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New application of glutathione

A glutathione and lactam technology, applied in the directions of medical preparations containing active ingredients, tripeptide ingredients, resistance to vector-borne diseases, etc., to achieve the effect of improving sensitivity

Inactive Publication Date: 2017-06-23
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies on glutathione regulation of bacterial β-lactam antibiotic susceptibility have not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Glutathione increases penicillin susceptibility in Staphylococcus aureus, Streptococcus dysgalactiae, Escherichia coli and Streptococcus agalactiae:

[0021] 1. Experimental materials

[0022] (1) Strains: Staphylococcus aureus, Streptococcus dysgalactiae, Escherichia coli and Streptococcus agalactiae were all from the microbiological research group of Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences.

[0023] (2) Glutathione: It is a product of Sigma Company in the United States, and the product number is G4251. The weighed powder was dissolved in ultrapure water, filtered through a 0.2 micron filter and stored at 4°C.

[0024] (3) Hydrolyzed Casein Agar Medium: It is a product of Oxoid Company in the United Kingdom, and the product number is CM0337B. Dissolve the weighed powder in ultrapure water, autoclave at 121°C, and put it into a disposable 90mm Petri dish to make a hydrolyzed casein plate at room temperatu...

Embodiment 2

[0032] Glutathione increases susceptibility to ampicillin in Staphylococcus aureus, Streptococcus dysgalactiae, Escherichia coli and Streptococcus agalactiae:

[0033] 1. Experimental materials:

[0034] (1) Strains: Staphylococcus aureus, Streptococcus dysgalactiae, Escherichia coli and Streptococcus agalactiae were all from the microbiological research group of Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences.

[0035] (2) Glutathione: It is a product of Sigma Company in the United States, and the product number is G4251. The weighed powder was dissolved in ultrapure water, filtered through a 0.2 micron filter and stored at 4°C.

[0036] (3) Hydrolyzed Casein Agar Medium: It is a product of Oxoid Company in the United Kingdom, and the product number is CM0337B. Dissolve the weighed powder in ultrapure water, autoclave at 121°C, and put it into a disposable 90mm Petri dish to make a hydrolyzed casein plate at room tempe...

Embodiment 3

[0044] Glutathione increases the susceptibility of Staphylococcus aureus, Streptococcus dysgalactiae, Escherichia coli and Streptococcus agalactiae to cephalothin:

[0045] 1. Experimental materials:

[0046] (1) Strains: Staphylococcus aureus, Streptococcus dysgalactiae, Escherichia coli and Streptococcus agalactiae were all from the microbiological research group of Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences.

[0047] (2) Glutathione: It is a product of Sigma Company in the United States, and the product number is G4251. The weighed powder was dissolved in ultrapure water, filtered through a 0.2 micron filter and stored at 4°C.

[0048] (3) Hydrolyzed Casein Agar Medium: It is a product of Oxoid Company in the United Kingdom, and the product number is CM0337B. Dissolve the weighed powder in ultrapure water, autoclave at 121°C, and put it into a disposable 90mm Petri dish to make a hydrolyzed casein plate at room ...

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PUM

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Abstract

The invention discloses new application of glutathione, particularly application of glutathione respectively in preparation of beta-lactam-antibiotic-containing antibacterial or bactericidal drugs, preparation of antibacterial or bactericidal drugs capable of enhancing pathogenic bacteria removal capacity of beta-lactam antibiotics, and preparation of antibacterial or bactericidal drugs capable of lowering drug resistance of bacteria to beta-lactam antibiotics. The glutathione can obviously enhance the sensitivity of bacteria to beta-lactam antibiotics; and the combination of the glutathione and beta-lactam antibiotics has better antibacterial effects than the single use of the beta-lactam antibiotics under the condition of the same dose.

Description

technical field [0001] The invention relates to the field of antibacterial and bactericidal technology of antibiotics, in particular to the new application of glutathione. Background technique [0002] The discovery and application of antibiotics is a great revolution for human beings. Since then, human beings have a great weapon to fight against death, because the number one killer of human death is bacterial infection. However, in real life, due to the abuse and indiscriminate use of such antibiotics, drug-resistant strains have increased year by year, greatly reducing the efficacy of antibiotics. Bacteria resistant to β-lactam antibiotics are particularly prevalent because they are commonly used to cure bacterial diseases. Drug resistance is one of the most pressing public health problems worldwide. In September 2014, the United States announced a five-year national strategy to deal with antimicrobial resistance. In China, more than 80,000 people die from drug-resistan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/06A61P31/04A61K31/43A61K31/546
CPCA61K31/43A61K31/546A61K38/06A61K2300/00Y02A50/30
Inventor 杨峰李宏胜王旭荣罗金印李新圃
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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