hydroxyl group, such as a C12-C21 fatty alcohol, a C12-C21 fatty ester, a C12-C21 fatty ether, a C12-C21 fatty amide, and combinations thereof; and optionally an emollient ester such as diesters of bibasic acids and triesters of citric acid. The compositions described herein display improved antimicrobial efficacy and improved cosmetic elegance.

A pharmaceutical dental formulation of therapeutically effective amounts of metronidazole benzoate and chlorhexidine gluconate is described. The formulation also includes a gelled hydrophilic and water-dipersible polymer having free carboxylic groups, an aqueous base, a penetration enhancer and a chelating agent. The formulation is for topical application in the form of an aqueous gel in the treatment of periodontal diseases including gingivitis, stomatitis, Apthous ulcers and post-extraction infection.

Antimicrobial compositions are provided that include a hydroalcoholic solvent system comprising a lower C2-C5 alcohol and water; a cationic antimicrobial agent such as chlorhexidine gluconate; a fatty component containing at least one free hydroxyl group, such as a C12-C21 fatty alcohol, a C12-C21 fatty ester, a C12-C21 fatty ether, a C12-C21 fatty amide, and combinations thereof; and optionally an emollient ester such as diesters of bibasic acids and triesters of citric acid. The compositions described herein display improved antimicrobial efficacy and improved cosmetic elegance.

Antimicrobial compositions are provided that include a hydroalcoholic solvent system comprising a lower C2-C5 alcohol and water; a cationic antimicrobial agent such as chlorhexidine gluconate; a hydrophobic polymer soluble in the lower alcohol; an emollient ester such as diesters of bibasic acids and triesters of citric acid; and an optional fatty component containing at least one free hydroxyl group, such as a C12-C21 fatty alcohol, a C12-C21 fatty ester, a C12-C21 fatty ether, a C12-C21 fatty amide, and combinations thereof. The compositions described herein display improved antimicrobial efficacy and improved cosmetic elegance.

The invention discloses methods of making and uses for wide spectrum disinfectants including as components an alcohol, O-phenylphenol, chlorhexidine gluconate, nonoxynol-9, benzalkonium chloride, and deionised double distilled water wherein on a weight / volume ratio the alcohol comprises from 50 to 80%, the O-phenylphenol comprises from 0.1% to 0.8%, the chlorhexidine gluconate comprises from 0.01 to 1%, the nonoxynol-9 comprises from 0.02 to 1%, and the benzalkonium chloride comprises from 0.15 to 1%.

A disinfectant delivery system and method of providing alcohol-free disinfection to a body to be disinfected, as well as a method of infection reduction by preparation of a patient before an invasive procedure. A blended cloth comprising first fibers and second fibers is provided with the first fibers generally being greater in quantity by weight than the second fibers. A disinfectant solution impregnates the blended cloth, with the disinfectant solution having chlorhexidine gluconate as an active ingredient and having no alcohol. In the method according to the invention, at least one impregnated blended cloth is used to disinfect at least a portion of a body. A plurality of blended cloths can be provided for disinfecting discrete portions of the body. When an invasive procedure is to be performed on a patient, a further method according to the invention of infection reduction comprises using a CHG-impregnated cloth to disinfect at least a portion of the patient at least one day prior to the invasive procedure proximate the location of the invasive procedure.

An antimicrobial composition, generally comprising a biocidal agent, such as chlorhexidine gluconate, a lubricant, such as a modified siloxane, and a solvent, such as an alcohol and / or water. The biocidal agent acts as a highly effective biocide while the lubricant reduces friction between various components of a medical device during assembly. The antimicrobial composition may be applied to an internal component of the medical device prior to assembly. The process of assembling the medical device results in antimicrobial composition being distributed to various internal structures and geometries of the medical device as the coated, internal component is assembled into the interior of the medical device. Air is then used to further distribute excess antimicrobial agent to the remaining surfaces downstream from the installed, internal component. In some embodiments, additional air is passed through the assembled medical device to assist in removing the carrier solvent from the medical device via evaporation.

