59 results about "Valnemulin Hydrochloride" patented technology

The invention relates to a crystalline valnemulin hydrochloride product and a crystallization preparation method thereof. The crystalline valnemulin hydrochloride product is defined by characteristic peaks of an X-ray powder diffraction spectrum in 2theta and DSC. The crystallization preparation method comprises the following steps: under the stirring action, at the temperature of 40-60 DEG C, dissolving an amorphous valnemulin hydrochloride raw material in some organic solvent, and stirring for 1 hour to be completely dissolved, wherein the final solution concentration is 0.5-1 g / mL; at the temperature of 40-60 DEG C, stirring and adding an ultrasonic unit into the solution to be subjected to ultrasonic treatment for 1-2 hours; then reducing the solution temperature to the final temperature of 5-15 DEG C at some cooling rate; continuously stirring at the final temperature, growing the grain for 1-2 hours, and washing, filtering and drying crystal mush to obtain the crystalline valnemulin hydrochloride product. The crystalline valnemulin hydrochloride product is relatively white in color, uniform in granularity, good in flowability and stability, low in hygroscopicity, and high in bulk density, and the once through yield during the crystallization process is higher than 90%.

The invention relates to valnemulin hydrochloride microspheres and preparation method thereof. The valnemulin hydrochloride microspheres are composed of a water phase, an oil phase and a crosslinking agent, wherein a volume ration of the water phase to the oil phase is 1:6-12. The water phase is composed of gelatin, valnemulin hydrochloride, polyvinylpyrrolidone and purified water and the oil phase is composed of an emulsifier and liquid paraffin. The preparation method includes following steps: preparing the water phase and the oil phase, adding the water phase dropwisely to the oil phase, adding the crosslinking agent, washing off the liquid paraffin on surfaces of the microspheres through petroleum ether and performing a vacuum-drying process to obtain the valnemulin hydrochloride microspheres.