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Valnemulin hydrochloride solution and preparation method of same

A technology of warnemulin hydrochloride and solution, which is applied in the direction of pharmaceutical formulations, antibacterial drugs, active ingredients of esters, etc., can solve the problems of low dissolution rate and low bioavailability, and achieve high bioavailability and drug administration convenient effect

Inactive Publication Date: 2012-04-18
上海恒丰强生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] An object of the present invention is to provide a solution of warnemulin hydrochloride, to overcome the defects of low dissolution rate and low bioavailability of the existing warnemulin hydrochloride premix

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0020] The warnemulin hydrochloride solution is calculated by weight percentage, and is mainly composed of warnemulin hydrochloride as a main ingredient, and is prepared with an appropriate amount of polyethylene glycol.

[0021] formula:

[0022] Warnemulin Hydrochloride 5%

[0023] Polyethylene glycol 95%.

[0024] production method

[0025] (1) in the preparation in advance, the warnemulin hydrochloride weighed according to the requirements is dissolved with an appropriate amount of polyethylene glycol for subsequent use;

[0026] (2) Add polyethylene glycol to the full amount, continue to stir to make it evenly mixed, stir the liquid medicine evenly under the condition of stirring, and then test it;

[0027] (3) After passing the inspection, it is filled and sealed under the condition of stirring, and then labeled, packaged, randomly inspected, and put into storage.

Embodiment 2

[0029] The said warnemulin hydrochloride solution of the present embodiment, by weight percentage, said warnemulin hydrochloride is 5%, polyethylene glycol is 95%. Its preparation method is with embodiment 1.

[0030] The warnemulin hydrochloride solution of the present invention adopts the method of dissolving the warnemulin hydrochloride in an organic solvent, so that the warnemulin hydrochloride exists in the form of a solution and is administered in the form of an oral liquid. Warnemulin hydrochloride is a kind of highly fat-soluble, extremely difficult to dissolve in water and general organic solvents, the dissolution rate of the premix is ​​low, and the bioavailability is not high. After it is developed into a solvent by pharmaceutical methods, it is convenient for administration. High bioavailability.

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Abstract

The invention discloses a valnemulin hydrochloride solution. The valnemulin hydrochloride solution consists of the following raw materials in percentage by weight: 5% of valnemulin hydrochloride and 95% of polyglycol. The invention also discloses a preparation method of the valnemulin hydrochloride solution. In the invention, an organic solvent is adopted to dissolve the valnemulin hydrochloride, so that the valnemulin hydrochloride exists in a manner of solution, and is administered in the form of oral liquid. The valnemulin hydrochloride has the characteristics of high liposolubility, difficulty in dissolving in water and general organic solvents, low premix dissolution rate and low bioavailability, but solvent of the valnemulin hydrochloride developed by a pharmaceutical method is convenient to administer, and has high bioavailability.

Description

technical field [0001] The invention belongs to the field of veterinary drug antibiotics, and in particular relates to a solution of warnemulin hydrochloride and a preparation method thereof. Background technique [0002] Valnemulin hydrochloride (also known as fluvonimulin, Valnemulin), the chemical name is ((2-((R)-2-amino-3-methylbutyrylamino)-1,1-dimethylethyl group) mercapto) acetic acid, (3aS, 4R, 5S, 6S, 8R, 9R, 9aR, 10R)-octahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-vinyl - 3a,9-Propane-3aH-cyclopentacyclooctene-1(4H)-one-8-ester. Vernimulin is a new generation of pleuromutilin semi-synthetic antibiotics. It belongs to the diterpene class and belongs to the same class of drugs as tiamulin. It is a special antibiotic for animals. It is mainly used to prevent mycoplasma disease and Gram-positive bacterial infection in pigs, cattle, sheep and poultry. In 1999, it was approved by the European Community for the prevention and treatment of swine dysentery caused by Bra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/22A61K47/34A61P31/04
Inventor 龙谭廖洪
Owner 上海恒丰强生物技术有限公司
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