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Uses of valnemulin hydrogen tartrate in veterinary drugs

A technology of warnimulin and tartaric acid, which is applied in the direction of antibacterial drugs and active ingredients of esters, can solve the problems of increased cost and no warnimulin tartrate, etc., and achieves easy storage, small residual amount and good therapeutic effect Effect

Inactive Publication Date: 2012-12-12
HUBEI LONGXIANG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although in the prior art, warnemulin hydrochloride is also treated by coating, which can increase the stability of the drug, but it increases the cost of production and processing.
[0004] At present, warnemulin tartrate is mainly used as a reference substance or standard substance for drug detection. There are no reports on other applications of warnemulin tartrate

Method used

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  • Uses of valnemulin hydrogen tartrate in veterinary drugs
  • Uses of valnemulin hydrogen tartrate in veterinary drugs
  • Uses of valnemulin hydrogen tartrate in veterinary drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 5

[0031] Embodiment 5 is the pharmacokinetic test of warnimulin tartrate.

[0032] In this study, high performance liquid chromatography was used to study the pharmacokinetic characteristics of a single dose of warnemulin tartrate (12mg / kg body weight) in pigs through oral and intravenous injection.

[0033] The plasma drug extraction method uses acetonitrile as the plasma protein precipitant and extraction agent, then adds anhydrous sodium sulfate to mix and centrifuge, then takes the supernatant and blows it dry, and the residue is ultrasonically dissolved in the mobile phase for HPLC detection. With tiamulin fumarate as the internal standard, the concentration range of 0.05μg / ml to 5μg / ml of warnimulin tartrate, the chromatographic peak area and concentration showed a good linear relationship, and the correlation coefficient reached more than 0.996. The limit of quantification of Lin in plasma is 0.05μg / ml.

[0034] Compartment model analysis showed that the data in the oral...

Embodiment 6

[0038] Embodiment 6 is the residual elimination test of warnemulin tartrate premix.

[0039] In this experiment, the elimination rule of warnemulin tartrate residues in pigs was studied. The samples were quantified by internal standard method, and pre-treated by liquid-liquid extraction, nitrogen drying, concentration and other steps. Liquid chromatography (RP-HPLC) determination. In the study of drug residues, pigs were continuously fed with a dose of 240 g of warnemulin tartrate per ton of feed mixed with warnemulin tartrate premix for 21 days. , 18, 24, 36h collected plasma, muscle, fat, liver and kidney samples for analysis and determination.

[0040] Give pigs 240g of warnemulin tartrate per ton of feed, and continuously feed mixed warnemulin tartrate premix for 21 days. The coefficient and elimination half-life are shown in Table-3. The results show that the drug concentration and elimination rate are different in different tissues. The concentration in the liver is the ...

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Abstract

The present invention provides uses of valnemulin hydrogen tartrate in veterinary drugs, and mainly relates to uses of the valnemulin hydrogen tartrate in preparations of drugs for treatments and preventions of veterinary diseases related to swine mycoplasma infection and bacterial infection. Compared to the prior art, the following characteristics in the present invention are provided: valnemulin hydrogen tartrate is made into a premix or a granule or powder, a mixing feeding way is adopted to achieve prevention and treatment of swine mycoplasma infection and bacterial infection, an anti-mycoplasma effect of the drug of the present invention is better than anti-mycoplasma effects of other similar products, and no drug resistance is generated. According to the present invention, the uses of the valnemulin hydrogen tartrate in veterinary diseases in the present invention are not presented in the prior art; compared with valnemulin hydrochloride, preparations prepared by the valnemulin hydrogen tartrate provide better effects for treatments of veterinary diseases, and especially for swine diseases; hygroscopicity of the valnemulin hydrogen tartrate is low, and is easily stored for a long time, wherein effects of the drug can not be affected; and palatability of the preparations prepared by the valnemulin hydrogen tartrate is stronger than palatability of valnemulin hydrochloride preparations in the prior art.

Description

technical field [0001] The invention relates to a use of warnemulin tartrate, in particular to the use of warnemulin tartrate in veterinary medicine. Background technique [0002] With the development of the livestock breeding industry, animal diseases caused by mycoplasma infection or bacterial infection caused by the increase of stocking density are becoming more and more rampant. As a new generation of pleuromutilin, warnemulin hydrochloride was born out of time. [0003] Valnemulin Hydrochloride was first synthesized by Sandoz Company in 1984 using Pleuromutilin as a raw material. It belongs to the same class of drugs as tiamulin and is an antibiotic for animals. In 1999, it was approved by the European Community for the prevention and treatment of swine dysentery caused by Brachyspira hyodysenteriae infection and swine enzootic pneumonia caused by Mycoplasma pneumoniae infection. Subsequently, Norvatis of Switzerland made it into a premix, which was launched in Europe...

Claims

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Application Information

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IPC IPC(8): A61K31/22A61P31/04
Inventor 王铭宏吴东林
Owner HUBEI LONGXIANG PHARMA TECH CO LTD
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