The invention provides mouth wash for oral hygiene and health care. The mouth wash for oral hygiene and health care comprises the following components in percentage by weight: 0.2-2% of small molecular active peptide, 5-15% of glycerinum, 0.5-2% of hydrogenated castor oil, 0.05-0.5% of chlorhexidine gluconate, 2.5-10% of xylitol, 0.1-0.3% of potassium sorbate, 0.01-0.03% of sucralose, 0.025-0.1% of menthol, 0.025-0.1% of sweet orange essence, 1-15% of ethanol and the balance of distilled water. The mouth wash provided by the invention has the bacteriostatic and cleaning effect on human oral cavities; in addition, the small molecular active peptide is uses together with chlorhexidine gluconate, so that the mouth wash has the effects of resisting inflammations, accelerating repair of oral mucosa, treating dental ulcer and the like.

The invention provides a new primary culture method for liver cells of crucian carp, which mainly comprises the following steps: a, separating liver tissues from crucian carp; b, digesting cut liver tissues by using a stepwise digestion process and obtaining inner cell mass; and c, purifying and culturing obtained inner cell mass. In the method disclosed by the invention, the raw material is obtained from common crucian carp aquatic experimental animals, in-vitro tissue blocks are soaked in chlorhexidine gluconate (chlorhexidine) to be disinfected for reducing pollution. The tissues are digested by a stepwise digestion process, blood cell lysing solution is used to reduce the blood cell content in cells, and the liver cells are purified by percoll gradient centrifugation. The liver cells are purified by combined material preparation, the stepwise digestion process, blood cell lysing solution and percoll. The method can culture adequate liver cells, the survival rate of the liver cellsis over 90 percent, and the method meets requirements of primary culture.

The invention discloses a hand disinfecting wet tissue convenient to carry, which consists of non-woven fabric and wet tissue liquor. The wet tissue liquor consists of glycerol, chlorhexidine gluconate, triclosan, ethanol, aloe extract, methylparaben, ethylene diamine tetraacetic acid, essence and purified water. The hand disinfecting wet tissue not only has a disinfecting performance, but also is added with skin care contents, and does not injure the skin of a user while disinfecting. The hand disinfecting wet tissue belongs to an alcohol-water system, is fresh, cool and not oily, is added with chlorhexidine gluconate and triclosan disinfecting contents, effectively kills bacteria of hands of the user, does not have any odor of disinfectant, is added with the skin care agent glycerol and the aloe extract, and effectively protects the skin of the user. Each package holds a piece of hand disinfecting wet tissue, the hand disinfecting wet tissue is clean and sanitary in use, is disposable, cannot be polluted even the wet tissue is used repeatedly, is easy to carry, and also can be used for disinfecting hands of workers in cosmetics and medicine production workshops.

The present invention provides a germicidal antiseptic composition for dilution, which is superior in preparation stability, and free of formation of insoluble precipitation even when diluted with water containing an inorganic ion (e.g., tap water etc) when in use, thereby retaining superior germicidal disinfection ability. The present invention relates to a germicidal antiseptic composition for dilution, which is an aqueous liquid comprising chlorhexidine gluconate as a main ingredient, (1) 1-10 w / v % of chlorhexidine gluconate; (2) 1-10 w / v % of one or more selected from the group consisting of a polyoxyethylene alkyl ether and a polyoxyethylene alkenyl ether, each having an HLB of 10-15 and a congeal point of not more than 35° C.; (3) 0.001-0.5 w / v % of a water-soluble organic monocarboxylic acid having 2 to 6 carbon atoms; and (4) water.

Devices, coating compositions and methods for making such compositions are provided, wherein the coatings deliver chlorhexidine gluconate from a stable non-aqueous system.

The invention discloses a formula for non-clean disinfectant with skin protection effects and a method for preparing the non-clean disinfectant. The non-clean disinfectant in the formula comprises, by weight, 0.1%-1.0% of thickening agents, 0.1%-10.0% of disinfectants, 20.0%-40.0% of solubilizing assistants, 10.0%-20.0% of inclusion agents, 0.2%-2.0% of neutralizers, 1.0%-10.0% of humectants, 1.0%-10.0% of skin protectants, 0.2%-2.0% of essence and the balance deionized water. The formula and the method have the advantages that the problem that anions and cations cannot coexist is solved, and carbomer which is an anionic thickening agent and chlorhexidine gluconate which is a cationic disinfectant can coexist in the same system; moisturizing and skin protection effects of the non-clean disinfectant are additionally realized, and accordingly the skins of the hands of users can be nourished, not only can be disinfected, but also can be protected and can be protected on the basis of disinfection; the sterilization capacity can be reinforced, antibacterial effects can be continuously realized, and accordingly infection can be prevented; pungent smell of disinfection components can be reduced, and accordingly the non-clean disinfectant smells fresh and can be easily accepted by the public; the non-clean disinfectant is portable and is convenient to use and suitable for the public, and the skins of the hands of the users can be disinfected by the aid of the non-clean disinfectant at any time in any places.

