41 results about "Chlortetracycline Hydrochloride" patented technology

A SERS detection method for aureomycin hydrochloride relates to the detection of tetracycline antibiotics. Au nanoparticle sol is prepared by reducing chloroauric acid with sodium citrate, and gold nanoparticles with uniform particle size are obtained by controlling the concentration of reactants, reaction time, reaction temperature and stirring speed; SERS substrate, control the pH of aureomycin hydrochloride solution, add a fluorescence quencher, and perform surface-increased Raman detection on aureomycin hydrochloride on the SERS substrate, as the concentration of aureomycin hydrochloride increases, The Raman peak of chlortetracycline hydrochloride at a specific wavelength is gradually enhanced, and the intensity of the Raman characteristic peak of chlortetracycline hydrochloride is proportional to the amount of chlortetracycline hydrochloride. Quantitative analysis detection. It has the advantages of low detection limit, high sensitivity, good detection reproducibility, fast detection speed, high recovery rate of sample addition, etc., and can meet the requirements of rapid analysis and detection.

The invention belongs to the technical field of chemical synthesis, and more specifically relates to a water soluble chlorotetracycline succinic acid monoester salt, and a preparation method thereof. The preparation method is used for modifying chlorotetracycline. The chlorotetracycline succinic acid monoester salt possesses a structure represented by formula I, wherein M is used for representing Na, K, meglumine, arginine, or lysine. According to the preparation method, grafting modification of chlorotetracycline with succinic anhydride is carried out so as to obtain the chlorotetracycline succinic acid monoester salt with water solubility better than that of chlorotetracycline, and broad-spectrum antibacterial property of the water soluble chlorotetracycline succinic acid monoester salt is the same as that of chlorotetracycline in animal bodies.

The invention provides a potassium-nitrogen co-doped carbon dot based on steamer peel and its preparation method and application. In the invention, the potassium-nitrogen co-doped carbon dots are prepared by one-step hydrothermal reaction by taking steamer peel and ethylenediamine as precursors and secondary water as a solvent. The method for preparing carbon quantum dots in the invention is simple, low in cost and easy to obtain raw materials. The potassium-nitrogen co-doped carbon dots were synthesized from discarded steamer peels, which can realize the rational utilization of biomass waste, which not only saves energy, but also is beneficial to environmental protection. The prepared carbon quantum dots have excellent optical properties, and different detection mechanisms based on fluorescence enhancement, fluorescence ratio and fluorescence quenching can realize the identification and selective detection of tetracycline antibiotics. The carbon quantum dot of the invention can be used to detect the contents of aureomycin hydrochloride, tetracycline and oxytetracycline in milk, honey, fish and pork.

The invention relates to a preparation method of hydrochloric acid aureomycin; the technical steps are listed below: firstly acidifying aureomycin broth; adjusting pH to 2-2.5; standing; continuously adjusting pH to 4-4.5; standing; adding water to reduce viscosity to 3000-4000cps pretreatment; carrying out membrane filtration, nanofiltration, crystallization, washing, salt forming, leaching and drying to obtain hydrochloric acid aureomycin powders. The method can improve extraction yield of the hydrochloric acid aureomycin, reduces production cycle and cost, and improves hydrochloric acid aureomycin output.

The invention discloses a method for recovering a chlortetracycline hydrochloride crystal mother liquor. The method includes the following steps: a. natural sedimentation of the chlortetracycline hydrochloride crystallization mother liquor at low temperature, and filtering; b. adjusting the pH of the filtrate with an alkaline solution, adding a filter aid, and filtering; c. dissolving the filter cake with an oxalic acid solution , add a purifying agent and filter; d. perform solvent extraction with multi-carbon alcohol or a mixed solution of multi-carbon alcohol and acetate, and cool the extract; e. use urea double salt, wash, crystallize, and dry. The method for recovering the chlortetracycline hydrochloride crystal mother liquor provided by the invention can make the recovered chlortetracycline hydrochloride content reach more than 80%, the titer unit can reach more than 900u / ml, and the recovery yield can reach more than 50%. The method of the invention effectively avoids the waste caused by discarding the chlortetracycline crystal mother liquor in the production process of chlortetracycline hydrochloride, can save 5% of the production cost, and simultaneously reduces the environmental pollution in the production process.

The invention belongs to the field of feed additives and in particular relates to a veterinary chlortetracycline premix and a preparation method thereof. The premix is prepared from the following raw materials in parts by weight: 20 to 30 parts of chlortetracycline hydrochloride, 30 to 40 parts of N-trimethyl chitosan, 20 to 40 parts of starch, 2 to 6 parts of polyvinylpyrrolidone K30, 1 to 3 parts of a chitosan-EDTA (Ethylene Diamine Tetraacetic Acid) complex and 10 to 18 parts of water, and further comprises 4 to 8 parts of a sweetener; the sweetener is one of sucrose, lactose, sorbitol and mannitol. The premix is prepared into grains by adopting a wet-process granulation process and the prepared premix grains are uniform and have high granulation rate and stable quality. Furthermore, the premix can be used for effectively reducing complex compounds formed by the chlortetracycline hydrochloride and metal ions in gastrointestinal tracts; the chlortetracycline hydrochloride can be incompletely released in gastric juice and the bioavailability of the chlortetracycline hydrochloride is improved. The preparation process of the premix provided by the invention is simple and industrial application is easy to realize.