128results about How to "Reduce chance of drug resistance" patented technology

The invention discloses a chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative as well as a preparation method and application thereof. The chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative is a compound with the general structural formula (I), wherein R1 is H, methyl or ethyl, and R2 is H or methyl. According to the chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative provided by the invention, fluoroquinolone, isoniazide and pyrazole aldehyde hydrazone are effectively combined to form a compound with a new structure; superposition and cooperation of activity are achieved; superposition of the three pharmacophores of fluoroquinolone, isoniazide and pyrazole aldehyde hydrazone is realized, the antituberculosis activity is improved, the toxic and side effects of fluoroquinolone and isoniazide to normal cells are decreased, and meanwhile, the probability that mycobacterium tuberculosis resists such drugs can be lowered; the chirality 7-(piperazine-substituted pyrazol aldehyde condensation isoniazide) fluoroquinolone carboxylic acid derivative can serve as an antituberculous active substance used for development of an antituberculous drug with a new structure.

The invention discloses a bactericidal composition containing tridemorph, which is a bactericidal composition containing A and B. A is imazalil or prochloraz, and B is tridemorph, wherein the weight part ratio of the active component A to the active component B is 32:1 to 1:32. The composition has obvious synergic effect, can prevent various diseases and ensures high safety to crops; and moreover, the composition has the advantages of rain resistance, drug effect durability and the like.

The invention discloses a bactericidal composition, which contains synergy effective quantity of metconazole and one of triadimefon, tebuconazole, hexaconazole, cyproconazole, triadimenol, bitertanol and diniconazole serving as a triazole bactericide, wherein the weight part ratio of the two active ingredients in the bactericidal composition is 80:1-1:80. The bactericidal composition at least contains one surfactant which is favorable for dispersion of the active ingredients in water during application. The bactericidal composition has protection, treatment and weeding activities, can be used for multiple crops such as wheat, rice, vegetables, fruit trees and the like, and can be used for preventing and controlling plant diseases caused by pathogenic bacteria of aseomycotina, basidiomycolina and deuteromycotina.

The invention discloses a bactericidal composition containing mandipropamid, which is a bactericidal composition containing A and B, wherein A is selected from any one of the followed dithiocarbamates bactericide: propineb, metiram and zineb; B is selected from the mandipropamid; and the weight part ratio of the active component A to the active component B is (1-100) : (1-50). The composition disclosed by the invention has remarkable synergistic effect, can be used for preventing various diseases, has good safety for plants, and has the advantages of rain drop erosion resistance, durable pesticide effect and the like.