The invention discloses a preparation method of a
piracetam freeze-dried
powder injection for injection. The preparation method comprises the following steps: 1, adding
piracetam into injection water to dissolve, adding 0.05%
active carbon to stir for 30 minutes at the
room temperature and filter, subsequently filtering the injection water into a filtrate A through a
filtration membrane with micro
pore diameter being 0.22 micron; 2, detecting PH value of the filtrate A in the step 1, carrying out
freeze drying on the filtrate A with the PH value meeting the injection requirements in a freeze dryer, namely putting a tube-type
bottle filled with the filtrate A on a plate layer of the freeze dryer to carry out heat preservation for 6-7 hours at the temperature being 45 DEG C below zero; opening a
vacuum pump, increasing the temperature of the plate layer to 0 DEG C and carrying out heat preservation for 30 hours when a vacuum degree is less than 10 Pa, increasing the temperature of the plate layer to 35 DEG C and carrying out heat preservation for 30 hours when the temperature in the tube-type
bottle is close to the temperature of the plate layer, ending freeze-
drying to prepare the freeze-dried
powder B when the temperature in the tube-type
bottle reaches 35 DEG C; (3) crushing the freeze-dried
powder B in the step (2) in the environment with the
humidity being less than 50%, sieving powder through a 30-mesh
sieve after crushing, and carrying out aseptic packaging, bundling cover and packaging.