The invention relates to
imiquimod micro
emulsion gels for local
skin, at least comprising the following ingredients by
mass percent: 0.1-2.5 percent of
imiquimod, 1-24 percent of
solvent, 1-16 percent of surface
active agent, 1-12 percent of cosurfactant, 1-20 percent of gelatinizing agent and the remaining water; wherein the
imiquimod is 1-isobutyl-1H-
imidazole(4,5-C)
quinoline-4-amine; the preparation method comprises the following steps: the imiquimod is dissolved in the
solvent, the surface
active agent and the cosurfactant are added in the
solvent dissolved with the imiquimod, and the mixture is dispersed uniformly; water with [roper amount is added in the mixture to form micro
emulsion; the gelatinizing agent is swelled by water, so as to prepare the solution with a certain concentration, the gelatinizing agent solution is dropped in the imiquimod micro
emulsion dropwise, the stirring is carried out while the gelatinizing agent solution is dropped, the pH value is adjusted by adding
triethanolamine, so as to prepare the imiquimod micro emulsion gels; the invention has the advantages that: the thorough
dispersity of the micro emulsion to medicines, adhesiveness of gels to the
skin and deformation flowability thereof under external force are concentrated, so as to lead the
medicine to be applied to the affected part and cause the
medicine to pass into internal body and reach target spot through the
skin; the
medicine effect can act on continuously.