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External preparation containing clindamycin phosphate

A technology for clindamycin phosphate and external preparations, applied in the field of pharmaceutical preparations, can solve problems such as easy hydrolysis and poor stability, and achieve the effects of good product stability and simple preparation process

Active Publication Date: 2014-07-02
GUANGZHOU DAGUANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In order to solve the problem of poor stability caused by the easy hydrolysis of the clindamycin phosphate structure, the inventor improved the prescription and process of the clindamycin phosphate preparation through a large number of experiments and unremitting exploration, and found that the drug was dissolved in In a certain amount of isopropyl myristate, the stability of the drug is significantly improved, thereby providing a clindamycin phosphate external preparation with higher stability

Method used

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  • External preparation containing clindamycin phosphate
  • External preparation containing clindamycin phosphate
  • External preparation containing clindamycin phosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028]

[0029] Preparation Process:

[0030] (1) Dissolve the clindamycin phosphate of the prescribed amount in the isopropyl myristate of the prescribed amount, and fill the solution in the container as component A;

[0031] (2) Prescription amount Carbomer 934, Tween 80 and methylparaben were dissolved in the prescription amount of water, and the solution was filled into a container as component B.

[0032] Before use, add component A to component B and stir evenly to obtain clindamycin phosphate gel.

Embodiment 2

[0034]

[0035] Preparation Process:

[0036] (1) Dissolve the clindamycin phosphate of the prescribed amount in the isopropyl myristate of the prescribed amount, and fill the solution in the container as component A;

[0037] (2) Prescription amount Carbomer 934, Tween 80 and methylparaben were dissolved in the prescription amount of water, and the solution was filled into a container as component B.

[0038] Before use, add component A to component B and stir evenly to obtain clindamycin phosphate gel.

Embodiment 3

[0040]

[0041] Preparation Process:

[0042] (1) Dissolve the clindamycin phosphate of the prescribed amount in the isopropyl myristate of the prescribed amount, and fill the solution in the container as component A;

[0043] (2) Prescription amount Carbomer 934, Tween 80 and methylparaben were dissolved in the prescription amount of water, and the solution was filled into a container as component B.

[0044] Before use, add component A to component B and stir evenly to obtain clindamycin phosphate gel.

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Abstract

The invention discloses an external preparation containing clindamycin phosphate. The external preparation comprises a component A and a component B, wherein the component A is isopropyl myristate liquor of clindamycin phosphate; the component B is aqueous liquor of a water-based gel matrix, an emulsifier and a preservative. The external preparation disclosed by the invention is simple in preparation process, free of a special storage condition, good in product stability and easy for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to an external preparation containing clindamycin phosphate, in particular to a clindamycin phosphate gel. Background technique [0002] The occurrence of acne is mainly closely related to factors such as excessive sebum secretion, pilosebaceous gland duct blockage, bacterial infection and inflammatory response. After entering puberty, the level of androgen in the human body, especially testosterone, increases rapidly, which promotes the development of sebaceous glands and produces a large amount of sebum. At the same time, abnormal keratinization of the pilosebaceous duct causes duct blockage, sebum discharge obstruction, and the formation of keratin plugs, that is, micropowder thorns. A variety of microorganisms in hair follicles, especially Propionibacterium acnes, multiply in large numbers. The lipase produced by Propionibacterium acnes decompo...

Claims

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Application Information

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IPC IPC(8): A61K47/14A61K9/06A61K31/7105A61P17/10
Inventor 白玲强
Owner GUANGZHOU DAGUANG PHARMA
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