The invention discloses methods of making and uses for wide spectrum disinfectants including as components an alcohol, O-phenylphenol, chlorhexidine gluconate, nonoxynol-9, benzalkonium chloride, and deionised double distilled water wherein on a weight / volume ratio the alcohol comprises from 50 to 80%, the O-phenylphenol comprises from 0.1% to 0.8%, the chlorhexidine gluconate comprises from 0.01 to 1%, the nonoxynol-9 comprises from 0.02 to 1%, and the benzalkonium chloride comprises from 0.15 to 1%.

The invention provides pubes-cleaning disinfection nursing liquid used for the pudendum and the vagina of a human body, which consists of 'chlorhexidine acetate (or chlorhexidine gluconate), borneol and osthole' added with a proper amount of synergist and the balance of distilled water, wherein the pH value is adjusted to be 4 to 5 by a pH balance factor. The product can kill pathogenic bacteria of HIV, neisseria gonorrhoeae, staphylococcus aureus, escherichia coli, candida albicans and the like and other viruses in one minutes so as to block cross infections of various infectious diseases, eliminate smells and relieve itching.

The invention provides a multi-purpose disinfectant, which is mainly applied to skin, surfaces of the wound and mucous membranes, surfaces of common articles and textile, and the like. The disinfectant consists of the following raw materials: single and double chain compound quaternary ammonium salt, chlorhexidine acetat(or chlorhexidine gluconate) and proper amount of synergistic agent and distilled water. The disinfectant can quickly kill enteric bacilli, suppurative bacilli, yeast bacteria, hospital infection common bacteria, and all known common bacteria, and is widely applied to fields in medical treatment, industry, civilian use and the like.

The invention provides an odor-removing care solution, a preparation method thereof and an odor-removing sanitary towel and relates to the field of sanitation supplies. The odor-removing care solutioncontains the following components in parts by mass: 0.2-2 parts of Ectoine, 0.5-5 parts of 4-ethyl-4-soybase ethyl sulfate morpholine, 0.1-2 parts of dipotassium glycyrrhizinate, 0.1-2 parts of sodium benzoate, 1-5 parts of phenoxyethanol, 0.1-1 part of grapefruit extract, 1-4 parts of chlorhexidine gluconate, 20-50 parts of ethanol and 20-50 parts of water. The odor-removing care solution can achieve effects of effectively removing odor and effectively preventing bacterium growth on the surface of the sanitary towel. The preparation method of the odor-removing care solution comprises a stepof uniformly mixing the previous components, and is simple in operation and easy to realize. The prepared odor-removing care solution is capable of effectively removing odor and preventing odor spreading. The odor-removing sanitary towel is prepared by spraying the odor-removing care solution onto the surface of the sanitary towel, and can achieve effects of effectively removing odor and preventing odor spreading.

The invention discloses chlorhexidine gluconate gargle, which contains the following components in part by weight: 0.08 to 1.2 parts of chlorhexidine gluconate, 50 to 100 parts of propylene glycol, 50 to 100 parts of glycerol and 1 to 5 parts of polyoxyethylene 40 hydrogenated castor oil. The chlorhexidine gluconate gargle has a simple formula, a simplified process and stable quality.

A non-toxic mucosal disinfectant for topical application in the nose has a composition of 91% isopropyl alcohol of at least 50% by weight; sesame oil not exceeding 45% by weight, lemon oil of about 2% by weight, aloe of about 5-10% by weight, and optional components of chlorhexidine gluconate and grapefruit seed extract. All of the components are mixed homogeneously, with the sesame oil supplementing and neutralizing the dehydrating effect of the alcohol.

Antimicrobial compositions are provided that include a hydroalcoholic solvent system comprising a lower C2-C5 alcohol and water; a cationic antimicrobial agent such as chlorhexidine gluconate; a hydrophobic polymer soluble in the lower alcohol; an emollient ester such as diesters of bibasic acids and triesters of citric acid; and an optional fatty component containing at least one free hydroxyl group, such as a C12-C21 fatty alcohol, a C12-C21 fatty ester, a C12-C21 fatty ether, a C12-C21 fatty amide, and combinations thereof. The compositions described herein display improved antimicrobial efficacy and improved cosmetic elegance.

