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Chlorhexidine gluconate gargle

A technology of chlorhexidine gluconate and gargle, which is applied in the field of medicine and can solve the problems of poor stability, easy deterioration and discoloration, etc.

Active Publication Date: 2012-02-01
重庆健能医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the chlorhexidine gluconate gargle is used for oral gargle, the mouthfeel is very important to the patient's medication compliance. Therefore, the adjustment of the mouthfeel in the prescription research, that is, the screening research of the flavoring agent and its dosage will be a difficult point; The raw material chlorhexidine gluconate is sensitive to light. Under the condition of light exposure, the stability is not good, and it is easy to deteriorate and change color. Most of the chlorhexidine gluconate preparations on the market in China now have the problem of poor stability.

Method used

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  • Chlorhexidine gluconate gargle
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1. Prescription:

[0016] Chlorhexidine gluconate solution (calculated as chlorhexidine gluconate) 1.2g

[0017] Propylene glycol 50g

[0018] Glycerin 50g

[0019] Polyoxyethylene (40) hydrogenated castor oil 1g

[0020] Purified water up to 1000ml

[0021] 2. Process steps:

[0022] (1) Get the propylene glycol of recipe quantity and add in the container, then add polyoxyethylene 40 hydrogenated castor oil, fully stir to make it dissolve completely, obtain solution 1;

[0023] (2) Add a full amount of 60% purified water in the liquid preparation tank, add the prescribed amount of chlorhexidine gluconate solution and glycerin, stir and dissolve to obtain solution 2;

[0024] (3) Said that solution 1 was added into the liquid mixing tank, added purified water to make up to full volume, stirred and mixed to obtain the intermediate;

[0025] (4) Intermediate detection (detection indicators: traits, pH value, content);

[0026] (5) Filtration and filling: filter wit...

Embodiment 2

[0028] 1. Prescription:

[0029] Chlorhexidine gluconate solution (calculated as chlorhexidine gluconate) 1.2g

[0030] Propylene glycol 50g

[0031] Glycerin 50g

[0032] Polyoxyethylene (40) hydrogenated castor oil 1g

[0033] Peppermint essence 1ml

[0034] Protein sugar 0.2g

[0035] Allura Red 0.01g

[0036] 0.1mol / L HCl or 0.1mol / L NaOH appropriate amount

[0037] Purified water up to 1000ml

[0038] 2. Process steps:

[0039] (1) Weigh the propylene glycol of prescription quantity and add in the container, then add polyoxyethylene 40 hydrogenated castor oil, peppermint essence, fully stir to make it dissolve completely, obtain solution 1;

[0040] (2) Add 60% of the total amount of purified water in the liquid preparation tank, add the prescribed amount of chlorhexidine gluconate solution, glycerin, protein sugar and allura red, stir and dissolve to obtain solution 2;

[0041] (3) Add solution 1 into the liquid mixing tank, add purified water to make up to full...

Embodiment 3

[0046] 1. Prescription:

[0047] Chlorhexidine gluconate solution (calculated as chlorhexidine gluconate) 0.08g

[0048] Propylene glycol 100g

[0049] Glycerin 50g

[0050] Polyoxyethylene (40) hydrogenated castor oil 1g

[0051] Peppermint essence 1ml

[0052] Protein sugar 0.2g

[0053] Allura Red 0.01g

[0054] 0.1mol / L HCl or 0.1mol / L NaOH appropriate amount

[0055] Purified water up to 1000ml

[0056] 2. Process steps:

[0057] (1) Weigh the propylene glycol of prescription quantity and add in the container, then add polyoxyethylene 40 hydrogenated castor oil, peppermint essence, fully stir to make it dissolve completely, obtain solution 1;

[0058] (2) Add a full amount of 60% purified water into the liquid preparation tank, add the prescribed amount of chlorhexidine gluconate solution, glycerin, protein sugar and allura red, stir and dissolve to obtain solution 2;

[0059] (3) Add solution 1 into the liquid mixing tank, add purified water to make up to full v...

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Abstract

The invention discloses chlorhexidine gluconate gargle, which contains the following components in part by weight: 0.08 to 1.2 parts of chlorhexidine gluconate, 50 to 100 parts of propylene glycol, 50 to 100 parts of glycerol and 1 to 5 parts of polyoxyethylene 40 hydrogenated castor oil. The chlorhexidine gluconate gargle has a simple formula, a simplified process and stable quality.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a chlorhexidine gluconate gargle and a preparation method thereof. Background technique [0002] Oral disease is a kind of common frequently-occurring disease, and the incidence rate is high, and it is very harmful to human health, but it is often not taken seriously by people. According to a large number of literature reports at home and abroad, the main cause of oral diseases is the accumulation of a large number of pathogenic bacteria due to the accumulation of dental plaque in the gingival margin area, and the bacterial toxins and metabolites released by them cause periodontal and gingival damage. . Common oral diseases include gingivitis, oral mucositis, pharyngitis, etc. The incidence of oral diseases in the population is very high. Almost everyone has oral problems. About 60% of the population suffers from oral ulcers, bad breath, and pharyngitis to varying degrees. , w...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/43A61Q11/00
Inventor 王国华刘萍赵小萍杨勇傅启昌胡瀚涂吉敏
Owner 重庆健能医药开发有限公司
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