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A kind of warnemulin hydrochloride premix for animals and preparation method thereof

A technology of vornimulin hydrochloride and premix, which is applied in the directions of ester active ingredients and antibacterial drugs, can solve the problems of affecting animal feeding, increasing the number of administrations, temperature sensitivity, etc., and achieves no irritating odor, The effect of increasing molecular force and high fluidity

Active Publication Date: 2011-12-07
武汉回盛生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, warnemulin hydrochloride is easy to hydrolyze, is sensitive to temperature, and has poor stability
At present, warnemulin hydrochloride is mainly administered orally, but the raw material of warnemulin hydrochloride has a strong odor, strong irritation, and is easy to disperse, making it poor in palatability and affecting animal feed intake. It is necessary to increase the number of administrations, which is not conducive to achieve high therapeutic effect

Method used

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  • A kind of warnemulin hydrochloride premix for animals and preparation method thereof
  • A kind of warnemulin hydrochloride premix for animals and preparation method thereof
  • A kind of warnemulin hydrochloride premix for animals and preparation method thereof

Examples

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Effect test

Embodiment 1

[0032] A kind of warnemulin hydrochloride premix for animals, its preparation method is as follows:

[0033] (1) Stir and mix 5g of warnemulin hydrochloride crude drug and 5g of β-cyclodextrin for 30 minutes to make a drug-coated carrier mixture;

[0034] (2) Add 0.2g sorbitol and 0.1ml absolute ethanol to the above mixture, continue stirring and mixing to obtain a semi-inclusion drug;

[0035] (3) Slowly add 0.05ml of polyethylene glycol 200 dropwise to the half-included drug in step (2) to increase the encapsulation efficiency, stir for 1.5h at a speed of 800r / min after dropping, and then vacuum dry to The absolute ethanol was volatilized completely, and the powdered warnemulin hydrochloride inclusion complex was obtained, and the encapsulation efficiency and drug loading were measured;

[0036] (4) According to the drug loading, add starch and place it in a stirring mixer, and stir for 15 minutes to dilute the warnemulin hydrochloride clathrate obtained above to a 10% warn...

Embodiment 2

[0039] A kind of warnemulin hydrochloride premix for animals, its preparation method is as follows:

[0040] (1) Stir and mix 5g of warnemulin hydrochloride crude drug and 10g carrier complex (a mixture of β-cyclodextrin and polyethylene glycol 6000 in a weight ratio of 2:1) for 30 minutes to make a drug- coating carrier mixture;

[0041] (2) Add 0.45g sorbitol and 0.3ml absolute ethanol to the above mixture, continue stirring and mixing to obtain a semi-inclusion drug;

[0042] (3) Slowly add 0.075ml of polyethylene glycol 200 dropwise to the semi-included drug in step (2), stir at a speed of 800r / min for 1.5h after dropping, then vacuum dry until the absolute ethanol volatilizes completely, Obtain the inclusion complex of warnemulin hydrochloride in powder form, and measure the encapsulation efficiency and drug loading;

[0043] (4) According to the drug loading, add starch and place it in a stirring mixer, and stir for 15 minutes to dilute the warnemulin hydrochloride cla...

Embodiment 3

[0046] A kind of warnemulin hydrochloride premix for animals, its preparation method is as follows:

[0047] (1) Stir and mix 5g of warnemulin hydrochloride crude drug and 15g carrier complex (a mixture of β-cyclodextrin and polyethylene glycol 6000 in a weight ratio of 3:1) for 30 minutes to make a drug- coating carrier mixture;

[0048] (2) Add 0.8g sorbitol and 0.5ml dehydrated ethanol to the above mixture, continue stirring and mixing to obtain a semi-inclusion drug;

[0049] (3) Slowly add 0.2ml of polyethylene glycol 200 dropwise to the half-included drug in step (2) to increase the encapsulation efficiency, stir at a speed of 800r / min for 1.5h after dropping, and then vacuum-dry to nothing. The water and ethanol were completely volatilized to obtain the powdered warnemulin hydrochloride inclusion compound, and the encapsulation efficiency and drug loading were measured;

[0050] (4) According to the drug loading, add starch and place it in a stirring mixer, and stir f...

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Abstract

The invention relates to the technical field of veterinary antibiotic preparations, and particularly discloses a veterinary valnemulin hydrochloride premix and a preparation method thereof. The premix comprises a valnemulin hydrochloride clathrate and a matrix diluent, wherein the coating carrier of the clathrate is any one of or a mixture of two of beta-cyclodextrin, hydroxypropyl beta-cyclodextrin, polyethylene glycol 4000, polyethylene glycol 6000, and ethyl cellulose; and the matrix diluent is any one of or a mixture of two or three of starch, maltodextrin, miropowder silica gel and talcum powder. Anhydrous ethanol and liquid state polyethylene glycol are added in the clathrate to promote the bonding of the clathrate, and wetting agent sorbitol is added to form a semi-solid state, so as to increase the molecular acting force between the entire medicine and a polymer carrier and increase the encapsulation rate of the clathrate. The prepared veterinary valnemulin hydrochloride premix has the advantages of stable properties, good uniformity, high fluidity, and no pungent odor.

Description

technical field [0001] The invention relates to the technical field of veterinary antibiotic preparations, in particular to a veterinary warnemulin hydrochloride premix and a preparation method thereof. Background technique [0002] Warnemulin hydrochloride is a new generation of pleuromutilin semi-synthetic antibiotics. It belongs to diterpenes and belongs to the same class of drugs as tiamulin. It is an antibiotic for animals and a recognized first choice for the treatment of mycoplasma in livestock drug. It is mainly used to prevent mycoplasma disease and Gram-positive bacterial infection in pigs, cattle, sheep and poultry. It is an effective method for preventing porcine enzootic pneumonia (or porcine asthma, porcine mycoplasma pneumonia), actinomyces pleuropneumonia, swine dysentery, porcine spirochete disease (colitis), porcine proliferative enteropathy (ileitis) and other diseases. A very sensitive new animal-specific antibiotic, it is the first veterinary drug prem...

Claims

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Application Information

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IPC IPC(8): A61K31/22A61P31/04
Inventor 张卫元操继跃陈翠兰刘国庆张永丹李荣肖飞
Owner 武汉回盛生物科技股份有限公司
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