A catheter configured for partial implantation into a patient and drainage of a body cavity may be provided with microtextured surface on one or more inner diameter surfaces and / or outer diameter surfaces of the tubular catheter body. The microtexturing may include surface features dimensioned to inhibit colonization and / or migration of microbes. The microtexturing may also include channels or other recesses containing an antimicrobial agent such as chlorhexidine gluconate or any other effective antimicrobial agent.

The invention discloses a wound antibiotic flushing fluid and a preparation method thereof. Counted by 100 ml of wound antibiotic flushing fluid, the the formula of the wound antibiotic flushing fluid comprises the following raw materials: 0.01-2 g of chlorhexidine salt, 3-1,000 micrograms of silver nitrate, 10-70ml of absolute ethyl alcohol, 5-20 ml of emollient, 0.5-5g of thickening agent, 0.05-5g of tween 80, 0.5-5g of pH adjusting agent and 20-90ml of deonized water, wherein the chlorhexidine salt is chlorhexidine acetate or chlorhexidine gluconate; and the emollient is glycerol. The preparation method comprises the following steps of: dissolving the thickening agent in the deonized water, then respectively adding the chlorhexidine salt, the silver nitrate, the absolute ethyl alcohol, the emollient, the tween 80 and the pH adjusting agent into the mixed solution and stirring for 30 minutes to 2 hours. The wound antibiotic flushing fluid contains various antibiotic components and considerably strong broad spectrum bacteriostasis and sterilization functions, can kill various bacterial and fungus and has constant antibacterial action.

Provided herein is a composition and a method for removing CHG from textiles. The composition is an acid-surfactant-based composition that may be used to remove CHG from a textile that has not been exposed to chlorine subsequent to being exposed to CHG.

A synergistic pharmaceutical composition for the preparation of topical formulations for use in prophylaxis and treatment of wounds, burn wounds, skin grafts, pressure ulcers, diabetic foot ulcers and other skin diseases is provided. The composition may include one or more synergistically active ingredients and one or more inactive ingredients. The synergistically active ingredients may include Recombinant Human Epidermal Growth Factor (rh-EGF) (REGEN-D™ of Bharat Biotech International Limited) and / or Platelet Derived Growth Factor (rh-PDGF-BB), silver sulfadiazine (SSD) and chlorhexidine gluconate (CHG). One or more inactive ingredients may comprise carriers, preservatives, emulsifiers, skin emollients and soothers and one or more other constituents.

The invention discloses a quick-drying surgical hand disinfection solution and a preparation method of the quick-drying surgical hand disinfection solution. The quick-drying surgical hand disinfection solution mainly comprises bactericidal compositions and purified water, wherein the bactericidal compositions comprise the following raw materials which are taken as constituents: organosilicon quaternary ammonium salt, Chlorhexidine gluconate, ethanol and glycerol. The preparation method of the quick-drying surgical hand disinfection solution comprises the following steps: adding ethanol in a mixing tank, then adding the organosilicon quaternary ammonium salt, Chlorhexidine gluconate and glycerol and simultaneously stirring to be completely dissolved, then adding purified water to be diluted, and adding a pH (Potential of Hydrogen) regulator to adjust the pH value to 5.5 to 7.5 to obtain the quick-drying surgical hand disinfection solution. The disinfection solution disclosed by the invention solves the defects of slow bactericidal effect of Chlorhexidine gluconate and weak sterilization of ethanol, reaches quick disinfection and sterilization and a long-lasting antibacterial effect, can effectively protect human skin by adding glycerol, has small skin irritation, no harm to human health, convenient use, easily obtained raw materials, simple formula, suitability for industrial production and capability of being used for surgical hand washing disinfection, hygiene hand washing disinfection and daily hand disinfection.

The invention provides a method for simultaneously measuring the contents of multiple skin disinfectants in the wet tissue, and aims at providing the method which has simple operating method for simultaneously measuring the contents of multiple skin disinfectants in the wet tissue. The method uses a high performance liquid chromatography method to simultaneously measure the contents of chlorhexidine gluconate, chlorhexidine acetate, 2,4,4'-trichlorine-2'-phenoxyphenol, benzalkonium bromide, benzalkonium chloride and glutaraldehyde in the wet tissue. The invention belongs to the technical field of chemical detection.