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Bacterial cellulose-polylactic acid composite film and its preparation method, drug-carrying gauze based on composite film and its preparation method

A technology of bacterial cellulose and polylactic acid film, applied in biochemical equipment and methods, methods based on microorganisms, coatings, etc., can solve the problems of increasing patient pain, unfavorable post-injury healing, easy adhesion of wounds, etc., and achieve good tissue Compatibility, good product stability, and good skin compatibility

Pending Publication Date: 2017-09-19
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is easy to stick to the wound during use, which is not conducive to post-injury healing. In severe cases, it will cause focal infection and increase the pain of the patient when changing the dressing.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] A kind of medical gauze based on bacterial cellulose-polylactic acid composite film and preparation method thereof, comprises the following steps:

[0052] (1) Prepare polylactic acid film (Polylactic acid film, PLA film) by electrospinning method: prepare a mixed solvent (2:1, v / v) of chloroform and ethanol to dissolve PLA to obtain a PLA solution with a mass concentration of 30%; Inject 4.5mL PLA solution into a glass needle syringe; cut Φ5cm tinfoil paper, clamp it on the receiving end to form a receiver and connect one end of the wire to the receiving end; turn on the electrospinning machine, adjust the receiving distance to 10cm, and the spinning temperature to 40°C; install Connect the syringe to the voltage lead, open the voltage control area to apply voltage to the receiving end and the tip of the syringe; adjust the advancing speed to 0.1mm / s, start spinning, and form a PLA film on the receiver; after the film is dry, gently remove the film with tweezers Peel i...

Embodiment 2

[0056] A kind of medical gauze based on bacterial cellulose-polylactic acid composite film and preparation method thereof, comprises the following steps:

[0057] (1) Prepare polylactic acid film (Polylactic acid film, PLA film) by electrospinning method: prepare a mixed solvent (3:1, v / v) of chloroform and ethanol to dissolve PLA to obtain a PLA solution with a mass concentration of 35%; Inject 5.5mL PLA solution into a glass needle syringe; cut Φ7cm tinfoil paper, clamp it on the receiving end to form a receiver and connect one end of the wire to the receiving end; turn on the electrospinning machine, adjust the receiving distance to 15cm, and the spinning temperature to 50°C; install Connect the syringe to the voltage lead, open the voltage control area to apply voltage to the receiving end and the tip of the syringe; adjust the advancing speed to 0.2mm / s, start spinning, and form a PLA film on the receiver; after the film is dry, gently remove the film with tweezers Peel i...

Embodiment 3

[0061] A kind of medical gauze based on bacterial cellulose-polylactic acid composite film and preparation method thereof, comprises the following steps:

[0062] (1) Prepare polylactic acid film (Polylactic acid film, PLA film) by electrospinning method: prepare a mixed solvent (4:1, v / v) of chloroform and ethanol to dissolve PLA, and obtain a PLA solution with a mass concentration of 40%; Inject 6.5mL PLA solution into a glass needle syringe; cut Φ10cm tinfoil paper, clamp it on the receiving end to form a receiver and connect one end of the wire to the receiving end; turn on the electrospinning machine, adjust the receiving distance to 20cm, and the spinning temperature to 60°C; install Connect the syringe to the voltage lead, open the voltage control area to apply voltage to the receiving end and the tip of the syringe; adjust the advancing speed to 0.3mm / s, start spinning, and form a PLA film on the receiver; after the film is dry, gently remove the film with tweezers Pee...

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PUM

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Abstract

The invention provides a bacterial cellulose-polylactic acid composite film and its preparation method. The preparation method includes steps of (1), preparing a polylactic acid film by a static spinning method; (2), preparing a bacterial cellulose-polylactic acid composite film by an in-situ composite method. The bacterial cellulose-polylactic acid composite film avoids use of toxic chemical crosslinking agent in preparation process, and has high compounding efficiency and good product stability. The invention further provides a drug-carrying gauze based the bacterial cellulose-polylactic acid composite film and its preparation method; the preparation method includes steps of A), preparing the bacterial cellulose-polylactic acid composite film; preparing a drug solution; B), soaking the bacterial cellulose-polylactic acid composite film in the drug solution, and performing oscillation absorption under a vacuum condition; C), taking out the bacterial cellulose-polylactic acid composite film. The drug-carrying gauze has good drug-carrying performance and can be degraded in a body.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a bacterial cellulose-polylactic acid composite film, a drug-loaded gauze based on the bacterial cellulose-polylactic acid composite film and a preparation method. Background technique [0002] Bacterial cellulose (BC) is a polysaccharide natural polymer synthesized by bacteria. It is a new type of biological material that has been widely studied at present. Its nano-network structure can prevent the invasion of microorganisms, and its porous structure makes it With high water holding capacity, it can absorb wound exudate, keep the wound dry, avoid wound infection, promote cell regeneration, good mechanical properties make it have better shape retention, and can be designed according to the application. At the same time, the cultivation process is simple, degradable, environmentally friendly, and can realize large-scale practical application of the product. Polylactic acid (P...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08J7/04C08L67/04C12P19/04C12R1/02
CPCC12P19/04C08J5/18C08L67/04C08J2301/02C08J2367/04C08J2467/04C08J7/0427Y02W90/10
Inventor 张雯余婷婷彭晓雪沈文刘艺秀李亚蕊
Owner SHAANXI UNIV OF SCI & TECH
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